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anti-Human USP20 Antibodies:
anti-Mouse (Murine) USP20 Antibodies:
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Human Polyclonal USP20 Primary Antibody for IHC (p), IHC - ABIN249927
Curcio-Morelli, Zavacki, Christofollete, Gereben, de Freitas, Harney, Li, Wu, Bianco: Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. in The Journal of clinical investigation 2003
USP20 is a positive regulator of beta-catenin in cancer cell migration, invasion and tumor growth in vivo. Mechanistically, USP20 deubiquitinates and stabilizes beta-catenin and is a potential biomarker for predicting chemoresistance in cancer.
our results demonstrate a role of the USP20 deubiquitinating enzyme in acting as a critical regulator of ULK1 and show a novel mechanism of the autophagy process in terms of ULK1 stability.
USP20 regulates actin cytoskeleton organization and cell migration in a manner dependent on ERK3 expression. The results identify USP20 as a bona fide regulator of ERK3 stability and physiological functions.
we investigated the inter-action between PKM2 and USP20. Our results suggest a new molecular pathway in cancer metabolism through the regulation of PKM2.
findings reveal a dynamic regulation of USP20 by site-specific phosphorylation as well as the interdependence of signal transduction and trafficking pathways in balancing adrenergic stimulation and maintaining cellular homeostasis
data establish a new function of USP20 in genome maintenance and DNA repair.
Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population.
Our results point to USP20 as a key negative regulator of HTLV-1 Tax-induced NF-kappaB signaling.
identification and description of VDU2 in human cells
von Hippel-Lindau protein-interacting deubiquitinating enzyme 2 (VDU2) deubiquitinates and stabilizes HIF-1alpha.
USPs 20 and 33 serve as novel regulators that dictate both post-endocytic sorting as well as the intensity and extent of beta(2)AR signalling from the cell surface.
These findings suggest a crucial role of USP20 in maintaining the stability of MITA and promoting innate antiviral signaling.
USP20 attenuates TNF- and IL-1beta-evoked atherogenic signaling in smooth muscle cells, by deubiquitinating RIPK1, among other signaling intermediates.
USP20 regulates beta1AR signaling in vitro and in vivo Additionally, beta1AR-induced USP20 phosphorylation may serve as a feed-forward mechanism to stabilize beta1AR expression and signaling during pathological insults to the myocardium.
that pro- and anti-inflammatory activities of beta-arrestin2 are determined by beta-arrestin2 ubiquitination and that changes in USP20 expression and/or activity can therefore regulate inflammatory responses
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein.
universal stress protein
, ubiquitin specific peptidase 20
, ubiquitin specific protease 20
, Deubiquitinating enzyme 20
, Ubiquitin thioesterase 20
, Ubiquitin-specific-processing protease 20
, ubiquitin carboxyl-terminal hydrolase 20
, ubiquitin thiolesterase 20
, deubiquitinating enzyme 20
, pVHL-interacting deubiquitinating enzyme 2
, ubiquitin thioesterase 20
, ubiquitin-specific-processing protease 20
, VHL-interacting deubiquitinating enzyme 2