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Human Monoclonal HAVCR2 Primary Antibody for FACS - ABIN4896442
Tandon, Giret, Sengupta, York, Wiznia, Rosenberg, Kallas, Ndhlovu, Nixon: Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children. in PLoS ONE 2012
Show all 22 Pubmed References
Human Polyclonal HAVCR2 Primary Antibody for CyTOF, FACS - ABIN4899649
Moller-Tank, Albritton, Rennert, Maury: Characterizing functional domains for TIM-mediated enveloped virus entry. in Journal of virology 2014
Show all 13 Pubmed References
Human Monoclonal HAVCR2 Primary Antibody for FACS - ABIN4896438
Raziorrouh, Heeg, Kurktschiev, Schraut, Zachoval, Wendtner, Wächtler, Spannagl, Denk, Ulsenheimer, Bengsch, Pircher, Diepolder, Grüner, Jung: Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules. in PLoS ONE 2014
Show all 8 Pubmed References
Human Monoclonal HAVCR2 Primary Antibody for CyTOF, FACS - ABIN4899648
Hertoghs, Moerland, van Stijn, Remmerswaal, Yong, van de Berg, van Ham, Baas, ten Berge, van Lier: Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. in The Journal of clinical investigation 2010
Show all 6 Pubmed References
Human Polyclonal HAVCR2 Primary Antibody for WB - ABIN1881402
Cao, Zhu, Zhu, Li, Zhang, Xu, Zhang: Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer. in Cancer immunology, immunotherapy : CII 2010
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Mouse (Murine) Monoclonal HAVCR2 Primary Antibody for FACS - ABIN4896159
Yadav, Jhunjhunwala, Phung, Lupardus, Tanguay, Bumbaca, Franci, Cheung, Fritsche, Weinschenk, Modrusan, Mellman, Lill, Delamarre: Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. in Nature 2014
Show all 3 Pubmed References
Mouse (Murine) Monoclonal HAVCR2 Primary Antibody for FACS - ABIN4896162
Cho, Roche, Sandall, Brass, Seed, Xavier, Medoff: Enhanced Tim3 activity improves survival after influenza infection. in Journal of immunology (Baltimore, Md. : 1950) 2012
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Human Monoclonal HAVCR2 Primary Antibody for FACS - ABIN4896439
Lasso, Mateus, Pavía, Rosas, Roa, Thomas, López, González, Puerta, Cuéllar: Inhibitory Receptor Expression on CD8+ T Cells Is Linked to Functional Responses against Trypanosoma cruzi Antigens in Chronic Chagasic Patients. in Journal of immunology (Baltimore, Md. : 1950) 2015
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Mouse (Murine) Polyclonal HAVCR2 Primary Antibody for CyTOF, FACS - ABIN4899644
Koh, Chang, Jeon, Yoon, Ahn, Kim, Kim, Jeon, Johnson, Park: The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia. in Nature communications 2015
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Mouse (Murine) Monoclonal HAVCR2 Primary Antibody for IHC (fro), FACS - ABIN2476818
Warner: Tobacco industry scientific advisors: serving society or selling cigarettes? in American journal of public health 1991
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The Tim-3/Gal-9 (show LGALS9 Antibodies) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
the CD4 (show CD4 Antibodies)(+)CD25 (show IL2RA Antibodies)(+)Foxp3 (show FOXP3 Antibodies)(+) Treg cells from RA patients demonstrated a reduction of Tim3 and were less functional than Treg cells from healthy controls in a Tim3-related manner.
our study highlights the role of TIM-3 as a potential prognostic marker and a promising therapeutic target in solid tumors.
HAVCR2 regulates cytokines, chemokines, prostaglandins and cell adhesion molecules in the presence of viral infection, which suggests a potential for HAVCR2 activators as therapeutics for the management of preterm birth associated with viral infections.
Preoperative Tim3 expression on peripheral NK cells is correlated with differential staging in colorectal cancer, and may be useful as a serum biomarker.
TIM-3 polymorphism is associated with response to therapy in hepatitis B virus-related hepatocellular carcinoma.
BMI-1 (show BMI1 Antibodies), TIM-3 and CLL-1 (show COLEC10 Antibodies) have roles in acute myeloid leukemia (show BCL11A Antibodies) prognosis and therapy
Quantification of TIM-3 and KIM-1 (show HAVCR1 Antibodies) mRNA expressions, along with KIM-1 (show HAVCR1 Antibodies) protein measurements in urine and blood could be employed as promising tools for noninvasive diagnosis of allograft dysfunction.
Results show that human acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) cells possess a secretory pathway which leads to the production and release of soluble Tim-3 and galectin-9 (show LGALS9 Antibodies). Both proteins prevent the activation of NK cells and impair their AML (show RUNX1 Antibodies) cell-killing activity.
after 14 days of glucocorticoid therapy, clinical findings (serum bilirubin, skin GVHD) and plasma biomarkers (TIM3, ST2, sTNFR1) can predict failure of GVHD treatment and nonrelapse mortality.
These findings suggested that rs10053538 in TIM-3 might increase susceptibility to and promote the progression of breast cancer in Chinese women
CB2R (show CNR2 Antibodies) may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1alpha (show HIF1A Antibodies)/TIM-3 signalling pathway in microglia
Our results show that Tim-3 is a critical negative regulator of NLRP3 (show NLRP3 Antibodies) inflammasome and provides a potential target for intervention of diseases with uncontrolled inflammasome activation.
demonstrated that both IL-10 (show IL10 Antibodies) and TGF-beta (show TGFB1 Antibodies) upregulated TIM-3 surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src (show SRC Antibodies) and Bruton's tyrosine kinase (show BTK Antibodies)
Methylation level of the TIM-3 promoter gradually decreased after each round of T-cell polarization, and this decrease was inversely correlated with TIM-3 expression.
in mice, TIM-3 is not essential for development of HDM (show HDAC3 Antibodies)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (show HDAC3 Antibodies)-induced chronic allergic airway inflammation.
Authors found that a CD8 (show CD8A Antibodies)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.
TIM4 (show TIMD4 Antibodies) binds TIM3 on the surface of polarized Th1 (show HAND1 Antibodies) cells to induce Th1 (show HAND1 Antibodies) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
The Gal-9 (show LGALS9 Antibodies)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN Antibodies) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A Antibodies) ligation.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog