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anti-Human SIX4 Antibodies:
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Human Monoclonal SIX4 Primary Antibody for IF, ELISA - ABIN565685
Qamar, Deitsch, Patrick, Post, Spillman, Iwanaga, Thorburn, Ford, Behbakht: Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer. in Gynecologic oncology 2012
SIX4 and SIX6 were linked to the lymph node metastasis in NSCLC.
significant co-localization of binding sites for MyoD and Six proteins on over a thousand mouse genomic DNA regions, were found.
The results indicated that low Six4 and Six5 gene dosage improved dystrophic phenotypes of Dmd(mdx) /Y mice by enhancing muscle regeneration, and suggested that SIX4 and SIX5 are potentially useful de novo targets in therapeutic applications against muscle disorders, including DMD.
data support a model where Eya-Six may form a complex to regulate nephron progenitor cell development before metanephric specification and are critical mesenchymal factors for inducing nephric duct development.
results reveal a role for Six4 during adult muscle regeneration and suggest a widespread mechanism of cooperation between Six4 and MyoD.
the transcription factors Six1 and Six4 are required for male gonadal differentiation.
Direct molecular regulation of the myogenic determination gene Myf5 by Pax3, with modulation by Six1/4 factors, is exemplified by the -111 kb-Myf5 enhancer
Data show that absence of Six1 and Six4 leads to the development of dorsal myofibers lacking expression of fast-type muscle genes, and mainly expressing a slow-type muscle program.
These results suggest that Six1 and Six4 genes are expressed in the taste bud cells, in newly formed or surviving type-II cells.
Six4 and Six5 repressed, while Six1 activated myogenin expression, suggesting that the differential regulation of myogenin expression is responsible for the differential effects of Six genes
Six1 and Six4 expression is required to specifically activate fast-type muscle genes
Data show that Six4 is transcriptional regulatory element X (TrexBF) in skeletal myocytes and transactivates the muscle creatine kinase enhancer.
Early syndetomal expression of scleraxis is reduced in the Six1Six4 embryo
Six1 and Six4 regulate Slc12a2, the promoter region of Slc12a2 contains multiple Six1-binding sites and one common binding site of Six1 and Six4
essential role for Eya1 and Six genes in patterning the third pouch into organ-specific primordia
Six1 and Six4 have collaborative functions in the metanephros but not in the mesonephros.
Six4 is involved in myogenic regulatory gene Myf5 expression in the developing limb.
The threshold of Six1/4 may be crucial for the expression of olfactory specific genes and Six1 and Six4 may act synergistically to mediate olfactory placode specification and patterning through Fgf and Bmp signaling pathways.
This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells.
homeobox protein SIX4
, sine oculis homeobox homolog 4
, sine oculis-related homeobox 4 homolog
, skeletal muscle-specific ARE-binding protein AREC3
, sine oculis homeobox homolog 4.2
, sine oculis homeobox homolog 4a
, sine oculis homeobox homolog 4b