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Browse our anti-FDPS (FDPS) Antibodies

Full name:: anti-Farnesyl Diphosphate Synthase Antibodies (FDPS)

On www.antibodies-online.com are 116 Farnesyl Diphosphate Synthase (FDPS) Antibodies from 23 different suppliers available. Additionally we are shipping FDPS Kits (17) and FDPS Proteins (13) and many more products for this protein. A total of 152 FDPS products are currently listed.

Synonyms:: (2E, 16.m00760, 6030492I17Rik, Ac2-125, AI256750, CG12389, DDBDRAFT_0206220, DDBDRAFT_0215017, DDB_0206220, DDB_0215017, Dmel\\CG12389, DmFPPS, DmFPPSase, DmFPS, Fdpsl1, FPPS, fps, l(2)k06103, mKIAA1293, NCU01175.1, v(2)k03514

list all antibodies	Gene Name	GeneID	UniProt
	FDPS	2224	P14324
	FDPS	83791	P05369
	FDPS	110196	Q920E5
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Most Popular Reactivities for anti-FDPS (FDPS) Antibodies

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anti-Human FDPS Antibodies:

anti-Rat (Rattus) FDPS Antibodies:

anti-Mouse (Murine) FDPS Antibodies:

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Relevant Pathways for anti-FDPS Antibodies

Regulation of Muscle Cell Differentiation

More product categories related to FDPS Antibody

Top referenced anti-FDPS Antibodies

Human Polyclonal FDPS Primary Antibody for IHC (p), WB - ABIN389054 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
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Human Polyclonal FDPS Primary Antibody for IF, IHC (p) - ABIN1882080 : Nomura, Miyajima, Sazuka, Tanaka, Kawarabayasi, Sato, Nagase, Seki, Ishikawa, Tabata et al.: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature ... in DNA research : an international journal for rapid publication of reports on genes and genomes 1995 (PubMed)
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Human Polyclonal FDPS Primary Antibody for IHC (p), ELISA - ABIN545249 : Wilkin, Kutsunai, Edwards et al.: Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, ... in The Journal of biological chemistry 1990 (PubMed)
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More Antibodies against FDPS Interaction Partners

Fruit Fly (Drosophila melanogaster) Farnesyl Diphosphate Synthase (FDPS) interaction partners

mitochondrial targeting of FPS may be widespread among eukaryotes
Farnesyl diphosphate synthase (FPPS) of the dipteran Drosophila melanogaster has been cloned and its catalytic properties have been assessed.

Human Farnesyl Diphosphate Synthase (FDPS) interaction partners

Farnesyl pyrophosphate (FPP) allosterically regulated the activity of farnesyl pyrophosphate synthase.
FPPS mediates TGF-beta1-induced lung cancer cell invasion and epithelial-to-mesenchymal transition via the RhoA/Rock1 pathway.
Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase
These results are consistent with the previously proposed hypothesis that the allosteric pocket of human FPPS, located near the active site, plays a feed-back regulatory role for this enzyme.
our study indicated that DR patients have higher VEGF levels than diabetic patients without retinopathy, and -2578A/C (rs699947) and +405C/G (rs2010963) may be important factors in determining serum VEGF levels.
Results suggest that polymorphisms of the FDPS gene may influence the bone response to drugs targeting the mevalonate pathway, like statins.
A co-crystal structure of human farnesyl pyrophosphate synthase in complex with a bisphosphonate and two molecules of inorganic phosphate.
The results identify new classes of FPPS inhibitors, diterpenoids and sesquiterpenoids, that bind to the IPP site and may be of interest as anticancer and antiinfective drug leads.
These observations suggest that an increase in the expression of endogenous FPPS could confer at least partial resistance to the pharmacological effect of N-BP drugs such as ZOL in vivo
LRP5 and FDPS loci age-specifically affect skeletal traits in healthy fertile women.
Data indicate compounds represent a new structural class of farnesyl pyrophosphate synthase (hFPPS) inhibitors and suggest a development of therapeutics.
The iPA-driven modulation of FDPS can cause an enhancement of post-translational prenylation essential for the biological activity of key proteins in NK signaling and effector functions, such as Ras.
FPPS was more highly expressed in prostate cancer vs. normal prostate tissue. The association of FPPS with established histopathological risk parameters and biochemical recurrence implicates a contribution of the mevalonate pathway to PC progression.
FPPS might play an important role in Ang II-induced cardiac hypertrophy and fibrosis in vivo, at least in part through RhoA, p-38 MAPK and TGF-beta1.
The crystal structure of human FPPS in complex with a novel bisphosphonate YS0470 and in the absence of a second substrate showed partial ordering of the tail in the closed conformation.
Common polymorphisms of the FDPS gene influence the response to bisphosphonates in osteoporotic women.
findings reveal a FDPS-dependent mechanism in the internalization and down-regulation of beta2AR, identify FDPS as a potential target for improving the therapeutic efficacy of beta-agonists
first study on the gene FDPS rs2297480 SNP in postmenopausal Thai women.The effect did not contribute to the baseline of bone mineral density nor bone turnover markers.
The A/C rs2297480 polymorphism of FDPS was highly differently distributed among osteonecrosis-of-the-jaw patients and controls, with a correlation between AA carrier status and occurrence of ONJ after 18-24 months of treatment with bisphosphonates.
characterized the sterol-response-element-binding protein 2 and nuclear factor Y-binding site in the farnesyl diphosphate synthase promoter

