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Human Polyclonal ATG7 Primary Antibody for IF, IHC (p) - ABIN388522
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
Show all 13 Pubmed References
Human Polyclonal ATG7 Primary Antibody for ICC, IF - ABIN269462
Park, Lee, Kim, Lee, Lee, Kim, Jang, Choi, Kwon, Kim: A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells. in Cancer research 2007
Show all 4 Pubmed References
Human Polyclonal ATG7 Primary Antibody for IHC (p), WB - ABIN4282130
Lee, Chen, Su, Chueh: Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death. in Journal of agricultural and food chemistry 2015
Show all 2 Pubmed References
Human Polyclonal ATG7 Primary Antibody for EIA, WB - ABIN118061
Aoki, Kobayashi, Tanida, Hatano, Komori, Matsumoto, Nishioka, Uemura: [A difficult case of esophageal and gastric double cancer with pleural and pericardial effusion following chemo-radiotherapy (CRT)] in Gan to kagaku ryoho. Cancer & chemotherapy 2008
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Human Polyclonal ATG7 Primary Antibody for IHC (p), WB - ABIN388521
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
Show all 9 Pubmed References
Human Monoclonal ATG7 Primary Antibody for WB - ABIN387793
Metzger, Saukko, Van Che, Tong, Puder, Riess, Nguyen: Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. in Human genetics 2010
Show all 6 Pubmed References
Human Polyclonal ATG7 Primary Antibody for IHC (p), WB - ABIN388520
Greenberg: Degrade or die: a dual function for autophagy in the plant immune response. in Developmental cell 2005
Show all 8 Pubmed References
Human Polyclonal ATG7 Primary Antibody for IF, IHC (p) - ABIN388523
Levine: Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. in Cell 2005
Show all 8 Pubmed References
PSMD10/gankyrin (show PSMD10 Antibodies) has a role in inducing autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression
the ATG5 (show ATG5 Antibodies)-ATG7-NCOA4 (show NCOA4 Antibodies) autophagic pathway has a role in ferroptosis
knockdown of autophagy genes ATG5 (show ATG5 Antibodies) or ATG7 resulted in reduced hematopoietic stem/progenitor cell frequencies in vitro as well as in vivo.
Nine of the 32 (28.1%) iCCA (show PRRT2 Antibodies) patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (show RNF2 Antibodies) mutations, two each (6.3%) of CACNA2D3 (show CACNA2D3 Antibodies) and RASSF1 (show RASSF1 Antibodies) mutations, and one each (3.1%) of ATG7 and PLCD1 (show PLCD1 Antibodies) mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
knockdown of ATG7 results in decreased glycolysis and increased flux of labeled carbons through the mitochondrial tricarboxylic acid cycle.
SNP rs11706903 in ATG7 was not associated with systemic lupus erythematosus I Chinese Han population.
low serum ATG7 is associated with ulcerative colitis
The U2AF35 (show U2AF1 Antibodies)(S34F) mutation alters interaction with CFIm59 (show CPSF7 Antibodies), leading to increased use of a distal cleavage and polyadenylation site in the ATG7 pre-mRNA, decreasing levels of ATG7 protein and defective autophagy, ultimately leading to transformation.
the inhibition of Atg7 appears to be a valid strategy to enhance chemosensitivity, and it could indeed improve outcomes in acute myeloid leukemia (show BCL11A Antibodies) therapy.
Our data demonstrate that HOTAIR promotes the activation of autophagy in HCC (show FAM126A Antibodies) cells by upregulating the expression of the autophagy-related genes ATG3 (show ATG3 Antibodies) and ATG7.
Autophagy deficiency induced by RPE (show RPE Antibodies)-specific deletion of Atg5 (show ATG5 Antibodies) or Atg7 predisposes but does not necessarily drive the development of AMD (show AMD1 Antibodies)-like phenotypes or retinal degeneration.
ATG7 has a role in autophagy deficiency in macrophages that may contribute to the progression of metabolic syndrome associated with lipid injury and colitis
ATG proteins ATG5 (show ATG5 Antibodies) and ATG7 may be required for phagosome maturation under some conditions, but are not universally required for this process
Autophagy and tumorigenesis were not increased in Atg7(+/-) mice kept in social isolation and fed OID. Thus, social isolation may increase breast cancer risk by inducing autophagy, independent of changes in body weight.
ATG7, but not ATG13 (show ATG13 Antibodies) or ULK1 (show ULK1 Antibodies) has a role in functional autophagy in glioblastoma development
Atg7 is critical for the survival of midbrain dopaminergic (mDA) neurons in physiological condition. Atg7 is up-regulated when exposed to MPTP (show PTPN2 Antibodies), but unlike in the control mice, chronic MPTP (show PTPN2 Antibodies) treatment did not lead to loss of mDA neurons in Atg7 conditional knockout mice. These results suggest that excessive Atg7-involved autophagy in the pathological condition has deleterious effects on the survival of mDA neurons.
It shows that AMBRA1 (show AMBRA1 Antibodies), but not ATG7, plays a role in TCR-mediated control of glycolytic factors and mitochondrial mass, while both AMBRA1 (show AMBRA1 Antibodies) and ATG7 are required for autolysosome formation.
Collectively, these data reveal that miR (show MLXIP Antibodies)-20a inhibits autophagic response and promotes BCG (show SLC11A1 Antibodies) survival in macrophages by targeting ATG7 and ATG16L1 (show ATG16L1 Antibodies).
Beta-Atg7 (-/-) mice had proinsulin (show INS Antibodies)-containing sequestosome 1 (p62 (show SQSTM1 Antibodies) [also known as SQSTM1 (show SQSTM1 Antibodies)])(+) aggregates in beta cells, indicating proinsulin (show INS Antibodies) is regulated by autophagy in vivo. Short-term bafilomycin-A1 treatment and ATG5 (show ATG5 Antibodies)/7 knockdown increased steady-state proinsulin (show INS Antibodies) and hormone precursor chromogranin A (show CHGA Antibodies) content. ATG5 (show ATG5 Antibodies)/7 knockdown also increased glucose- and non-fuel-stimulated insulin (show INS Antibodies) secretion.
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes.
autophagy-related protein 7
, Autophagy-related protein 7
, ATG7 autophagy related 7 homolog
, ATG12-activating enzyme E1 ATG7
, ubiquitin activating enzyme E1-like protein
, ubiquitin-activating enzyme E1-like protein
, ubiquitin-like modifier-activating enzyme ATG7
, autophagy-related 7
, autophagy related 7 homolog
, potential E1-like Atg12p-Atg5p conjugation enzyme Atg7