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PFT exhibits broad specificity for CaaX substrates
Used to demonstrate the feasibility of bimolecular fluorescence complementation in plants.
These findings collectively suggest that the combination of farnesyltransferase inhibitors and gamma-secretase inhibitors is a promising therapeutic strategy for glioblastoma through selectively targeting the cancer stem cell subpopulation.
Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit
our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability
Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site.
Geranylgeranyltransferase inhibitor-2147 (GGTI-2147), an inhibitor of protein prenylation, elicited significant inhibition of glucose-stimulated insulin secretion from INS 832/13 islet cells.
FTase, via its tubulin-association, is a critical upstream regulator of HDAC6 activity
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13.
, farnesyl-protein transferase alpha-subunit
, protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
, protein prenyltransferase alpha subunit repeat containing 2
, ras proteins prenyltransferase subunit alpha
, type I protein geranyl-geranyltransferase alpha subunit
, CAAX farnesyltransferase subunit alpha
, type I protein geranyl-geranyltransferase subunit alpha
, Farnesyltransferase, subunit alpha