Mouse (Murine) Farnesyl Diphosphate Synthase (FDPS) interaction partners

Overexpression of FPPS aggravates myocardial ischemia/reperfusion injury in mice.
Farnesyl pyrophosphate synthase (FPPS) may function as a potent regulator in myocardial remodelling. The FPPS-regulated signalling pathway is relevant to the pathological changes in cardiac hypertrophy and heart failure.
novel role in fibroblast growth factor-mediated signal transduction
identified a single putative direct repeat 4 (DR4) LXR response element in the FPS promoter isolated from immortalized murine astrocyte P11-5 cells

FDPS Antigen Profile

Antigen Summary

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FDPS

Farnesyl pyrophosphate synthase (Fpps) antibody
farnesyl diphosphate synthase (fdps) antibody
farnesyl diphosphate synthase L homeolog (fdps.L) antibody
farnesyl pyrophosphate synthase (MGG_08649) antibody
farnesyl pyrophosphate synthetase (TP03_0857) antibody
farnesyl pyrophosphate synthetase (Tb09.160.4300) antibody
farnesyl-pyrophosphate synthetase (fpp) antibody
farnesyl pyrophosphate synthetase (BBOV_I000120) antibody
FDP synthase (fps) antibody
Farnesyl pyrophosphate synthetase (fpps) antibody
farnesyl diphosphate synthase (FDPS) antibody
farnesyl diphosphate synthase (Fdps) antibody
farnesyl diphosphate synthetase (Fdps) antibody
farnesyl pyrophosphate synthase 1 (fps1) antibody

(2E antibody
16.m00760 antibody
6030492I17Rik antibody
Ac2-125 antibody
AI256750 antibody
CG12389 antibody
DDBDRAFT_0206220 antibody
DDBDRAFT_0215017 antibody
DDB_0206220 antibody
DDB_0215017 antibody
Dmel\\CG12389 antibody
DmFPPS antibody
DmFPPSase antibody
DmFPS antibody
Fdpsl1 antibody
FPPS antibody
fps antibody
l(2)k06103 antibody
mKIAA1293 antibody
NCU01175.1 antibody
v(2)k03514 antibody

Protein level used designations for FDPS

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , farnesyl pyrophosphate synthase CG12389-PA Fpps-PA farnesyl diphosphate synthase farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) farnesyl pyrophosphate synthetase Farnesyl pyrophosphate synthetase (2E,6E)-farnesyl diphosphate synthase FPP synthase FPP synthetase dimethylallyltranstransferase farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase geranyltranstransferase CR 39 cholesterol-regulated 39 kDa protein farnesyl diphosphate synthetase testis-specific farnesyl pyrophosphate synthetase FPS 6E)-farnesyl diphosphate synthase FPPS GRMZM2G168681 PCO074380 PCO074380(592) PCO074380_ov PCO074380b QBB18h08 geranylgeranyl-diphosphate synthase gnp_QBB18h08b gpm430b prenyltransferase

GENE ID	SPECIES
36209	Drosophila melanogaster
548584	Xenopus (Silurana) tropicalis
735190	Xenopus laevis
2678891	Magnaporthe oryzae 70-15
3499793	Theileria parva strain Muguga
3660082	Trypanosoma brucei brucei strain 927/4 GUTat10.1
3877737	Neurospora crassa OR74A
5476865	Babesia bovis T2Bo
8621722	Dictyostelium discoideum AX4
100195349	Salmo salar
2224	Homo sapiens
83791	Rattus norvegicus
281156	Bos taurus
480129	Canis lupus familiaris
425061	Gallus gallus
110196	Mus musculus
541903	Zea mays

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Show all anti-Farnesyl Diphosphate Synthase (FDPS) Antibodies with Pubmed References