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anti-Human IL27 Receptor alpha Antibodies:
anti-Mouse (Murine) IL27 Receptor alpha Antibodies:
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Human Monoclonal IL27 Receptor alpha Primary Antibody for FACS - ABIN4897457
Kachroo, Lee, Zhang, Baratelli, Lee, Srivastava, Wang, Walser, Krysan, Sharma, Dubinett, Lee: IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer. in Journal of experimental & clinical cancer research : CR 2013
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Human Polyclonal IL27 Receptor alpha Primary Antibody for IHC, ELISA - ABIN1003238
Sprecher, Grant, Baumgartner, Presnell, Schrader, Yamagiwa, Whitmore, OHara, Foster: Cloning and characterization of a novel class I cytokine receptor. in Biochemical and biophysical research communications 1998
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Human Polyclonal IL27 Receptor alpha Primary Antibody for IHC, ELISA - ABIN1003239
Chen, Ghilardi, Wang, Baker, Xie, Gurney, Grewal, de Sauvage: Development of Th1-type immune responses requires the type I cytokine receptor TCCR. in Nature 2000
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Human Polyclonal IL27 Receptor alpha Primary Antibody for ELISA, ICC - ABIN4325023
Morandi, Di Carlo, Ferrone, Petretto, Pistoia, Airoldi: IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation. in Journal of immunology (Baltimore, Md. : 1950) 2014
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Mouse (Murine) Monoclonal IL27 Receptor alpha Primary Antibody for CyTOF, FACS - ABIN4900137
Pradhan, Lambert, Reuther: Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor. in Proceedings of the National Academy of Sciences of the United States of America 2007
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Human Polyclonal IL27 Receptor alpha Primary Antibody for IF (p), IHC (p) - ABIN749498
Xu, Yi, Wang, Hu, Han, Xue, Zhang, Luan: IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations. in Immunologic research 2017
Mouse (Murine) Monoclonal IL27 Receptor alpha Primary Antibody for FACS - ABIN5666540
Mascanfroni, Yeste, Vieira, Burns, Patel, Sloma, Wu, Mayo, Ben-Hamo, Efroni, Kuchroo, Robson, Quintana: IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. in Nature immunology 2013
this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth
These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
Findings demonstrated that IL-27 and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells
The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB.
natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27.
Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes.
TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration.
Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.
WSX-1 is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.
WSX-1 together with the cytokine receptor gp130 constitutes a functional signal-transducing receptor for IL-27.
IL-27R possesses hematopoietic cell-transforming properties
These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130.
Results reveal an interleukin 27-independent function of WSX1 sensitizing natural killer cell-mediated antitumor surveillance.
IL-27 production was elevated during Clostridium difficile infection in humans and mice. Infected WSX-1-/- mice experienced increased weight loss, enhanced colonic histology damage, less Clostridium difficile clearance, and decreased survival compared to wild-type controls during Clostridium difficile infection.
this paper shows that the increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells
show that IL-27R signaling controls endothelial cells activation and myeloid cell recruitment at early and advanced stages of atherosclerosis. In the absence of IL-27R myeloid cells become hyperactivated, produce pro-inflammatory cytokines and act as more potent antigen presenting cells.
data suggested that IL-27/IL-27R expression induced by Toxoplasma gondii infection may regulate mast cell-mediated immune response during acute ocular toxoplasmosis in mouse model
Study reports a high-incidence, low-variation spontaneous mouse model of spondyloarthropathy that delineates how the combination of inflammatory cytokine interleukin-27 (IL-27) signaling deficiency and mitogenic signaling (mutant p53R172H) in vivo, leads to bone loss in the vertebral bodies and ossification of the cartilage in the intervertebral discs.
IL-27 signaling in Foxp3(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system
The combination of mutant p53 & IL27RA(-/-) causes spontaneous liver inflammation, steatosis, and fibrosis, whereas either gene alone has no effects on the liver.
IL-10 production by CD4(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 receptor signaling that is supported after CD4(+) T cell priming by ICOS signaling.
IL-27R-mediated regulation of IL-17 controls the development of respiratory syncytial virus-associated pathogenesis.
CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice
The loss of IL-27R signaling across the whole mouse resulted in reduced viral control and a slight increase in the number of virus-specific CD4 T cells at early stages of viral infection.
Diminution of the Th1 response in infected Il27ra mice in vivo by neutralization of IL-12p40 attenuated CCR5 expression.
These findings establish a novel antiatherogenic role for IL-27 receptor signaling, which acts to suppress the production of proinflammatory cytokines and chemokines and to curb the recruitment of inflammatory myeloid cells into atherosclerotic aortas.
In Th1-dependent autoinflammatory lesions, IL-27Ralpha has a biphasic role in vivo, initially pathogenic, but ultimately playing a protective role by regulating immune responses and attenuating disease.
Data show that the deletion of Il27ra ameliorates pathology in the pristane-induced SLE model.
Findings demonstrate the essential role of IL-27R signaling in regulating effector T cell function during malaria infection and reveal a novel pathway that might be amenable to manipulation by drugs or vaccines.
A novel role is revealed for WSX-1 as an inhibitory regulator of cytokine production and inflammation in Con A-induced hepatitis.
The requirement for WSX-1 signaling in T helper type 1 cell differentiation is restricted to conditions in which IL-4 is produced.
demonstrate an important role for WSX-1 signaling in the promotion of type 1 responses and chronic gastrointestinal nematode infection
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.
interleukin 27 receptor, alpha
, class I cytokine receptor
, interleukin-27 receptor subunit alpha
, type-I T cell cytokine receptor
, IL-27 receptor subunit alpha
, IL-27R subunit alpha
, T-cell cytokine receptor type 1
, cytokine receptor WSX-1
, cytokine receptor-like 1
, type I T-cell cytokine receptor
, T cell cytokine receptor
, T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1
, cytokine receptor family, class 1 (WSXWS), member 1