FDPS antibody (N-Term)

Catalog No. ABIN1882080

Cited in 2+ publications. The Rabbit Polyclonal anti-FDPS antibody (Clone RB4783-4784) (ABIN1882080) specifically detects FDPS in WB, IHC (p) and IF. The antibody is reactive with Human samples.

Quick Overview for FDPS antibody (N-Term) (ABIN1882080)

Target: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FDPS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: RB4783-4784

Product Details anti-FDPS Antibody

Binding Specificity: AA 82-112, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-112 amino acids from the N-terminal region of human FDPS.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:100. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-FDPS antibody (ABIN1882080)

Wilkin, Kutsunai, Edwards et al.: "Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, ..." in: The Journal of biological chemistry, Vol. 265, Issue 8, pp. 4607-14, (1990) (PubMed).

Sheares, White, Molowa, Chan, Ding, Kroon, Bostedor, Karkas: "Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells." in: Biochemistry, Vol. 28, Issue 20, pp. 8129-35, (1990) (PubMed).

Target Details for FDPS

Target: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Alternative Name: FDPS

Background: The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.

Molecular Weight: 48275

NCBI Accession: NP_001129293, NP_001129294, NP_001229753, NP_001229754, NP_001995

UniProt: P14324

Pathways: Regulation of Muscle Cell Differentiation