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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 and sod1 (show SOD1 Proteins) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
our study demonstrates that Sp1 is a major regulator in SRY (show SRY Proteins) gene transcription, and mutations of the Sp1 binding sites (Sp1-B and Sp1-C) in the 5' flanking region of SRY (show SRY Proteins) induce sex reversal in rabbits
The mechanism of prostaglandin E2-induced transcriptional up-regulation of Oncostatin-M (show OSM Proteins) by CREB (show CREB1 Proteins) and Sp1 (show PSG1 Proteins) has been described.
Results indicated that SP1dependent promoter elements drive FoxO3a (show FOXO3 Proteins) gene transcription in colorectal cancer (CRC (show CALR Proteins)), and indicated that SP1 (show PSG1 Proteins) upregulated FoxO3a (show FOXO3 Proteins) is critical for CRC (show CALR Proteins) progression.
Sp1 constitutively regulates the basal expression of the COMMD1 gene in human epithelial cell lines.
In the present study, specificity protein 1 (SP1) was demonstrated to be a direct target of miR (show MLXIP Proteins)-376a.
Results demonstrated that the upregulation of SP1 (show PSG1 Proteins) enhanced expression of VEGF (show VEGFA Proteins) promoting the angiogenesis and migration of trastuzumab-resistant ovarian cancer cell line SKOV3-T.
Data suggest that MIR129 or MIR335 overexpression in keratinocytes inhibits MMP9 (show MMP9 Proteins) promoter activity and protein expression by targeting SP1 (show PSG1 Proteins); inhibition of these microRNAs has the opposite effect. These mechanisms may be involved in regulation of wound healing. (MIR (show MLXIP Proteins) = microRNA; MMP9 (show MMP9 Proteins) = matrix metalloproteinase-9 (show MMP9 Proteins); SP1 (show PSG1 Proteins) = transcription factor-SP1)
The possible involvement of the GC box 1 at position - 54 in transcriptional regulation of Rbpms (show RBPMS Proteins) was corroborated by EMSA, which showed formation of a DNA-protein complex in the presence of the oligonucleotide corresponding to this Sp1 (show PSG1 Proteins)-binding site.
Our results suggested that BetA was able to enhance radiosensitization at least partially by downregulating Sp1 (show PSG1 Proteins) and upregulating PTEN through inducing Sp1 (show PSG1 Proteins) sumoylation. BetA is suggested to be a promising drug for increasing radiosensitization in oral squamous cell carcinoma radiotherapy.
Mutation of two Sp1 (show PSG1 Proteins) motifs strongly reduced trans-activation of the late UF1 promoter by HPyV9 large T-antigen in HeLa cells.
RhoGDIbeta overexpression led to downregulation of miR (show MLXIP Proteins)-200c, whereas miR (show MLXIP Proteins)-200c was able directly to target 3'-UTR of jnk2mRNA and attenuated JNK2 (show MAPK9 Proteins) protein translation, which resulted in attenuation of Sp1mRNA and protein expression in turn, inhibiting Sp1 (show PSG1 Proteins)-dependent MMP-2 (show MMP2 Proteins) transcription.
study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG (show PPARG Proteins) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH Proteins) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP Proteins) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Proteins) promoter and its activity.
Sp-1 negatively regulates the expression of miR (show MLXIP Proteins)-20b in macrophages.
an immunoprecipitation assay indicated that hypoxia triggered activation of the binding activity of Sp1 to the promoters of PARP-1 (show PARP1 Proteins) and caspase-3 (show CASP3 Proteins), which is abrogated by miR (show MLXIP Proteins)-7a/b. In summary, these findings identified miR (show MLXIP Proteins)-7a/b as protectors of cardiac remodeling and hypoxia-induced injury in H9c2 cardiomyoblasts involving Sp1 and PARP-1 (show PARP1 Proteins).
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta (show PRKCZ Proteins) pathways in poly(I:C)-stimulated cells underlies Sp1 phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
The Genomic Context and Corecruitment of SP1 Affect ERRalpha Coactivation by PGC-1alpha in Muscle Cells
These results suggest that Sp1 regulates gene expression of AACS (show AACS Proteins) in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.
the results obtained in this study show that Znf179 (show RNF112 Proteins) autoregulation through Sp1-dependent mechanism plays an important role in neuroprotection, and NGF (show NGFB Proteins)-induced Sp1 signaling may help attenuate more extensive (ROS (show ROS1 Proteins)-induced) damage following brain injury
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (show NFATC1 Proteins) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (show MLXIP Proteins)-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (show SIRT1 Proteins) signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1