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These data,demonstrating the downregulation of the mRNA and protein expression levels of GIMAP5 and GIMAP6 (show GIMAP6 Antibodies) in the tumor tissues and blood of patients with HCC (show FAM126A Antibodies), suggested the involvement of GIMAP5 and GIMAP6 (show GIMAP6 Antibodies) in the pathogenesis of HCC (show FAM126A Antibodies), and indicate their possible use as diagnostic markers for HCC (show FAM126A Antibodies).
gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut (show GUSB Antibodies) [review]
Data indicate that overexpression of GTPase (show RACGAP1 Antibodies) of the immune-associated nucleotide (show GIMAP8 Antibodies)-binding protein (show COASY Antibodies) 5 (show CAPS Antibodies) (GIMAP5) in HEK (show EPHA3 Antibodies) (human embryonic kidney)-293 cells resulted in increased Ca2 (show CA2 Antibodies)+ accumulation within the mitochondria.
Notch (show NOTCH1 Antibodies) signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5.
These data establish Gimap5 as a key regulator of hematopoietic integrity and lymphocyte homeostasis
A significant increase in systemic lupus erythematosus risk associated with the most common GIMAP5 haplotype was found (odds ratio 1.26, 95% CI 1.02 to 1.54, p = 0.0033).
Resutls show that Gimap5 is located in the endoplasmic reticulum, and the endogenous Gimap5 mRNA is up-regulated in activated T-cells.
These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same single nucleotide polymorphism in another autoimmune disease.
Data show that IAN5 polymorphisms are associated with susceptibility to Systemic lupus erythematosus and the development of clinical disease manifestations in a strictly Korean population.
functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells.
gimap5 (show GIMAP3 Antibodies) has a role in maintaining peripheral tolerance and T cell homeostasis in the gut (show GUSB Antibodies) [review]
The defects in T-cell cellularity were more severe in mice lacking both Gimap3 (show GIMAP3 Antibodies) and Gimap5 (show GIMAP3 Antibodies).
a novel link between Gimap5 (show GIMAP3 Antibodies) and Foxo (show FOXO3 Antibodies) expression and provide evidence for a regulatory mechanism that controls Foxo (show FOXO3 Antibodies) protein expression and may help to maintain immunological tolerance.
Gimap5 (show GIMAP3 Antibodies) is an important stabilizer of mouse hematopoietic progenitor cell survival.
mouse gimap5 (show GIMAP3 Antibodies) is necessary for the survival of peripheral T cells, NK/NKT (show CTSL1 Antibodies)-cell development, and the maintenance of normal liver function
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene.
GTPase, IMAP family member 5
, GTPase IMAP family member 5
, immune associated nucleotide 4 like 1
, immunity associated protein 3
, immunity-associated nucleotide 5 protein
, inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5
, immunity-associated nucleotide 4-like 1 protein
, immunity-associated protein 3
, immunity-associated nucleotide 4 protein