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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 and sod1 (show SOD1 Proteins) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
our study demonstrates that Sp1 is a major regulator in SRY (show SRY Proteins) gene transcription, and mutations of the Sp1 binding sites (Sp1-B and Sp1-C) in the 5' flanking region of SRY (show SRY Proteins) induce sex reversal in rabbits
The Sp1 (show PSG1 Proteins)-mediaded allelic regulation of MMP13 (show MMP13 Proteins) expression by an esophageal squamous cell carcinoma susceptibility SNP rs2252070 has been demonstrated.
Methylated +322-327 CpG site in the hOGG1 5'-UTR is associated with reduced expression of hOGG1 by decreasing the recruitment of Sp1 to the 5'-UTR of hOGG1 in A549 cells.
that miR (show MLXIP Proteins)-22 and Sp1 (show PSG1 Proteins) form a double-negative feedback loop and consequently activation of PTEN, leading to a decline of p-AKT (show AKT1 Proteins) which influences the biological features of cells
SP1 (show PSG1 Proteins) is an important component of the transcriptional complex and LGR5 (show LGR5 Proteins) activity, which is modulated by its ligands RSPO1 (show RSPO1 Proteins) and RSPO2 (show RSPO2 Proteins), whose expression is modulated by methylation in gastrric carcinogenesis.
we proposed a model to link FXR (show NR1H4 Proteins) to Sp1 (show PSG1 Proteins), which included triggered FXR (show NR1H4 Proteins), p38/MAPK (show MAPK14 Proteins) and/or PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling and phosphorylated Sp1 (show PSG1 Proteins), to illustrate the potential crosstalk between the two factors.
Results found that Sp1 (show PSG1 Proteins) could activate miR (show MLXIP Proteins)-205 expression by binding to its promoter region in response to ionizing radiation in esophageal squamous cell carcinoma.
miR (show MLXIP Proteins)-29c suppressed MGMT (show MGMT Proteins) expression indirectly via targeting specificity protein 1
miR (show MLXIP Proteins)-29c overexpression could abrogate the tumor progression and inhibit the Sp1 (show PSG1 Proteins)/TGF-beta (show TGFB1 Proteins) expressions in vivo, indicating that miR (show MLXIP Proteins)-29c could be a tumor suppressor and repress the Sp1 (show PSG1 Proteins)/TGF-beta (show TGFB1 Proteins) axis-induced EMT (show ITK Proteins) in lung cancer.
Simultaneous high expression of PLD1 and Sp1 (show PSG1 Proteins) predicts a poor prognosis for pancreatic ductal adenocarcinoma patients.
Specificity protein 1 (Sp1) orchestrates the transcription of both VEGF (show VEGFA Proteins) and VEGFR2 (show KDR Proteins); hence, Sp1 (show PSG1 Proteins) could act as a therapeutic target. Here, we demonstrate that CF3DODA-Me induced apoptosis, degraded Sp1 (show PSG1 Proteins), inhibited the expression of multiple drivers of the blebbishield emergency program such as VEGFR2 (show KDR Proteins), p70S6K (show RPS6KB1 Proteins), and N-Myc (show MYCN Proteins) through activation of caspase-3 (show CASP3 Proteins), inhibited reactive oxygen species; and inhibited K-Ras (show HRAS Proteins) activation to abolis
study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG (show PPARG Proteins) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH Proteins) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP Proteins) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Proteins) promoter and its activity.
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta (show PRKCZ Proteins) pathways in poly(I:C)-stimulated cells underlies Sp1 phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
The Genomic Context and Corecruitment of SP1 Affect ERRalpha Coactivation by PGC-1alpha in Muscle Cells
These results suggest that Sp1 regulates gene expression of AACS (show AACS Proteins) in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.
the results obtained in this study show that Znf179 (show RNF112 Proteins) autoregulation through Sp1-dependent mechanism plays an important role in neuroprotection, and NGF (show NGFB Proteins)-induced Sp1 signaling may help attenuate more extensive (ROS (show ROS1 Proteins)-induced) damage following brain injury
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (show NFATC1 Proteins) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (show MLXIP Proteins)-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (show SIRT1 Proteins) signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes
adrenergic stimulation induced complex formation between Ifrd1 (show IFRD1 Proteins), Sp1 and mSIN3B, which is a component of the SIN (show POLR3E Proteins) complex containing histone deacetylase (show HDAC1 Proteins), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (show IFRD1 Proteins) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Dp71 (show DMD Proteins) expression in hepatic cells is carried out, in part, by YY1 (show YY1 Proteins)-, Sp1- and Sp3-mediated transcription from the Dp71 (show DMD Proteins) promoter.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1