FNTA antibody

Catalog No. ABIN1386076

Product Details anti-FNTA Antibody

Target: FNTA (Farnesyltransferase, CAAX Box, alpha (FNTA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FNTA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PGGT1A/FNTA

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FNTA

Target: FNTA (Farnesyltransferase, CAAX Box, alpha (FNTA))

Alternative Name: PGGT1A (FNTA Products)

Background:

Synonyms: CAAX farnesyltransferase alpha subunit, Farnesyl protein transferase alpha subunit, Farnesyltransferase CAAX box alpha, Farnesyltransferase, CAAX box, alpha, FPTA, FTase alpha, GGTase I alpha, PGGT1A, Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein prenyltransferase alpha subunit repeat containing 2, PTAR2, Ras proteins prenyltransferase alpha, Ras proteins prenyltransferase subunit alpha, Type I protein geranyl geranyltransferase alpha subunit, FNTA_HUMAN.

Background: FNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localization of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence. FNTA is also a specific cytoplasmic interactor of the transforming growth factor-beta and activin type I receptors. It is likely to be a key component of the signaling pathway which involves p21ras, an important substrate for farnesyltransferase.

Gene ID: 2339

Pathways: Response to Water Deprivation, Regulation of G-Protein Coupled Receptor Protein Signaling