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anti-Human CNOT1 Antibodies:
anti-Mouse (Murine) CNOT1 Antibodies:
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the CNOT1-LMNA (show LMNA Antibodies)-Hedgehog (show SHH Antibodies) signaling pathway axis exerts an oncogenic role in osteosarcoma progression, which could be a potential target for gene therapy.
we demonstrate that joint deletion of two short conserved motifs that bind UNR (show P2RY4 Antibodies) and DDX6 (show DDX6 Antibodies) relieves repression of 4E-T (show EIF4ENIF1 Antibodies)-bound mRNA, in part reliant on the 4E-T (show EIF4ENIF1 Antibodies)-DDX6 (show DDX6 Antibodies)-CNOT1 axis.
miRNAs, AGOs, GW182, the CCR4 (show CCR4 Antibodies)-NOT complex, and DDX6/Me31B (show DDX6 Antibodies) repress and degrade polyadenylated mRNA targets that are translated via scanning-independent mechanisms in both human and Drosophila melanogaster cells
Single nucleotide polymorphism in CNOT1 gene is associated with osteosarcoma susceptibility.
CNOT1 facilitates recruitment of DDX6 (show DDX6 Antibodies) to miRNA-targeted mRNAs, placing DDX6 (show DDX6 Antibodies) as a downstream effector in the miRNA silencing pathway.
Crystal structures of the DDX6 (show DDX6 Antibodies), CNOT1 and CNOT9 (show RQCD1 Antibodies) complexes.
Crystal structure of the DDX6 (show DDX6 Antibodies), CNOT9 (show RQCD1 Antibodies) and CNOT1 complex.
The CNOT2 (show CNOT2 Antibodies)-CNOT3 (show CNOT3 Antibodies) heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure.
Authors identify an evolutionarily conserved C-terminal motif in human TTP (show ADAMTS13 Antibodies) that directly binds a central domain of CNOT1, a core subunit of the CCR4 (show CCR4 Antibodies)-NOT complex.
The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates.
Collectively, our data support a model of CNOT7 (show CNOT7 Antibodies), TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis
These data have uncovered a novel role of core components of the Ccr4 (show CCR4 Antibodies)-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
Cnot1, Cnot2 (show CNOT2 Antibodies), and Cnot3 (show CNOT3 Antibodies) represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs (show NR2E3 Antibodies).
Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity).
CCR4-NOT transcription complex subunit 1
, CCR4-associated factor 1
, NOT1 (negative regulator of transcription 1, yeast) homolog
, adrenal gland protein AD-005
, negative regulator of transcription subunit 1 homolog
, CCR4-NOT transcription complex, subunit 1
, CCR4-NOT transcription complex subunit 1-like
, LOW QUALITY PROTEIN: CCR4-NOT transcription complex subunit 1