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p-SMAD2 (show SMAD2 Proteins)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (show TGFB1 Proteins) induced CTGF exp p-SMAD2 (show SMAD2 Proteins)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (show TGFB1 Proteins) induced CTGF expression during tooth development.
Ctgf is the direct target gene of SOX9 (show SOX9 Proteins) in chondrocytes and nucleus pulposus cells.
As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiog (show VEGFC Proteins)enesis through regulation of, and direct interaction with, VEGF-C.
CTGF and BMP2 (show BMP2 Proteins) are induced following myocardial ischemia in mice and humans.
this study suggested that CTGF antibody protected podocytes against injury in DN mice by reducing beta-catenin (show CTNNB1 Proteins) overexpression and preventing podocyte EMT (show ITK Proteins), which might provide new insight into the mechanism of CTGF inhibition in the treatment of DN.
LPA-LPA1 (show LPAR1 Proteins) signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.
Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results.
CTGF role in cardiac fibrosis. Long noncoding RNA H19 (show NCKAP1 Proteins) mediates CTGF expression.
Notch1 (show NOTCH1 Proteins) haploinsufficiency decreased the expression of Ctgf in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 (show NOTCH1 Proteins) intracellular domain (NICD (show NOTCH1 Proteins)) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1 (show NOTCH1 Proteins), not Notch3 (show NOTCH3 Proteins), directly modulates the expression of CTGF
these findings show that cardiac ERK1/2 activity is modulated in part by TGF-b/Smad (show SMAD1 Proteins) signaling, leading to altered activation of CTGF/CCN2 to mediate fibrosis and alter cardiac function. This identifies a novel mechanism in the development of LMNA (show LMNA Proteins) cardiomyopathy.
Connective tissue growth factor (CTGF) is an important mediator of renal allograft fibrosis, and urinary CTGF (CTGFu) levels correlate with the development of allograft interstitial fibrosis. We evaluated the predictive value of CTGF protein expression in 160 kidney transplant recipients with paired protocol biopsies at 3 months and 5 years after transplantation.
Lymphangiogenesis during tubulointerstitial fibrosis to be associated with increased expression of CTGF and VEGF-C (show VEGFC Proteins) in human obstructed nephropathy as well as in diabetic kidney disease. vitro, CTGF induced VEGF-C (show VEGFC Proteins) production in HK-2 (show HK2 Proteins) cells, while CTGF siRNA suppressed transforming growth factor beta1-induced VEGF-C (show VEGFC Proteins) upregulation.
miR132 may target CTGF in regulating fibrosis in Ang (show ANG Proteins) IItreated cardiac fibroblasts.
CTGF-mediated temozolomide resistance in glioblastoma operates through TGF-beta1 (show TGFB1 Proteins)-dependent activation of Smad (show SMAD1 Proteins)/ERK (show EPHB2 Proteins) signaling pathways
CCN2 plays a promoting role in hepatocellular carcinoma (HCC (show FAM126A Proteins))progression through activating LRP6 (show LRP6 Proteins) in a HSPGs-dependent manner. Heparin in combination with chemotherapy has a synergic effect and could be a treatment choice for HCCs (show HCCS Proteins) with a high CCN2 expression.
real-time polymerase chain reaction showed higher expression levels of TGF-beta (show TGFB1 Proteins) and CTGF in desmoid fibromatosis compared with normal skin. The high constitutive expression of beta-catenin (show CTNNB1 Proteins) downstream effectors; TGF-beta (show TGFB1 Proteins), CTGF has the potential for enabling targeted therapy
results demonstrated that mechanical stretch and CoCl2-induced HIF-1alpha (show HIF1A Proteins) together increased the level of MMP-2 (show MMP2 Proteins) and decreased the levels of VEGF (show VEGFA Proteins) and CTGF in cultured ACL (show ACLY Proteins) fibroblasts.
Smurf2 (show SMURF2 Proteins), an E3 ubiquitin ligase (show MUL1 Proteins), interacts with PDE4B (show PDE4B Proteins) and attenuates liver fibrosis through miR (show MLXIP Proteins)-132 mediated CTGF inhibition
the up-regulation of CTGF expression by visfatin (show NAMPT Proteins) might be mediated via HIF-1a (show HIF1A Proteins) -dependent pathway, but not the TGF-b1 pathway in EAHy926 cells
The results indicate that CTGF suppresses the synthesis of biglycan (show BGN Proteins) but newly induced that of decorin (show DCN Proteins) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (show SOX2 Proteins)-, GFAP (show GFAP Proteins)-and GFAP (show GFAP Proteins)/Nestin (show NES Proteins)-positive cells, activated p44 (show GTF2H2 Proteins)/42 signaling, and upregulated fibronectin (show FN1 Proteins). In human glioma cells, it induced GFAP (show GFAP Proteins) and nestin (show NES Proteins).
Data show that connective-tissue growth factor regulates signalling through the Wnt (show WNT2 Proteins) pathway, in accord with its ability to bind to the Wnt (show WNT2 Proteins) co-receptor LDL receptor (show LDLR Proteins)-related protein 6 (LRP6 (show LRP6 Proteins)).
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
A significant increase in TGF-beta1 (show TGFB1 Proteins) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (show TGFB1 Proteins) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor
, connective tissue growth factor XCTGF
, Connective tissue growth factor
, connective tissue growth factor-like