Browse our phosphodiesterase 5A, cGMP-Specific Proteins (PDE5A)

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.

• phosphodiesterase 5A (PDE5A)
• phosphodiesterase 5A (Pde5a)
• phosphodiesterase 5A, cGMP-specific (Pde5a)
• phosphodiesterase 5A S homeolog (pde5a.S)
• phosphodiesterase 5A, cGMP-specific, b (pde5ab)
• Show all gene names
• phosphodiesterase 5A (pde5a)

• cgb-pde protein
• Cgbpde protein
• cn5a protein
• Cn5n protein
• pde5 protein
• Show all synonym aliases
• pde5a protein
• pde5a1 protein
• PDE5A2 protein

cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase , cGMP-specific 3',5'-cyclic phosphodiesterase , cGMP-specific phosphodiesterase PDE5A2 , cGMP-specific phosphodiesterase type 5A , phosphodiesterase isozyme 5 , CGB-PDE , cGMP-binding cGMP specific phosphodiesterase 5A2 , cGMP-binding cGMP-specific phosphodiesterase , phosphodiesterase type 5 , cGMP-binding/cGMP-specific phosphodiesterase , 3',5'-Cyclic GMP Phosphodiesterase , phosphodiesterase 5A, cGMP-specific , phosphodiesterase 5a, cGMP-specific , phosphodiesterase 5a , cGMP-specific 3',5'-cyclic phosphodiesterase-like , cyclic nucleotide phosphodiesterase 5a