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Data suggest that killer cell lectin-like receptors NKR (show TACR3 Proteins)-P1B:Clr-b (Klrb1 (show KLRB1 Proteins):Clec2d) interactions may provide a model for human hematopoietic cell transplants.
Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.
LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG Proteins) contributes to modulate immune responses
cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b is displayed at high levels on nearly all hematopoietic cells, in a pattern that is similar to that of class I MHC molecules.
Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells.
Limited divergence of the BALB/c Nkrp1-Ocil/Clr region helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells.
OCIL is a physiological negative regulator of bone.
PTHrp(1-34) regulates OCIL expression in vitro through cAMP/PKA, Ca(2 (show CA2 Proteins)+)/CaMK II (show CAMK2B Proteins), and MAPK (show MAPK1 Proteins) signaling pathways.
Identification of a novel family of genes, named Clr (show CALCR Proteins), encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.
Mouse Nkrp1d and Nkrp1f (show KLRB1F Proteins) bind specific C-type lectin-related (Clr (show CALCR Proteins)) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr (show CALCR Proteins) are intertwined in a genetically conserved NKC region.
Blocking LLT1-NKRP1A (show KLRB1 Proteins) interaction will make prostate cancer cells susceptible to killing by NK cells, suggesting a therapeutic option for treatment of prostate cancer.
these data suggest that LLT1-CD161 (show KLRB1 Proteins) interactions play a novel and important role in B cell maturation (show TNFRSF17 Proteins) within the Germinal center in humans.
In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage.
The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin (show MBL2 Proteins)-like proteins in the glycosylated form.
One polymorphism in LLT1 was found to be associated with our Crohn's Disease population (P<0.034).Our Ulcerative Colitis cohort was not associated with the variation in LLT1 (P=0.33)
LLT1 and CD161 (show KLRB1 Proteins) have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG Proteins) contributes to modulate immune responses
Molecular basis for LLT1 protein recognition by human CD161 (show KLRB1 Proteins) protein (NKRP1A/KLRB1 (show KLRB1 Proteins)).
Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface.
LLT1 used Src (show SRC Proteins)-PTK, p38 (show CRK Proteins) and ERK (show EPHB2 Proteins) signalling pathways, but not PKC (show PRRT2 Proteins), PI3K (show PIK3CA Proteins) or calcineurin pathways, to increase production of IFN-gamma (show IFNG Proteins) by human natural killer cells.
LLT1 induces Interferon (show IFNA Proteins) Type II production by natural killer cells.
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
osteoclast inhibitory lectin
, c-type lectin-like receptor
, C-type lectin domain family 2, member D
, C-type lectin domain family 2 member D
, C-type lectin-domain family 2 member D
, C-type lectin-related protein B
, lectin-like transmembrane protein
, C-type lectin related f
, C-type lectin superfamily 2, member D
, lectin-like NK cell receptor
, lectin-like transcript 1
, C-type lectin domain family 2 member D5