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Cdon is required to localize N-cadherin (show CDH2 Proteins) to the cell membrane in migratory neural crest cells for directed migration.
In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog (show SHH Proteins) protein, thereby limiting its dispersion.
We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis
CDO (show CDO1 Proteins) is required for proliferation and survival of lung cancer cells via Hh signaling.
These data support the view that cell-adhesion molecule (show MCAM Proteins)-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer.
Mutations in the CDON cause holoprosencephaly. (Review)
We found that CDON is overexpressed in prostate cancer
CDON must associate with both ligand and other hedgehog (show SHH Proteins)-receptor components, particularly PTCH1 (show PTCH1 Proteins), for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly.
Hedgehog (show SHH Proteins) proteins interact with cell adhesion molecule (show MCAM Proteins), down-regulated by oncogenes (CDO (show CDO1 Proteins)) and brother of CDO (BOC (show BOC Proteins)) in a conserved manner
CDO (show CDO1 Proteins) and BOC (show BOC Proteins) play a role in differentiation of cells in the skeletal muscle lineage
CDO (show CDO1 Proteins) and BOC (show BOC Proteins) forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact.
These results support a model whereby mutations in Cdon and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh (show SHH Proteins) signaling activity.
Mutation in the Cdon gene is associated with congenital nevus development.
Study assessed the role of the Shh (show SHH Proteins) receptor Cdon in the development of ventral tegmental area and substantia nigra pars (show EPRS Proteins) compacta dopamine neurons. Results suggest that Cdon plays an important role in the encoding of diversity within the population of dopamine neurons of the midbrain, influencing both the development of the mesocortical dopamine pathway as well as behavioral outputs that involve this neural circuitry.
Results suggest that a promyogenic cell adhesion molecule (show MCAM Proteins) Cdo (show CDO1 Proteins) signaling is critical for Inward rectifier potassium channel Kir2.1 (show KCNJ2 Proteins) activities in the induction of myogenic differentiation.
PKN2 (show PKN2 Proteins) formed complexes with Cdo (show CDO1 Proteins), APPL1 (show APPL1 Proteins) and AKT (show AKT1 Proteins) via its C-terminal region and this interaction appeared to be important for induction of AKT (show AKT1 Proteins) activity as well as myoblast differentiation.
that Cdon participates in oligodendrocyte differentiation and myelination, most likely in the initial stages of development
Suggest that Cdo (show CDO1 Proteins) is required for the full Shh (show SHH Proteins) signaling activation to induce efficient dopaminergic neuron neurogenesis.
Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1 (show PTCH1 Proteins).
Cx43 (show GJA1 Proteins) physically interacts with Cdo (show CDO1 Proteins) to form dynamic complexes during myoblast differentiation
Stim1 (show STIM1 Proteins) protein levels were decreased in Cdo (show CDO1 Proteins)-deficient perinatal hindlimb muscles or primary myoblasts; this correlates with defective NFATc3 (show NFATC3 Proteins) activation in Cdo (show CDO1 Proteins)(-/-) myoblasts upon differentiation.
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
Cdon homolog (mouse)
, surface glycoprotein, Ig superfamily member
, cell adhesion molecule-related/down-regulated by oncogenes
, Cdon homolog
, immunoglobulin superfamily member
, CAM-related/down-regulated by oncogenes
, immunoglobulin superfamily member CDO
, oncogene-regulated cell adhesion molecule
, cysteine dioxygenase type 1
, cysteine dioxygenase type I