CDON Protein (His tag)

Catalog No. ABIN7319654

Product Details

Target: CDON (Cell Adhesion Molecule-Related/down-Regulated By Oncogenes (CDON))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This CDON protein is labelled with His tag.

Purpose: Recombinant Human CDO/CDON Protein (His Tag)

Sequence: Asp26-Pro943

Characteristics: Recombinant Human CDO is produced by our Mammalian expression system and the target gene encoding Asp26-Pro943 is expressed with a 6His tag at the C-terminus.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CDON (Cell Adhesion Molecule-Related/down-Regulated By Oncogenes (CDON))

Alternative Name: CDO/CDON (CDON Products)

Synonyms: CDO Protein, CDON1 Protein, HPE11 Protein, ORCAM Protein, Cdo Protein, Cd0 Protein, Orcam Protein, cb507 Protein, wu:fa10c03 Protein, wu:fb94b11 Protein, zgc:158240 Protein, cdon-A Protein, cell adhesion associated, oncogene regulated Protein, cell adhesion molecule-related/down-regulated by oncogenes Protein, cell adhesion associated, oncogene regulated L homeolog Protein, CDON Protein, Cdon Protein, cdon Protein, cdon.L Protein

Background:

Background: CDO (CAMrelated/down-regulatedby oncogenes) is a member of the Immunoglubulin (Ig) superfamily, Ig/Fibronectin (FN)type III repeat family of cell surface proteins. Human CDO is a type I transmembrane (TM) glycoprotein. It is synthesized as a 1287 amino acid (aa) precursorthat contains a 25 aa signal sequence, a 938 aa extracellular domain (ECD), a 21 aa TM segment and a 303 aa cytoplasmic region. The ECD contains five C2-typeIglikedomains, followed by three FN type III repeats. The ECD of human CDO is 85 % aa identical to mouse CDO ECD.CDO is found on muscle precursor and neural progenitor cells of the embryo. It likely promotes muscle differentiation, and contributes to axon guidance andneuronal patterning.

Synonym: Cell adhesion molecule-related/down-regulated by oncogenes, CDON, CDO

Molecular Weight: 100.4 kDa

UniProt: Q4KMG0

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Embryonic Body Morphogenesis