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Human Monoclonal TNC Primary Antibody for CyTOF, ELISA - ABIN259023
Tsunoda, Inada, Kalembeyi, Imanaka-Yoshida, Sakakibara, Okada, Katsuta, Sakakura, Majima, Yoshida: Involvement of large tenascin-C splice variants in breast cancer progression. in The American journal of pathology 2003
Show all 18 Pubmed References
Rat (Rattus) Monoclonal TNC Primary Antibody for ICC, IHC - ABIN1742432
Siddiqui, Horvat-Bröcker, Faissner: The glia-derived extracellular matrix glycoprotein tenascin-C promotes embryonic and postnatal retina axon outgrowth via the alternatively spliced fibronectin type III domain TNfnD. in Neuron glia biology 2010
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Human Polyclonal TNC Primary Antibody for IHC, IHC (p) - ABIN4358422
Schenke-Layland, Stock, Nsair, Xie, Angelis, Fonseca, Larbig, Mahajan, Shivkumar, Fishbein, MacLellan: Cardiomyopathy is associated with structural remodelling of heart valve extracellular matrix. in European heart journal 2009
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Human Monoclonal TNC Primary Antibody for IHC (p), IP - ABIN94480
Tökés, Hortoványi, Csordás, Kulka, Mózes, Hatalyák, Kádár: Immunohistochemical localisation of tenascin in invasive ductal carcinoma of the breast. in Anticancer research 1999
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Human Monoclonal TNC Primary Antibody for EIA, IHC (p) - ABIN112483
Faustino, van Garderen, Schalken, Nederbragt: Tenascin expression in normal, hyperplastic, dysplastic and neoplastic canine mammary tissues. in Journal of comparative pathology 2002
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Human Polyclonal TNC Primary Antibody for IF (p), IHC (p) - ABIN674994
Kau, Miller, Tichy, Gabriel: S100A4 (metastasin) positive mesenchymal canine mammary tumour spheroids reduce Tenascin C synthesis under DMSO exposure in vitro. in Veterinary and comparative oncology 2017
Show all 2 Pubmed References
Human Polyclonal TNC Primary Antibody for ELISA, WB - ABIN561398
He, Liu, Zhu, Xie, Costello, Talsma, Flack, Crowley, Dimeco, Vescovi, Fan, Lubman: Glycoproteomic analysis of glioblastoma stem cell differentiation. in Journal of proteome research 2011
Human Monoclonal TNC Primary Antibody for IHC (fro), IHC (p) - ABIN2476728
Verstraeten, Mackie, Hageman, Hilgers, Schol, De Jongh, Schalkwijk: Tenascin expression in basal cell carcinoma. in The British journal of dermatology 1993
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Results suggest that sequence variants in TNC and COL5A1 genes are associated with superficial digital flexor tendinopathy in TB racehorses. In
the expression of MUC2, a heavily O-glycosylated glycoprotein that plays an essential role in intestinal function, was uniformly reduced in human colorectal cancer (CRC) tissues as well as in LS174T cells.
this article reviews recent understanding of TLR4 and TNC in SAH to suggest that the TLR4-TNC signaling may be an important therapeutic target for post-SAH brain injuries [review]
no association between TNC variants and risk of anterior cruciate ligament rupture in Polish Caucasians
The circulating level of TNC protein was elevated in acute kidney injury (AKI) patients after cardiac surgery. Study in human proximal tubular epithelial cell line indicated that TNC is renal protective in AKI by potentiating Wnt/beta-catenin signaling and demonstrate that TNC able to recruit and concentrate Wnt ligands, thereby creating a favorable microenvironment for tubular repair and regeneration.
This review presents the current understanding of tenascin-C's involvement in endogenous immunity, and the data emerging that implicate this matrix molecule as a promising biomarker of inflammatory disease status and a tractable target for therapeutic applications. [review]
Elevated serum tenascin-C was found in septic patients and associated with severity and poor prognosis.
Tenascin C and fibronectin are abundantly expressed in pancreatic ductal adenocarcinoma (PDAC), but they seem to have no major association with patient survival.
These findings suggest that pro-angiogenic remodelling of the perivascular matrix may involve TNC-induced upregulation of FN in endothelial cells.
High TNC expression is associated with high Severity of Coronary Atherosclerosis.
Elevated tenascin-C expression is associated with cancer.[meta-analysis]
analysis of genetic variants of COL27A1 and tenascin C in achilles tendinopathy and anterior cruciate ligament ruptures
High tenascin-C levels in depressive patients correlate with suicide attempts and severity of depression.
Suggest a correlation between the degree of inflammation and TN-C expression in the cardiovascular lesions of acute-stage Kawasaki disease.
tenascin-c promoted macrophage migration and VEGF expression through annexin II, the expression of which was modulated by HIF-1alpha.
