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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 and sod1 (show SOD1 Proteins) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
MBD1 (show DPEP1 Proteins) may be a tumor suppressor gene in advanced colorectal cancer (CRC (show CALR Proteins))and affect the development and metastasis of CRC (show CALR Proteins) by regulating 8 tumor suppressor genes through binding with SP1 (show PSG1 Proteins).
our results demonstrate that Sp1 (show PSG1 Proteins) positively regulates the basal transcription of FGF21 (show FGF21 Proteins) in the liver and adipose tissue and contributes to the obesity-induced FGF21 (show FGF21 Proteins) upregulation in mouse adipose tissue and hepatic FGF21 (show FGF21 Proteins) upregulation in hepatocarcinogenesis.
The variant lies in a novel binding-site for the transcription factor Sp1, known to be involved in the regulation of ENG (show ENG Proteins) and ACVRL1 (show ACVRL1 Proteins) transcription.
The results suggest that PLY inhibits osteoblast differentiation by downregulation of Sp1 (show PSG1 Proteins) accompanied by induction of autophagy through ROS (show ROS1 Proteins)-mediated regulation of the AMPK (show PRKAA1 Proteins)/mTOR (show FRAP1 Proteins) pathway.
these findings demonstrate that p53 (show TP53 Proteins) can repress MCAK (show KIF2C Proteins) promoter activity indirectly via down-regulation of Sp1 (show PSG1 Proteins) expression level, and suggest that MCAK (show KIF2C Proteins) elevation in human tumor cells might be due to p53 (show TP53 Proteins) mutation
Our study provides new evidence that interaction of KLF6 and Sp1 regulates basigin-2 expression in hepatocellular carcinoma
Our study showed there was a positive correlation between Sp1 (show PSG1 Proteins) and COX2 expression in pancreatic ductal adenocarcinoma
Data indicate the Sp1 (show PSG1 Proteins) oncogene (show RAB1A Proteins) functions as a positive regulator for BCR/ABL (show ABL1 Proteins) expression.
This result indicates that the formation of copper-finger protein of Sp1 (show PSG1 Proteins) is the molecular basis of copper sensing for the transcriptional regulation of hCtr1 (show SLC31A1 Proteins) in mammalian cells.
Data show that SOX9 (show SOX9 Proteins) regulates CEACAM1 (show CEACAM1 Proteins) primarily via Sp1 (show PSG1 Proteins) and ETS1 (show ETS1 Proteins).
study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG (show PPARG Proteins) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH Proteins) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP Proteins) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Proteins) promoter and its activity.
The Genomic Context and Corecruitment of SP1 Affect ERRalpha Coactivation by PGC-1alpha in Muscle Cells
These results suggest that Sp1 regulates gene expression of AACS (show AACS Proteins) in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.
the results obtained in this study show that Znf179 (show RNF112 Proteins) autoregulation through Sp1-dependent mechanism plays an important role in neuroprotection, and NGF (show NGFB Proteins)-induced Sp1 signaling may help attenuate more extensive (ROS (show ROS1 Proteins)-induced) damage following brain injury
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (show NFATC1 Proteins) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (show MLXIP Proteins)-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (show SIRT1 Proteins) signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes
adrenergic stimulation induced complex formation between Ifrd1 (show IFRD1 Proteins), Sp1 and mSIN3B, which is a component of the SIN (show POLR3E Proteins) complex containing histone deacetylase (show HDAC1 Proteins), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (show IFRD1 Proteins) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Dp71 (show DMD Proteins) expression in hepatic cells is carried out, in part, by YY1 (show YY1 Proteins)-, Sp1- and Sp3-mediated transcription from the Dp71 (show DMD Proteins) promoter.
SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1