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the present study was the first to identify 2 novel, potentially 'diseasecausing' TRERF1 somatic mutations in the endometriotic lesions in 2 out of 92 patients with ovarian endometriosis; therefore, TRERF1 mutations may be involved in the pathogenesis of ovarian endometriosis.
TReP-132 plays a role in regulating p450scc (show CYP11A1 Proteins) expression with steroidogenic factor-1 (show NR5A1 Proteins) and CBP/p300 (show CREBBP Proteins)
TReP-132 interacts with steroidogenic factor-1 (SF-1 (show NR5A1 Proteins)) through specific domains; and along with the interaction with CBP/p300 (show CREBBP Proteins) these factors are postulated to form a complex to regulate expression of the P450scc (show CYP11A1 Proteins) gene.
TReP-132 is a trans-acting factor of genes involved in adrenal glucocorticoid, C(19) steroid and estrogen production.
TReP-132 is a basal cell cycle regulatory protein (show RCC1 Proteins) interacting with Sp1 (show PSG1 Proteins) to activate the p21 (show CDKN1A Proteins) and p27 (show PAK2 Proteins) gene promoters.
identify TReP-132 as a coactivator of progesterone receptor (show PGR Proteins) mediating the growth-inhibitory and differentiation effects of progesterone on breast cancer cells
cloning and characterization; expression of both mTReP-132 and P450scc (show CYP11A1 Proteins) provides anatomical evidence that mTReP-132 may regulate this key steroidogenic enzyme within specific regions of the brain involved in behavioral and psychiatric disorders
This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1.
breast cancer anti-estrogen resistance 2
, transcriptional regulating protein 132
, transcriptional-regulating factor 1
, transcriptional-regulating protein 132
, zinc finger protein rapa
, zinc finger transcription factor TReP-132
, transcriptional regulating factor 1