Browse our anti-CLOCK (CLOCK) Antibodies

Full name:: anti-Clock Homolog (Mouse) Antibodies (CLOCK)

On www.antibodies-online.com are 121 Clock Homolog (Mouse) (CLOCK) Antibodies from 25 different suppliers available. Additionally we are shipping CLOCK Kits (11) and CLOCK Proteins (6) and many more products for this protein. A total of 147 CLOCK products are currently listed.

Synonyms:: 5330400M04Rik, bHLHe8, bHLHe10, CG7391, clk, clock, dClck, dclk, dCLK/JRK, dClock, Dmel\\CG7391, Jerk, jrk, KAT13D, mKIAA0334, PAS1, Xclk, XClock, zCLOCK1, zfCLOCK1

list all antibodies	Gene Name	GeneID	UniProt
	CLOCK	12753	O08785
	CLOCK	60447	Q9WVS9
	CLOCK	9575	O15516
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Top referenced anti-CLOCK Antibodies

Human Polyclonal CLOCK Primary Antibody for ChIP, WB - ABIN151057 : Jin, Shearman, Weaver, Zylka, de Vries, Reppert: A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. in Cell 1999 (PubMed)
Show all 6 Pubmed References
Human Monoclonal CLOCK Primary Antibody for ICC, ELISA - ABIN969059 : Lee, Paik, Kang, Lim, Kim: Allelic variants interaction of CLOCK gene and G-protein beta3 subunit gene with diurnal preference. in Chronobiology international 2007 (PubMed)
Show all 2 Pubmed References
Human Polyclonal CLOCK Primary Antibody for IHC - ABIN965906 : Steeves, King, Zhao, Sangoram, Du, Bowcock, Moore, Takahashi: Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei. in Genomics 1999 (PubMed)
Show all 9 Pubmed References
Human Polyclonal CLOCK Primary Antibody for ELISA, WB - ABIN564129 : Kalamvoki, Roizman: Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
Polyclonal CLOCK Primary Antibody for ChIP, IP - ABIN540419 : Shearman, Weaver: Photic induction of Period gene expression is reduced in Clock mutant mice. in Neuroreport 1999 (PubMed)
Show all 5 Pubmed References

More Antibodies against CLOCK Interaction Partners

Fruit Fly (Drosophila melanogaster) Clock Homolog (Mouse) (CLOCK) interaction partners

experiments define the genetic architecture required to initiate circadian clock function in Drosophila, reveal mechanisms governing circadian activator stability that are conserved in perhaps all eukaryotes, and suggest that Clk, cyc (show COX6C Antibodies), and cry expression is sufficient to drive clock expression in naive cells
propose that the dCLK/CYC (show COX6C Antibodies)-controlled TTFL operates differently in subsets of pacemaker neurons, which may contribute to their specific functions
Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC (show COX6C Antibodies) E-box binding, thus enhancing the removal of CLK-CYC (show COX6C Antibodies) from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC (show COX6C Antibodies) from E-boxes
these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.
Our findings suggest a novel role for clock protein (show ARNTL Antibodies) phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.
These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.
Computational dissection of CLK/CYC (show COX6C Antibodies) context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites
usp8 (show USP8 Antibodies) loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8 (show USP8 Antibodies)-DN) enhances CLK/CYC (show COX6C Antibodies) transcriptional activity and alters fly locomotor activity rhythms
CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation
CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning

Zebrafish Clock Homolog (Mouse) (CLOCK) interaction partners

Data suggest that Clock1a coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 (show SMAD3 Antibodies) signaling; Clock1a alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a activates Smad3a (show SMAD3 Antibodies) promoter via its E-box1 element. (Clock1a = clock circadian regulator a; Nodal = nodal modulator 1 (show NOMO1 Antibodies); Smad3a (show SMAD3 Antibodies) = SMAD (show SMAD1 Antibodies) family member 3a)
effect of CRY (show CRY2 Antibodies) in repressing transcription mediated by CLOCK-BMAL heterodimer

Mouse (Murine) Clock Homolog (Mouse) (CLOCK) interaction partners

Low expression of CLOCK protein (show ARNTL Antibodies) is associated with kidney tumor.
PML (show PML Antibodies) mediates the binding of PER2 (show PER2 Antibodies) to BMAL1 (show ARNTL Antibodies) in the BMAL1 (show ARNTL Antibodies)/CLOCK heterodimer and is an important component in the organization of a functional clock complex in the nucleus.
Data show that CRY1 (show CRY1 Antibodies) binds directly to the PAS (show PASK Antibodies) domain core of CLOCK:BMAL1, driven primarily by interaction with the CLOCK PAS (show PASK Antibodies)-B domain.
CLOCK temporally gates mast cell responses to IL-33 (show IL33 Antibodies) via regulation of ST2 (show SULT2A1 Antibodies) expression. Our findings provide novel insights into IL-33 (show IL33 Antibodies)/mast cell-associated physiology and pathologies.
Study showed that CLOCK can interact with RANBP9 and bind with mRNAs, demonstrating that CLOCK is involved in alternative splicing in spermatogenesis. These results reveal a novel mechanism for CLOCK in spermatogenesis.
TFEB (show TFEB Antibodies) regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1 (show ARNTL Antibodies)
ASS1 (show ASS1 Antibodies) acetylation by CLOCK exhibits circadian oscillation in human cells and mouse liver, possibly caused by rhythmic interaction between CLOCK and ASS1 (show ASS1 Antibodies), leading to the circadian regulation of ASS1 (show ASS1 Antibodies) and ureagenesis.
Disruption of CLOCK protein (show ARNTL Antibodies) alters cortical circuits and leads to generation of focal epilepsy.
Development of Mineralocorticoid receptor (show NR3C2 Antibodies)-mediated cardiac inflammation and fibrosis is dependent on intact signaling by the circadian protein CLOCK.
Clock protein (show ARNTL Antibodies) role in proteasomal and autophagic BMAL1 (show ARNTL Antibodies) degradation and glucose homeostasis

