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anti-Human HLA-B Antibodies:
anti-Mouse (Murine) HLA-B Antibodies:
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Human Polyclonal HLA-B Primary Antibody for WB - ABIN1944779
Little, Parham: The HLA-Bw75 subtype of B15: molecular characterization and comparison with crossreacting antigens. in Tissue antigens 1992
Show all 5 Pubmed References
Human Polyclonal HLA-B Primary Antibody for WB - ABIN516466
Lorente, García, López: Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells. in The Journal of biological chemistry 2011
Show all 3 Pubmed References
The present work showed in West Algerian population that the HLA-B27 (show MRAP Antibodies) antigen and the variation in the CTLA4 (show CTLA4 Antibodies) 3'UTR (show UTS2R Antibodies) region played an important role in the ankylosing spondylitis susceptibility. The heterogeneity of this disease is deduced by genetic difference found between B27 (show MRAP Antibodies)+ and B27 (show MRAP Antibodies)- groups.
results reveal strong evidence that the HLA-B*15:02 polymorphism can induce serious cutaneous reactions among Asian carbamazepine users[review, meta-analysis]
Allelic and haplotype diversity of HLA-A, HLA-B and HLA-DRB1 gene at high resolution in the Nanning Han population.
human leukocyte antigen (show HLADRB4 Antibodies) (HLA)-Bw4 is associated with susceptibility to psoriatic disease (PsD (show PSD Antibodies)), but genetic interactions with their cognate ligand, variably expressed killer cell immunoglobulin like receptor (show KIR2DS1 Antibodies) (KIR) 3DL1 (show KIR3DL1 Antibodies) alleles
The present study was conducted to investigate the key genes and the inflammatory signaling pathways involved in HLA-B27 (show MRAP Antibodies)-associated acute anterior uveitis (AAU) families.
rs12524487 in HLA-B/MICA was a genetic risk factor for Takayasu arteritis in a Chinese Han population and rs9366782 in this region was associated with ischemic brain disease in TA but not TA susceptibility.
this study demonstrates an association between HLA-B alleles and carbamazepine-induced maculopapular exanthema and severe cutaneous reactions in Thai patients
Significant association between the HLA-B*15:02 genotype and the B-75(15) serotype and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Javanese and Sundanese populations.
this study shows that HLA-B genetic variance is associated with HIV-1 viral load in seroconverters from Zambia and Rwanda
This analysis showed that HLA-B*58:01 genetic testing before allopurinol initiation is unlikely to be a cost-effective intervention in Malaysia.
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
major histocompatibility complex, class I, B
, HLA class I histocompatibility antigen, B alpha chain
, MHC Class I HLA heavy chain
, MHC HLA-B cell surface glycoprotein
, MHC HLA-B transmembrane glycoprotein
, MHC class I antigen GN00104
, MHC class I antigen HLA-B heavy chain
, MHC class I antigen SHCHA
, leukocyte antigen class I-B
, lymphocyte antigen