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Browse our MED23 Proteins (MED23)

Full name:: Mediator Complex Subunit 23 Proteins (MED23)

On www.antibodies-online.com are 4 Mediator Complex Subunit 23 (MED23) Proteins from 3 different suppliers available. Additionally we are shipping MED23 Antibodies (68) and MED23 Kits (11) and many more products for this protein. A total of 89 MED23 products are currently listed.

Synonyms:: 130kDa, 3000002A17Rik, ARC130, CG3695, crsp3, CRSP130, CRSP133, Dmel\\CG3695, DRIP130, dSUR2, dTRAP150beta, ESTM7, Gal11/SUR2, MED23, mKIAA1216, MRT18, si:ch211-272f15.2, SUR-2, Sur2, Trap150, Trap150beta, X83317, zgc:91979

list all proteins	Gene Name	GeneID	UniProt
	MED23	9439	Q9ULK4
	MED23	70208	Q80YQ2
	MED23	309565
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MED23 Proteins (MED23) by Origin

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Relevant Pathways for MED23 Proteins

Regulation of Lipid Metabolism by PPARalpha

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Human Mediator Complex Subunit 23 (MED23) interaction partners

Mutational Heterogeneity of MED23 Gene in Colorectal Cancers.
MED23 adopts an arch-shaped conformation, with an N-terminal domain (Nter) protruding from a large core region.
This is the first patient with documented refractory epilepsy caused by a novel homozygous pathogenic variant in MED23 expanding the phenotypic spectrum. Identification of the underlying genetic defect in MED23 sheds light on the possible mechanism of complete response to the ketogenic diet in this child.
a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8
Higher l-arginine was associated with higher risk of Ischemic heart disease (odds ratio and of myocardial infarction, based on 2 SNPs from MED23.
MED23-associated intellectual disability has been found in two brothers from a non-consanguineous family.
MED23 plays an important role in hepatocarcinogenesis, and it may be a novel target for HCC therapy.
Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells.
Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb.
Data show that Med23 RNAi specifically inhibits the proliferation and tumorigenicity of lung cancer cells with hyperactive Ras activity.
missense mutation (p. R617Q) in MED23 that cosegregates with nonsyndromic autosomal recessive intellectual disability; mutation impaired response of JUN and FOS to mitogens by altering interaction between enhancer-bound transcription factors and Mediator
DRIP130 regulates HER2 expression by binding to ESX
loss of DRIP-130 expression, as a result of the gross loss of human chromosome 6q16.3-q23, provokes increased tumor metastasis
Sur2(CRSP3) is required for activation by Adenovirus E1A CR3 activation domain and is required for MAPK-mediated activation of Elk-1.

Mouse (Murine) Mediator Complex Subunit 23 (MED23) interaction partners

Study identifies Med23 as an essential transcriptional regulator that controls invariant natural killer T-cells differentiation and terminal maturation.
Findings identify Med23 as a gatekeeper of myeloid potential of HSCs, thus providing unique insights into the relationship among Med23-mediated transcriptional regulations, the myeloid potential of HSCs and HSC activation upon stresses.
MED23 constitutes a molecular node in the regulatory network of anabolic bone formation and related diseases.
Med23 contributes to controlling T-cell activation at the transcriptional level and prevents the development of autoimmunity.
The hepatic Med23 deletion impaired the Mediator and RNAPII recruitment and attenuated the expression of FOXO1 target genes.
Data show that Kruppel-like transcription factors KLF2 expression is decreased in mediator complex Med23 null thymocytes.
Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling.
Reduced expression of MED23 inhibits cell apoptosis by downregulation of Bax, activated Caspase 3, activated Caspase 9 and upregulation of cyclinD1 and Bcl2.
Data show tha tMed23 deficiency in fibroblasts selectively inhibited the oncogenic transformation induced by Ras.
Mediator MED23 controls the cell fate preference that directs differentiation into smooth muscle cells (SMCs) or adipocytes
MED23 regulates a subset of hnRNP L-targeted alternative splicing (AS) and alternative cleavage and polyadenylation (APA) events.
MED23 Mediator controls Egr1 gene and stimulates Pol II initiation at a step subsequent to preinitiation complex assembly
Data show that Med23 knockout nearly eliminates Egr1 transcription in embryonic stem cells, but not in fibroblasts.
Results suggest that Med23 serves as a critical link transducing insulin signaling to the transcriptional cascade during adipocyte differentiation.

Caenorhabditis elegans (C. elegans) Mediator Complex Subunit 23 (MED23) interaction partners

we investigate orthologs of a transcription complex that acts in mammalian EGFR signaling-lin-1/Elk1, sur-2/Med23, and the Cdk8 Kinase module (CKM).our analysis using cell fate reporters reveals that both EGFR and LIN-12/Notch signal transduction pathways are active in all VPCs in lin-1/Elk1 mutants
Study shows that sur-2 mutation affects the Cbr-sur-2/MED23 gene that is orthologous to a C. elegans gene critical for the normal response to the EGF signal. whereas Cel-sur-2 mutants exhibit a reduced vulval development because of defects in the VPC immediately adjacent to the anchor cell (the P6.p cell), similar defects in Caenorhabditis briggsae -sur-2 mutants do not have the same impact.

MED23 Protein Profile

Protein Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with MED23

Mediator complex subunit 23 (MED23)
mediator complex subunit 23 (MED23)
mediator complex subunit 23 (med23)
mediator of RNA polymerase II transcription subunit 23 (LOC412332)
mediator complex subunit 23 (Med23)
mediator complex subunit 23 L homeolog (med23.L)
Mediator of RNA polymerase II transcription subunit 23 (sur-2)

130kDa protein
3000002A17Rik protein
ARC130 protein
CG3695 protein
crsp3 protein
CRSP130 protein
CRSP133 protein
Dmel\\CG3695 protein
DRIP130 protein
dSUR2 protein
dTRAP150beta protein
ESTM7 protein
Gal11/SUR2 protein
MED23 protein
mKIAA1216 protein
MRT18 protein
si:ch211-272f15.2 protein
SUR-2 protein
Sur2 protein
Trap150 protein
Trap150beta protein
X83317 protein
zgc:91979 protein

Protein level used designations for MED23

, , , , , , , , , , , , , , , , , , , CG3695-PA CG3695-PB MED23-PA MED23-PB mediator complex subunit 23 mediator complex subunit n23 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa Sp1 transcriptional activation cofactor subunit 3 mediator of RNA polymerase II transcription subunit 23-like mediator of RNA polymerase II transcription subunit 23 130 kDa transcriptional co-activator 133 kDa transcriptional co-activator activator-recruited cofactor 130 kDa component cofactor required for Sp1 transcriptional activation subunit 3 vitamin D3 receptor interacting protein CRSP complex subunit 3 cofactor required for Sp1 transcriptional activation, subunit 3 (130kD) mSur-2 protein sur-2 homolog cofactor required for Sp1 transcriptional activation, subunit 3

GENE ID	SPECIES
37639	Drosophila melanogaster
426927	Gallus gallus
472124	Pan troglodytes
474822	Canis lupus familiaris
100067556	Equus caballus
100342894	Oryctolagus cuniculus
100409950	Callithrix jacchus
100433008	Pongo abelii
100545205	Meleagris gallopavo
100562268	Anolis carolinensis
100602785	Nomascus leucogenys
412332	Apis mellifera
100466100	Ailuropoda melanoleuca
9439	Homo sapiens
70208	Mus musculus
309565	Rattus norvegicus
445483	Danio rerio
399060	Xenopus laevis
513610	Bos taurus
173345	Caenorhabditis elegans

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