Human Clock Homolog (Mouse) (CLOCK) interaction partners

Rhythmic luciferase activity from clock gene luciferase reporter cells lines was used to test the effect of p38 MAPK (show MAPK14 Antibodies) inhibition on clock properties as determined using the damped sine fit and Levenberg-Marquardt algorithm.Glioma treatment with p38 MAPK (show MAPK14 Antibodies) inhibitors may be more effective and less toxic if administered at the appropriate time of the day.
Results indicated that inhibiting the circadian gene Clock expression can reverse the cisplatin resistance of ovarian cancer SKOV3/DDP (show TIMM8A Antibodies) cell lines by affecting the protein expression of drug resistance genes during which autophagy plays an important role.
Low expression of CLOCK protein (show ARNTL Antibodies) is associated with kidney tumor.
Association between HCRTR2, ADH4,CLOCK gene polymorphisms and cluster headache was not significant in the present study.
Study found three gene variants (CLOCK-rs4864548, PEMT (show PEMT Antibodies)-rs936108, and GHRELIN (show GHRL Antibodies)-rs696217) that exhibited uncorrected gene-by-sleep duration interactions in relation to BMI z-scores in a cohort of New Zealand European children. However, no interactions were identified in percentage body fat differences. Notably, these interactions are evident without detectable effects on sleep duration.
These findings suggest that upregulation of the circadian gene hClock plays an important role in metastasis of colorectal cancer.
results of this study suggest that genetic variability in the ARNTL (show ARNTL Antibodies) and CLOCK genes might be associated with risk for multiple sclerosis
CLOCK rs1801260*C and PER3(4/4) influence myelination processes by regulating sleep quality and quantity.
TFEB (show TFEB Antibodies) regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1 (show ARNTL Antibodies)
Our findings suggest that CLOCK and CRY1 polymorphisms might be involved in individual susceptibility to abdominal obesity in Chinese Han population.

Xenopus laevis Clock Homolog (Mouse) (CLOCK) interaction partners

the second half of the photolyase homology region (PHR) of CRY (show CRY2 Antibodies) is important for repression through facilitating interaction with CLOCK

CLOCK Antigen Profile

Antigen Summary

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CLOCK

Clock (Clk) antibody
clock circadian regulator (CLOCK) antibody
clock homolog (mouse) (CLOCK) antibody
clock circadian regulator (clock) antibody
clock circadian regulator a (clocka) antibody
circadian locomotor output cycles kaput (Clock) antibody
clock circadian regulator (Clock) antibody
clock circadian regulator L homeolog (clock.L) antibody

5330400M04Rik antibody
bHLHe8 antibody
bHLHe10 antibody
CG7391 antibody
clk antibody
clock antibody
dClck antibody
dclk antibody
dCLK/JRK antibody
dClock antibody
Dmel\\CG7391 antibody
Jerk antibody
jrk antibody
KAT13D antibody
mKIAA0334 antibody
PAS1 antibody
Xclk antibody
XClock antibody
zCLOCK1 antibody
zfCLOCK1 antibody

Protein level used designations for CLOCK

, , , , , , , , , , , , , , , , , , , , , , , , CG7391-PA CG7391-PD CG7391-PF CG7391-PG CG7391-PH CLOCK Clk-PA Clk-PD Clk-PF Clk-PG Clk-PH clock dClock clock homolog (mouse) clock homolog circadian locomoter output cycles protein kaput circadian locomoter output cycles protein kaput-like Clock1a clk1 circadian locomoter output cycles kaput mCLOCK rCLOCK circadian locomoter output cycles kaput protein class E basic helix-loop-helix protein 8 circadian rhythmicity protein CLOCK

GENE ID	SPECIES
38872	Drosophila melanogaster
461312	Pan troglodytes
475145	Canis lupus familiaris
786637	Bos taurus
100008576	Meleagris gallopavo
100017022	Monodelphis domestica
100034166	Equus caballus
100038163	Xenopus (Silurana) tropicalis
100171391	Ovis aries
100172630	Pongo abelii
100349684	Oryctolagus cuniculus
100407407	Callithrix jacchus
30140	Danio rerio
100606130	Nomascus leucogenys
100628097	Sus scrofa
12753	Mus musculus
60447	Rattus norvegicus
9575	Homo sapiens
399157	Xenopus laevis
373991	Gallus gallus

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Show all anti-Clock Homolog (Mouse) (CLOCK) Antibodies with Pubmed References