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HEY2 Products

(Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2))

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This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].

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Featured HEY2 Categories

HEY2 Antibodies

High quality antibodies with extensive validation data.

HEY2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HEY2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (3)
Cat. No. ABIN652095
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF, ICC
Validations
  • (2)
Cat. No. ABIN6262369
Quantity 100 μL
Datasheet Datasheet
Reactivity Zebrafish (Danio rerio)
Application WB
Validations
  • (3)
  • (1)
Cat. No. ABIN1881411
Quantity 400 μL
Datasheet Datasheet

Recommended HEY2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3137357
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3081431
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1306572
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our HEY2 products

Tang, Urs, Liaw: "Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site." in: Circulation research, Vol. 102, Issue 6, pp. 661-8, (2008) (PubMed).

Winkler, Elmasri, Klamt, Volff, Gessler: "Characterization of hey bHLH genes in teleost fish." in: Development genes and evolution, Vol. 213, Issue 11, pp. 541-53, (2003) (PubMed).

Zhong, Childs, Leu, Fishman: "Gridlock signalling pathway fashions the first embryonic artery." in: Nature, Vol. 414, Issue 6860, pp. 216-20, (2001) (PubMed).

Zhong, Rosenberg, Mohideen, Weinstein, Fishman: "gridlock, an HLH gene required for assembly of the aorta in zebrafish." in: Science (New York, N.Y.), Vol. 287, Issue 5459, pp. 1820-4, (2000) (PubMed).

Synonyms and alternative names related to HEY2

hes related family bHLH transcription factor with YRPW motif 2 (HEY2), hairy/enhancer-of-split related with YRPW motif 2 (Hey2), hes-related family bHLH transcription factor with YRPW motif 2 (hey2), hes-related family bHLH transcription factor with YRPW motif 2 (Hey2), bHLHb32, CHF1, GRIDLOCK, GRL, grl, HERP1, Herp1, HESR2, hesr2, HRT2, Hrt2, zgc:136746

Protein level used designations for HEY2

  • hairy/enhancer-of-split related with YRPW motif protein 2
  • HES-related repressor protein 1
  • HES-related repressor protein 2
  • HESR-2
  • HRT-2
  • cardiovascular basic helix-loop-helix factor 1
  • cardiovascular helix-loop-helix factor 1
  • class B basic helix-loop-helix protein 32
  • hCHF1
  • hHRT2
  • hairy and enhancer of split-related protein 2
  • hairy-related transcription factor 2
  • protein gridlock homolog
  • Hairy-E(spl)-related with YRPW motif 2
  • hairy and enhancer of split related 2
  • mHRT2
  • Herp2
  • gridlock
  • protein gridlock
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