CLEC2D Protein (Fc Tag)

Catalog No. ABIN7321164

Product Details

Target: CLEC2D (C-Type Lectin Domain Family 2, Member D (CLEC2D))

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purification tag / Conjugate: This CLEC2D protein is labelled with Fc Tag.

Purpose: Recombinant Rat CLEC2D/OCIL Protein (Fc Tag)

Sequence: Lys98-Leu233

Characteristics: A DNA sequence encoding the rat CLEC2D (NP_569086.1) (Lys98-Leu233) was expressed with Fc region of human IgG1 at the N-terminus.

Purity: (76.7+14.8) % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CLEC2D (C-Type Lectin Domain Family 2, Member D (CLEC2D))

Alternative Name: CLEC2D/OCIL (CLEC2D Products)

Synonyms: CLAX Protein, LLT1 Protein, OCIL Protein, Clr-b Protein, Clrb Protein, Ocil Protein, Clec2d5 Protein, CLEC2D Protein, C-type lectin domain family 2 member D Protein, C-type lectin domain family 2, member d Protein, C-type lectin domain family 2, member D Protein, CLEC2D Protein, Clec2d Protein

Background:

Background: Lectin-like transcript 1 (LLT1) encoded by CLEC2D gene is a C-type lectin-like molecule interacting with human CD161 (NKR-P1A) receptor expressed by natural killer cells and subsets of T cells. CLEC2D transcripts were detected primarily in hematopoietic cell lines and were found to be co-induced by the same activation signals. Although very low amounts of putative soluble CLEC2D protein isoforms could be produced by transfectants, CLEC2D isoforms 2 and 4 were efficiently expressed. CLEC2D uses gene splicing to generate protein isoforms that are structurally distinct and that have different biological activities. Prostate cancer is the most common type of cancer diagnosed and the second leading cause of cancer-related death in American men. Natural Killer (NK) cells are the first line of defense against cancer and infections. NK cell function is regulated by a delicate balance between signals received through activating and inhibitory receptors. Previously, we identified Lectin-like transcript-1 (LLT1/OCIL/CLEC2D) as a counter-receptor for the NK cell inhibitory receptor NKRP1A (CD161). Interaction of LLT1 expressed on target cells with NKRP1A inhibits NK cell activation.

Synonym: CLEC2D

Molecular Weight: 44 kDa

NCBI Accession: NP_569086

Pathways: Regulation of Leukocyte Mediated Immunity