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anti-Human SP1 Antibodies:
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Human Polyclonal SP1 Primary Antibody for ChIP, WB - ABIN2668968
Wang, Mayhew, Chen, Johnston, Mitra: "Calling cards" for DNA-binding proteins in mammalian cells. in Genetics 2012
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Human Polyclonal SP1 Primary Antibody for ChIP, ICC - ABIN153171
Gui, Song, Han, Zhou, Sheu: Involvement of the GC-rich sequence and specific proteins (Sp1/Sp3) in the basal transcription activity of neurogranin gene. in Biochemical and biophysical research communications 2006
Show all 4 Pubmed References
Human Polyclonal SP1 Primary Antibody for IHC (p), IP - ABIN153172
Lay, Hong, Huang, Yang, Pao, Liu, Lai, Lai, Cheng, Su, Chuang: Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL. in Cancer research 2007
Show all 3 Pubmed References
Human Polyclonal SP1 Primary Antibody for ELISA, WB - ABIN250563
Sakuntabhai, Turbpaiboon, Casadémont, Chuansumrit, Lowhnoo, Kajaste-Rudnitski, Kalayanarooj, Tangnararatchakit, Tangthawornchaikul, Vasanawathana, Chaiyaratana, Yenchitsomanus, Suriyaphol, Avirutnan et al.: A variant in the CD209 promoter is associated with severity of dengue disease. ... in Nature genetics 2005
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Human Monoclonal SP1 Primary Antibody for WB - ABIN1944791
Takahara, Kanazu, Yanagisawa, Akanuma: Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing. in The Journal of biological chemistry 2000
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Human Polyclonal SP1 Primary Antibody for ELISA, WB - ABIN562963
: in 1970
Human Polyclonal SP1 Primary Antibody for IP, WB - ABIN2476560
Stark, Assaraf: Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier. in Blood 2006
Human Polyclonal SP1 Primary Antibody for IF (p), IHC (p) - ABIN730468
Peng, Shi, Du, Wang, Klocker, Mo, Mo, Zhang: Prostaglandin E2 induces stromal cell-derived factor-1 expression in prostate stromal cells by activating protein kinase A and transcription factor Sp1. in The international journal of biochemistry & cell biology 2013
A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Antibodies), sp1 and sod1 (show SOD1 Antibodies) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
these findings demonstrate that p53 (show TP53 Antibodies) can repress MCAK (show KIF2C Antibodies) promoter activity indirectly via down-regulation of Sp1 (show PSG1 Antibodies) expression level, and suggest that MCAK (show KIF2C Antibodies) elevation in human tumor cells might be due to p53 (show TP53 Antibodies) mutation
Our study provides new evidence that interaction of KLF6 and Sp1 regulates basigin-2 expression in hepatocellular carcinoma
Our study showed there was a positive correlation between Sp1 (show PSG1 Antibodies) and COX2 (show COX2 Antibodies) expression in pancreatic ductal adenocarcinoma
Data indicate the Sp1 (show PSG1 Antibodies) oncogene (show RAB1A Antibodies) functions as a positive regulator for BCR/ABL (show ABL1 Antibodies) expression.
This result indicates that the formation of copper-finger protein of Sp1 (show PSG1 Antibodies) is the molecular basis of copper sensing for the transcriptional regulation of hCtr1 (show SLC31A1 Antibodies) in mammalian cells.
Data show that SOX9 (show SOX9 Antibodies) regulates CEACAM1 (show CEACAM1 Antibodies) primarily via Sp1 (show PSG1 Antibodies) and ETS1 (show ETS1 Antibodies).
Sp1 (show PSG1 Antibodies), Sp3 (show SP3 Antibodies) and Sp4 are non-oncogene (show RAB1A Antibodies) addiction (NOA (show DLAT Antibodies)) genes and are attractive drug targets for individual and combined cancer chemotherapies.
lnc AGAP2 (show AGAP2 Antibodies)-AS1 (show PTGDR Antibodies) upregulated by SP1 (show PSG1 Antibodies) plays an important role in gastric cancer development and progression by suppressing P21 (show CDKN1A Antibodies) and E-cadherin (show CDH1 Antibodies)
High SP1 (show PSG1 Antibodies) expression is associated with obesity.
The up-regulation of Hsp27 (show HSPB1 Antibodies) by E2 is mediated by ERalpha (show ESR1 Antibodies)/Sp1 (show PSG1 Antibodies).
study demonstrates the co-expression of DLX3 (show DLX3 Antibodies), PPARG (show PPARG Antibodies) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH Antibodies) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN (show FASN Antibodies) promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP Antibodies) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Antibodies) promoter and its activity.
The Genomic Context and Corecruitment of SP1 Affect ERRalpha (show ESRRA Antibodies) Coactivation by PGC-1alpha (show PPARGC1A Antibodies) in Muscle Cells
These results suggest that Sp1 regulates gene expression of AACS (show AACS Antibodies) in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.
the results obtained in this study show that Znf179 (show RNF112 Antibodies) autoregulation through Sp1-dependent mechanism plays an important role in neuroprotection, and NGF (show NGFB Antibodies)-induced Sp1 signaling may help attenuate more extensive (ROS (show ROS1 Antibodies)-induced) damage following brain injury
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (show NFATC1 Antibodies) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (show MLXIP Antibodies)-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (show SIRT1 Antibodies) signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 (show SP3 Antibodies) to it, leading to p300 (show NOTCH1 Antibodies) recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 (show TLR5 Antibodies) expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3 (show SP3 Antibodies)-mediated gene regulation that may apply to other genes
adrenergic stimulation induced complex formation between Ifrd1 (show IFRD1 Antibodies), Sp1 and mSIN3B, which is a component of the SIN (show POLR3E Antibodies) complex containing histone deacetylase (show HDAC1 Antibodies), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (show IFRD1 Antibodies) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Dp71 (show DMD Antibodies) expression in hepatic cells is carried out, in part, by YY1 (show YY1 Antibodies)-, Sp1- and Sp3 (show SP3 Antibodies)-mediated transcription from the Dp71 (show DMD Antibodies) promoter.
SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1