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anti-Immunoglobulin E (IgE) secondary antibodies

anti-Immunoglobulin E (IgE)  antibody

anti-Immunoglobulin E (IgE) antibody

IgE is only found in mammals. IgE is the least abundant isotype of all antibodies, but it is capable of triggering the most powerful immune reactions. IgE plays an important role in allergy, and leads to excessive activation of mast cells and basophils by binding to their Fc receptors, resulting in an extreme inflammatory response.

IgE is able to bind to to versions of Fcε receptors:

  • FcεRI (type I Fcε receptor), the high-affinity IgE receptor
  • FcεRII (type II Fcε receptor), also known as CD23, the low-affinity IgE receptor

Function in mammalian body

IgEs have co-evolved with basophils and mast cells in the defence against parasites like helminths (like Schistosoma) but may be also effective in bacterial infections. Epidemiological research shows that IgE level is increased when infected by Schistosoma mansoni and nematodes in humans. It is most likely beneficial in removal of hookworms from the lung.

Except its established function for allergy, there is still speculation about the physiological contributions of IgE. In animal models circumstantial evidence hints to IgE fighting gut parasites like parasitic worms, but this has not been conclusively proven in humans. IgE may play some role in the immune system's recognition of cancer. However, so far there is only circumstantial evidence for this hypothesis though, like for example the observation that the prevalence of several cancers is lower in individuals with allergies. Additionally, treatment with immunesystem-suppressing substances increases the cancer risk. Interestingly, individuals with allergies have lower level of toxins. It is thought possible, that IgE bind an help to destroy or excrete toxins.

Below you will find a list of anti- secondary antibodies.

Anti-Immunoglobulin E (IgE)

Reactivity Host Unconj. AP Biotin FITC HRP TRITC PE
Human Goat ABIN336559 ABIN336560 ABIN336561 ABIN929719 ABIN336563 ABIN336564 ABIN3045684
Human (Fc) Mouse ABIN135648 ABIN135649 ABIN135651 ABIN5707454 ABIN135650 - -
Human (Fc) Mouse ABIN135673 ABIN135674 ABIN135676 ABIN5707455 ABIN135675 - -
Human Mouse ABIN135034 ABIN135036 ABIN135038 ABIN135035 ABIN135037 ABIN457880 ABIN3045684

Links to other secondary antibody-types