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anti-Immunoglobulin A (IgA) secondary antibodies

Immunoglobulin A plays a role in mucosal immunity and is produced in mucosal linings. Hence IgA can be found in mucous secretions, including tears, saliva, colostrum, secretions from the gastrointestinal tract, and others, but it is found only in small amounts in blood.

anti-Immunoglobulin A (IgA)  antibody

Secretory Immunoglobulin A (sIgA)

The amount of IgA produced in is greater than all other types of antibody combined. 15% of total immunoglobulins produced throughout the body are IgAs, which accounts for about 4 grams each day.

There are two isotypes, (90%) and (10%), They are both heavily glycosylated proteins with IgA1 being found in serum and produced in bone marrow B cells, and , being secreted into colostrum, maternal milk, tears and saliva. IgA can exist as a monomer or in a dimeric form called secretory IgA (sIgA).

Secretory IgA (sigA)

The secretory IgA consists of polymers of two IgA monomers linked by additional so-called J-chains and a secretory component that is wrapped around the IgA dimer in order to protect it from proteolytic digestion in the intestinal tract.

Some bacteria release a protease that destroys IgA which can be utilized in biotechnological experiments. These include Neisseria gonorrhoeae, Streptococcus pneumoniae, and Haemophilus influenzae type B.

Selection of anti-IgA secondary antibodies

Reactivity Host Unconj. AP Biotin FITC HRP TRITC PE
Human Goat ABIN336538 ABIN336539 ABIN336540 ABIN376135 ABIN336542 ABIN336543 ABIN376513
Human Goat ABIN336545 ABIN336546 ABIN336547 ABIN100718 ABIN336549 ABIN336550 ABIN376514
Human Goat ABIN336552 ABIN336553 ABIN336554 ABIN637059 ABIN336556 ABIN336557 ABIN5624019
Human Mouse ABIN135640 ABIN135641 ABIN336543 - ABIN135642 - ABIN6156299
Human Rat ABIN135040 ABIN135042 ABIN135044 ABIN135041 ABIN135043 - -
Chicken Mouse ABIN135557 - ABIN135558 ABIN135559 - - ABIN376560

Links to other secondary antibody-types