CNOT1 antibody (AA 2137-2376)

Catalog No. ABIN6138777

Product Details anti-CNOT1 Antibody

Target: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Binding Specificity: AA 2137-2376

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNOT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: PRNMRLPDPF TPNLKVDMLS EINIAPRILT NFTGVMPPQF KKDLDSYLKT RSPVTFLSDL RSNLQVSNEP GNRYNLQLIN ALVLYVGTQA IAHIHNKGST PSMSTITHSA HMDIFQNLAV DLDTEGRYLF LNAIANQLRY PNSHTHYFSC TMLYLFAEAN TEAIQEQITR VLLERLIVNR PHPWGLLITF IELIKNPAFK FWNHEFVHCA PEIEKLFQSV AQCCMGQKQA QQVMEGTGAS

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2137-2376 of human CNOT1 (NP_057368.3).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CNOT1

Target: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Alternative Name: CNOT1 (CNOT1 Products)

Synonyms: CDC39 antibody, NOT1 antibody, NOT1H antibody, 6030411K04Rik antibody, AA815922 antibody, D830048B13 antibody, RGD1308009 antibody, GB18988 antibody, cdc39-like antibody, im:7141761 antibody, kiaa1007l antibody, wu:fc58h04 antibody, zgc:152902 antibody, CNOT1 antibody, not1 antibody, cdc39 antibody, not1h antibody, ad-005 antibody, NV18106 antibody, CCR4-NOT transcription complex subunit 1 antibody, CCR4-NOT transcription complex, subunit 1 antibody, CNOT1 antibody, Cnot1 antibody, LOC412371 antibody, cnot1 antibody, LOC100114396 antibody

Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES cell identity.,CNOT1,AD-005,CDC39,NOT1,NOT1H,Epigenetics & Nuclear Signaling,RNA Binding,CNOT1

Molecular Weight: 173 kDa/241 kDa/266 kDa

Gene ID: 23019

UniProt: A5YKK6

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance