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anti-Human HLA-B Antibodies:
anti-Mouse (Murine) HLA-B Antibodies:
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Human Polyclonal HLA-B Primary Antibody for WB - ABIN1944779
Little, Parham: The HLA-Bw75 subtype of B15: molecular characterization and comparison with crossreacting antigens. in Tissue antigens 1992
Show all 5 Pubmed References
Human Polyclonal HLA-B Primary Antibody for WB - ABIN516466
Lorente, García, López: Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells. in The Journal of biological chemistry 2011
Show all 3 Pubmed References
rs12524487 in HLA-B/MICA was a genetic risk factor for Takayasu arteritis in a Chinese Han population and rs9366782 in this region was associated with ischemic brain disease in TA but not TA susceptibility.
this study demonstrates an association between HLA-B alleles and carbamazepine-induced maculopapular exanthema and severe cutaneous reactions in Thai patients
Significant association between the HLA-B*15:02 genotype and the B-75(15) serotype and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Javanese and Sundanese populations.
this study shows that HLA-B genetic variance is associated with HIV-1 viral load in seroconverters from Zambia and Rwanda
This analysis showed that HLA-B*58:01 genetic testing before allopurinol initiation is unlikely to be a cost-effective intervention in Malaysia.
Association of HLA-B*15:02 with phenytoin-induced SJS (show HSPG2 Antibodies)/TEN is rare in the population studied.
The SNPs rs116488202 and rs4349859 may have a place in the identification of HLA-B27 (show MRAP Antibodies) in the Turkish population.
HLA-B18 positive patients more frequently had a higher and faster fibrosis progression rate.
Our results suggested, for the first time, that HLA-B*51:01 is a risk allele for clindamycin-related cutaneous adverse drug reactions in Han Chinese, especially when clindamycin is administered via intravenous drip.
HLA-B18 Is risk factor of liver fibrosis progression in HIV/HCV treatment-experienced patients
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
major histocompatibility complex, class I, B
, HLA class I histocompatibility antigen, B alpha chain
, MHC Class I HLA heavy chain
, MHC HLA-B cell surface glycoprotein
, MHC HLA-B transmembrane glycoprotein
, MHC class I antigen GN00104
, MHC class I antigen HLA-B heavy chain
, MHC class I antigen SHCHA
, leukocyte antigen class I-B
, lymphocyte antigen