The simultaneous expression of TNC and Twist1 was significantly higher in stromal fibroblasts of gastric cancer than in noncancerous tissues.
Results illuminate how the extracellular matrix glycoprotein tenascin-C in the tumor microenvironment promotes invasive migration and metastatic progression by employing integrin alpha9beta1, abolishing actin stress fiber formation, inhibiting YAP and its target gene expression.
In addition, we found that Tn-expressing colorectal cancers (CRC) cell lines had either loss-of-function mutations in Cosmc or reversible Tn antigen expression, which was not caused by the deficiency of T-synthase activity
The results demonstrated that ANX2 and stromal tenascin C regulated invasion in addition to stemness and anoikis resistance, which are crucial for metastasis in the progression of pancreatic ductal adenocarcinoma.
Intratumor stromal expression of tenascin-C (TN-C) is a strong prognostic indicator in locally advanced unresectable (UR-LA) pancreatic ductal adenocarcinoma (PDAC) patients with resection after chemoradiotherapy (CRT).
this study shows that tenascin C is increased in vitiligo in lesional areas only in the acral sites
tenascin-C-derived peptide TNIIIA2 may contribute to the formation of colitis-associated colorectal cancer via activation of stromal fibroblasts based on beta1-integrin activation.
Upregulation of tenascin C mRNA was observed with overexpression of Sox4, suggesting a causal relationship between the two events in mammary gland Involution.
Study confirmed that the HNK-1 epitope was primarily expressed on TNC in the embryonic day 16 mouse brain and promoted neurite outgrowth. That this signal was mediated by CNTN, which is an HNK-1-expressing neuronal receptor. These results suggest that the HNK-1 epitope is a key modifier of TNC and CNTN in the regulation of embryonic brain development.
this study shows that tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors
Study investigated TNC expression and function in both ischemic and toxic mouse models of acute kidney injury (AKI). Results indicated that Tnc is renal protective in AKI by potentiating Wnt/beta-catenin signaling and demonstrate that Tnc able to recruit and concentrate Wnt ligands, thereby creating a favorable microenvironment for tubular repair and regeneration.
Studied role of leptin, iNOS and tenascin C in development of adipose tissue inflammation, extracellular matrix remodeling, and fibrosis in leptin knockout obese mice.
the present study demonstrates for the first time the importance of TN-C in the progression of LV dysfunction under chronic pressure overload. TN-C-KO mice showed preserved cardiac function and inhibit the enlargement of LV.
Compared with wild-type subarachnoid hemorrhage mice, Tenascin-C knock-out subarachnoid hemorrhage mice showed better neurological scores and less cerebral vasospasm.
By promoting a pro-inflammatory microenvironment and macrophage migration, TNC appears to be a key factor to enable the monocyte/macrophage accumulation within fibrotic hearts leading to cardiac dysfunction.
TNC causes post-subarachnoid hemorrhage neuronal apoptosis and neuroinflammation.
Results identify tenascin-C as an endogenous danger signal that is upregulated in systemic sclerosis and drives TLR4-dependent fibroblast activation, and by its persistence impedes fibrosis resolution.
ATF3 promotes macrophage migration and reverses M1polarized macrophages to the M2 phenotype by upregulation of TNC via the Wnt/betacatenin signaling pathway.
housing of TnC-/- mice in enriched environment abolished hyperlocomotion, led to faster habituation to novel environment, strengthened the grasp of fore limbs and partially improved movement coordination, while the swimming ability remained deficient
The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack tenascin-C, the informational content stored by synaptic plasticity is not the same.
Study suggests that tenascin-C (TnC) contributes to the regulation of structural plasticity in the cerebellum and that interactions between TnC and matrix metalloproteinase 9 are likely to be important for these processes to occur.
the exact role of TNC in primary tumor growth
A deficiency of tenascin C interferes with Th1 and Th17 cells, protecting animals from experimental autoimmune encephalomyelitis.
secreted by transdifferentiated retinal pigment epithelial cells and promotes the development of choroidal neovascularization via integrin alphaV in a paracrine manner
Tenascin-C may be an important mediator in the development of brain edema and blood-brain barrier disruption following subarachnoid hemorrhage, mechanisms for which may involve MAPK-mediated MMP-9 induction and ZO-1 degradation
TNC does not appear to contribute directly to outflow resistance in the eye.
TNC could be a potential candidate gene for meat quality traits in pigs.
tenascin binds to fibronectin at a cryptic binding site
Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers. Increase of rat soleus muscle loading modifies basement membrane of damaged muscle fibers through ectopic endomysial expression of tenascin-C.
tenascin-C is part of a specialized extracellular matrix in the region of the horizontal myoseptum that influences the growth of motor axons
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.
, tenascin C (hexabrachion)
, GP 150-225
, glioma-associated-extracellular matrix antigen
, hexabrachion (tenascin)
, myotendinous antigen
, tenascin-C isoform 14/AD1/16