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early myocardial CTGF mRNA expression (six hours) after Ang-II (show AGT Proteins) exposure is likely dependent on latent TGF-beta (show TGFB1 Proteins) activation via the canonical Smad (show SMAD1 Proteins)-dependent pathway in resident cardiac cells.
These results indicate that the hepatocytic expression of TGF-beta (show TGFB1 Proteins) and CTGF is mediated by Wnt (show WNT2 Proteins) signalling in Schistosoma japonicum infection.
Data (including data from studies using transgenic mice) suggest that Ctgf secreted from vascular endothelium in pancreas plays critical role in up-regulation of insulin (show INS Proteins) secretion in pancreatic beta-cells during pregnancy; here, pregnant mice with global Ctgf haplo-insufficiency (heterozygous for loss-of-function mutation) (a) exhibit impairment in maternal beta-cell proliferation and (b) develop gestational diabetes.
The data demonstrate that MMP13 (show MMP13 Proteins) and CTGF play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis.
p-SMAD2 (show SMAD2 Proteins)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (show TGFB1 Proteins) induced CTGF exp p-SMAD2 (show SMAD2 Proteins)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (show TGFB1 Proteins) induced CTGF expression during tooth development.
Ctgf is the direct target gene of SOX9 (show SOX9 Proteins) in chondrocytes and nucleus pulposus cells.
As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiog (show VEGFC Proteins)enesis through regulation of, and direct interaction with, VEGF-C.
CTGF and BMP2 (show BMP2 Proteins) are induced following myocardial ischemia in mice and humans.
this study suggested that CTGF antibody protected podocytes against injury in DN mice by reducing beta-catenin (show CTNNB1 Proteins) overexpression and preventing podocyte EMT (show ITK Proteins), which might provide new insight into the mechanism of CTGF inhibition in the treatment of DN.
LPA-LPA1 (show LPAR1 Proteins) signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.
Down-regulation of CTGF could markly decrease proliferation.
PVT1 was able to bind and degrade miR26b to promote connective tissue growth factor (CTGF) and angiopoietin 2 (ANGPT2 (show ANGPT2 Proteins)) expression.
CTGF can reduce glycolysis and mitochondrial OXPHOS pathways by increasing mtTFA (show TFAM Proteins) protein degradation and in turn reduces cancer migration and invasion in oral squamous cell carcinoma (OSCC).
Results show that mRNA and serum expression levels of Cyr61 (show CYR61 Proteins), CTGF, and VEGF (show VEGFA Proteins) in muscle tissues of patients with polymyositis (PM)/dermatomyositis (DM). These data suggest that these genes may be involved in the pathogenesis mainly by affecting the formation of blood vessels and promoting inflammatory response.
This study study discovered a positive feedback loop between CTGF and CCL18 (show CCL18 Proteins) in hepatocellular carcinoma metastasis.
Serum connective tissue growth factor (CTGF) is a promising diagnostic biomarker for rheumatoid arthritis (RA).
Connective tissue growth factor (CTGF) is an important mediator of renal allograft fibrosis, and urinary CTGF (CTGFu) levels correlate with the development of allograft interstitial fibrosis. We evaluated the predictive value of CTGF protein expression in 160 kidney transplant recipients with paired protocol biopsies at 3 months and 5 years after transplantation.
Lymphangiogenesis during tubulointerstitial fibrosis to be associated with increased expression of CTGF and VEGF-C (show VEGFC Proteins) in human obstructed nephropathy as well as in diabetic kidney disease. vitro, CTGF induced VEGF-C (show VEGFC Proteins) production in HK-2 (show HK2 Proteins) cells, while CTGF siRNA suppressed transforming growth factor beta1-induced VEGF-C (show VEGFC Proteins) upregulation.
miR132 may target CTGF in regulating fibrosis in Ang (show ANG Proteins) IItreated cardiac fibroblasts.
CTGF-mediated temozolomide resistance in glioblastoma operates through TGF-beta1 (show TGFB1 Proteins)-dependent activation of Smad (show SMAD1 Proteins)/ERK (show EPHB2 Proteins) signaling pathways
Results confirm the prodevelopmental actions of activin A (show INHBA Proteins) and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF (show HGF Proteins) were inhibitory to development.
The results indicate that CTGF suppresses the synthesis of biglycan (show BGN Proteins) but newly induced that of decorin (show DCN Proteins) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (show SOX2 Proteins)-, GFAP (show GFAP Proteins)-and GFAP (show GFAP Proteins)/Nestin (show NES Proteins)-positive cells, activated p44 (show GTF2H2 Proteins)/42 signaling, and upregulated fibronectin (show FN1 Proteins). In human glioma cells, it induced GFAP (show GFAP Proteins) and nestin (show NES Proteins).
Data show that connective-tissue growth factor regulates signalling through the Wnt (show WNT2 Proteins) pathway, in accord with its ability to bind to the Wnt (show WNT2 Proteins) co-receptor LDL receptor (show LDLR Proteins)-related protein 6 (LRP6 (show LRP6 Proteins)).
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
A significant increase in TGF-beta1 (show TGFB1 Proteins) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (show TGFB1 Proteins) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor
, connective tissue growth factor XCTGF
, Connective tissue growth factor
, connective tissue growth factor-like