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anti-Human HEY2 Antibodies:
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Zebrafish (Danio rerio) Polyclonal HEY2 Primary Antibody for WB - ABIN1881411
Winkler, Elmasri, Klamt, Volff, Gessler: Characterization of hey bHLH genes in teleost fish. in Development genes and evolution 2003
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Cow (Bovine) Polyclonal HEY2 Primary Antibody for ELISA - ABIN4317227
Tang, Urs, Liaw: Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. in Circulation research 2008
HEY2 as a promising biomarker for unfavorable outcomes and a novel therapeutic target for the clinical management of HCC (show FAM126A Antibodies)
Genetic variation of HEY2 is associated with Brugada syndrome through alteration of ion channel expression in the cardiac ventricular wall.
Individuals with HEY2 duplications should be screened for congenital heart defects.
HEY2 CC genotype may be a favorable prognostic marker for BrS, protectively acting to prevent ventricular fibrillation presumably by regulating the repolarization current.
Overexpression of HEY1 (show HEY1 Antibodies) and HEY2 in esophageal squamous cell carcinoma (ESCC) is correlated to different indices of poor prognosis, and it is extrapolated that such overexpression is important in progression and development of ESCC tumorigenesis.
bone morphogenic proteins within the serum of cell culture medium are potent inducers of endothelial Hey1 (show HEY1 Antibodies) and Hey2 gene expression within the first few hours after medium change
a new HRD1 (show SYVN1 Antibodies)-associated membrane protein named HERP2 (show HEY1 Antibodies), which is homologous to the previously identified HRD1 (show SYVN1 Antibodies) partner HERP1. Despite sequence homology, HERP2 (show HEY1 Antibodies) is constitutively expressed in cells, whereas HERP1 is highly induced by ER stress.
Data indicate that culture abrogated differential gene expression in part due to gradual loss of canonical Notch (show NOTCH1 Antibodies) activity and HEY2 expression.
Common variants at SCN5A (show SCN5A Antibodies)-SCN10A (show SCN10A Antibodies) and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Hey2 and COUP-TFII (show NR2F2 Antibodies) have an important role in arteriovenous differentiation of human endothelial cells.
Data implied that Hey2 function is restricted to transient amplifying cells of the ameloblast cell lineage and that Hey1 (show HEY1 Antibodies) plays a role in the composition of the subodontoblastic layer, in addition to ameloblast differentiation.
Hey proteins mechanistically repress target genes via histone deacetylase (show HDAC1 Antibodies) recruitment and histone deacetylation.
Results suggest that bone morphogenetic protein signaling plays pivotal roles in retinal progenitor cell differentiation into late differentiating retinal cell types and in Muller glia maturation; these effects were mediated, at least in part, by Hey2
Hey1 (show HEY1 Antibodies) and Hey2 in endothelial cells play important roles in vascular development.
findings indicate that Hey1 (show HEY1 Antibodies) and Hey2 control the spatial and temporal pattern of auditory HC differentiation.
CHF1/Hey2 may contribute to Brugada syndrome.
Common variants at SCN5A (show SCN5A Antibodies)-SCN10A (show SCN10A Antibodies) and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
Data indicate that Hairy and Enhancer of Split-related with YRPW motif (HEY)2 decreases skeletal mass and regulates bone remodeling in male mice.
Data indicate that Notch1 (show NOTCH1 Antibodies) and Notch2 (show NOTCH2 Antibodies) are expressed and localized in the nuclei of the label-retaining cells (LRCs), and the expression of Notch (show NOTCH1 Antibodies)-inducible genes, Hes1 (show HES1 Antibodies) and Hey2, was elevated in LRCs.
Survivor mice lacking the Hesr2 gene exhibit fibrosis in the aortic valve and ventricle in adulthood, thus suggesting that Hesr2 plays an important role in maintaining the homeostasis of the aortic valve and ventricle.
essential role for Hey2 upstream of Notch in hematopoietic stem cell formation
Forms a complex with Gata5 through the carboxyl region and can repress Gata5-mediated transcription.
The snrk (show SNRK Antibodies)-1 gene acts downstream or parallel to notch (show NOTCH1 Antibodies) and upstream of gridlock during artery-vein specification
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
hairy/enhancer-of-split related with YRPW motif protein 2
, HES-related repressor protein 1
, HES-related repressor protein 2
, cardiovascular basic helix-loop-helix factor 1
, cardiovascular helix-loop-helix factor 1
, class B basic helix-loop-helix protein 32
, hairy and enhancer of split-related protein 2
, hairy-related transcription factor 2
, protein gridlock homolog
, Hairy-E(spl)-related with YRPW motif 2
, hairy and enhancer of split related 2
, protein gridlock