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anti-Rat (Rattus) PTBP1 Antibodies:
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Human Polyclonal PTBP1 Primary Antibody for WB - ABIN1881702
Osada, Uno, Mineta, Kameoka, Takahashi, Terao: Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta. in Molecular ecology 2010
Show all 5 Pubmed References
Human Polyclonal PTBP1 Primary Antibody for IHC (p), IHC - ABIN250017
Cote, Zhu, Thomas, Martin, Murad, Sharina: Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells. in PLoS ONE 2012
Show all 2 Pubmed References
Cow (Bovine) Polyclonal PTBP1 Primary Antibody for WB - ABIN2778815
Somberg, Zhao, Fröhlich, Evander, Schwartz: Polypyrimidine tract binding protein induces human papillomavirus type 16 late gene expression by interfering with splicing inhibitory elements at the major late 5' splice site, SD3632. in Journal of virology 2008
Show all 2 Pubmed References
inactivation of both exosc9, which encodes a component of the RNA exosome, and ptbp1, which encodes an RNA-binding protein abundant in Xenopus embryonic skin, impairs embryonic Xenopus skin development.
Polypyrimidine tract binding protein prevents activity of an intronic regulatory element that promotes usage of a composite 3'-terminal exon
PTBP1 is a novel regulator of MCL1 (show MCL1 Antibodies) mRNA by which it controls apoptotic response to antitubulin chemotherapeutics.
PTB interacts specifically with 3'UTR (show UTS2R Antibodies) of p53 (show TP53 Antibodies) mRNA and positively regulates expression of p53 (show TP53 Antibodies) isoforms. PTB showed some overlapping binding regions in the p53 (show TP53 Antibodies) 3'UTR (show UTS2R Antibodies) with miR (show MLXIP Antibodies)-1285. Knockdown of miR (show MLXIP Antibodies)-1285 as well as expression of p53 (show TP53 Antibodies) 3'UTR (show UTS2R Antibodies) with mutated miR (show MLXIP Antibodies)-1285 binding sites resulted in enhanced association of PTB with the 3'UTR (show UTS2R Antibodies), which provides mechanistic insights of this interplay.
It has been established that PTBP1 and PTBP2 (show PTBP2 Antibodies) are members of a family of cryptic exon repressors.
These results demonstrate that during early stages of splicing, exon RNP (show RNPC3 Antibodies) complexes are highly dynamic with many proteins failing to bind during PTBP1 arrest.
Studied interactions of polypyrimidine tract-binding protein (PTBP1), pyruvate kinase M2 (PKM2), and STAT3 (signal transducer and activator of transcription 3 (show STAT3 Antibodies)) in oncogenesis of anaplastic large cell lymphoma (ALCL). Results show that in ALCL cells, PTBP1 is crucial for PKM2 phosphorylation of STAT3 (show STAT3 Antibodies) in the nucleus.
Expression of ATG10 (show ATG10 Antibodies) negatively regulated by PTBP1 and is associated with metastasis of colorectal cancer cells.
Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm.
follow-up molecular analyses of one splicing factor (show SLU7 Antibodies) PTBP1 revealed its impact on disease-associated splicing patterns in Huntington's disease (HD). Collectively, our data provide genomic evidence for widespread splicing dysregulation in HD brains, and suggest the role of aberrant alternative splicing in the pathogenesis of HD
CD5 (show CD5 Antibodies) transcription is increased, leading to the production of three mRNA isoforms by APA (show ENPEP Antibodies), all contributing for protein production, at different levels. PTBP1 binds in the vicinity of pA1 (show PAGR1 Antibodies), leading to an increase in mRNA levels and miR (show MLXIP Antibodies)-204 targets the longer CD5 (show CD5 Antibodies) mRNA.
Increased expression of microRNA miR (show MLXIP Antibodies)-145 combined with knockdown of PTBP1 protein contributed to the greater and longer growth suppression compared with each single treatment.
In round spermatids, MRG15 (show MORF4L1 Antibodies) colocalizes with splicing factors PTBP1 and PTBP2 (show PTBP2 Antibodies) at H3K36me3 sites between the exons and single intron of transition nuclear protein 2 (Tnp2 (show TNP2 Antibodies)). Thus, our results reveal that MRG15 (show MORF4L1 Antibodies) is essential for pre-mRNA splicing during spermatogenesis and that epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorder
This knockin Ptbp1 rescued a forebrain-specific, but not a pan (show SUPT6H Antibodies)-neuronal, Ptbp2 (show PTBP2 Antibodies) knockout, demonstrating both redundant and distinct roles for the proteins. Many developmentally regulated exons exhibited different sensitivities to PTBP1 and PTBP2 (show PTBP2 Antibodies).
Results indicate that heterogeneous nuclear ribonucleoprotein I (hnRNPI) plays a critical role in establishing neonatal immune adaptation and preventing colitis and colorectal cancer.
Thus, PTBP1 controls the activity of Pbx1 (show PBX1 Antibodies) to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.
showed polypyrimidine tract binding protein (PTBP)-dependent alternative splicing of CaMKIIalpha (show CAMK2 Antibodies) transcripts in the lens
This may account for the tight correlation between Hps1 with Ptbp1 expression levels observed across mammalian tissues.
The expression levels of three splicing factors, ESRP1 (show ESRP1 Antibodies), PTB and SF2/ASF (show SRSF1 Antibodies), are significantly altered during cardiac hypertrophy in mice.
Study reports that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR (show MLXIP Antibodies)-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons.
The polypyrimidine tract binding proteins PTBP1 and PTBP2 (show PTBP2 Antibodies) repressed Psd-95 (show DLG4 Antibodies) (also known as Dlg4 (show DLG4 Antibodies)) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay.
PTBP1 is not required for the earliest isovolumetric divisions and differentiation steps of the zygote up to the formation of the blastocyst.
Data report on a zebrafish maternal-effect (show NLRP5 Antibodies) mutant, brom bones, which is defective in the cytosolic Ca(2 (show CA2 Antibodies)+) rise and subsequent egg activation events, including cortical granule exocytosis and cytoplasmic segregation [brom bones].
Two stretches of polypyrimidine tracts designated PPT1 and PPT2 which influence the IRES activity of cx55.5 protein were identified; deletion of PPT1 results in an appreciable decrease of the IRES activity
PTB1 is a splicing factor (show SLU7 Antibodies) that influences alternative splicing and acts at the polypyrimidine tract.
Alternative splicing (AS) patterns as well as the expression of key flowering regulators were massively changed in a PTB1/2 level-dependent manner.
AtPTB1 and AtPTB2 are widely expressed in almost all tissues, with the highest expression levels in late-maturing and mature pollen grains, and are crucial for pollen germination. [AtPTB1]
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
polypyrimidine tract binding protein 1
, hnrnp I
, hnRNP I-related RNA transport protein VgRBP60
, polypyrimidine tract-binding protein
, polypyrimidine tract-binding protein 1
, 57 kDa RNA-binding protein PPTB-1
, RNA-binding protein
, heterogeneous nuclear ribonucleoprotein I
, heterogeneous nuclear ribonucleoprotein polypeptide I
, hnRNP I
, polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
, pyrimidine binding protein 1
, pyrimidine binding protein 2
, brom bones