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Based on the analysis of the TGIF1-homeodomain (HD) NMR structure determined here, the roles of two holoprosencephaly-related residues P192 and R219 in sufficient folding of TGIF1-HD were revealed. Mutations of these two residues, P192A and R219C found in holoprosence patients previously, resulted in structural change and less folding of TGIF1-HD, and thereby severely impaired the DNA-binding affinity of TGIF1-HD.
High TGIF-1 expression is associated with fetal growth restriction.
Tgifs regulate ciliogenesis and suggests that Evi5l (show EVI5L Proteins) mediates at least part of this effect.
Knockdown of TGIF1 resulted in decreased protein expression of HOXD10 (show HOXD10 Proteins) and increased resistance to colistin cytotoxicity in renal cells.
Data show that the silencing of TG-interacting factor (TGIF) inhibited A549 lung cancer cell proliferation, growth of tumor xenograft in vivo, and arrested the cell cycle in the G1 phase.
we suggest that TGIF (show IL10 Proteins) plays an important role in low-dose arsenic-induced malignant transformation of HaCaT cells, which is regulated by c-Src (show SRC Proteins)/EGFR (show EGFR Proteins)/AKT (show AKT1 Proteins)/FOXO3A (show FOXO3 Proteins) pathway and redox signaling.
crystal structures of human IZUMO1 (show IZUMO1 Proteins), JUNO and the IZUMO1 (show IZUMO1 Proteins)-JUNO complex, establishing the structural basis for the IZUMO1 (show IZUMO1 Proteins)-JUNO-mediated sperm-oocyte interaction
crystal structures of human IZUMO1 (show IZUMO1 Proteins) and JUNO in unbound and bound conformations
Corneal fibroblasts demonstrate the expression of TGIF1 and TGIF2 (show TGIF2 Proteins) transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea.
Our results suggested that elevated expression of TGIF (show IL10 Proteins) was involved in lung carcinogenesis.
loss of Tgif1 causes axial patterning defects that are enhanced by mutations in Tgif2 (show TGIF2 Proteins)
Tgif2 (show TGIF2 Proteins) participates in photoreceptor cell differentiation in the early stages of retinal development and regulates proper subretinal localization of the cone photoreceptors.
Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells.
Tgif1 suppresses stem cell self-renewal.
The identification and characterization of the Tgif mutant supports the role of TGFbeta (show TGFB1 Proteins) signalling in the development of chronic OM.
Tgif1 mutation in mouse contributes to Holoprosencephaly pathogenesis due to disruption of the Shh (show SHH Proteins) pathway
TGIF1 plays a role in TNF-alpha (show TNF Proteins)- and radiation-induced inflammation and it could be a target in limiting this event in the vascular compartment
TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) co-repressor TGIF1 plays a role in radiation-induced normal tissue damage by a Smad (show SMAD1 Proteins)-independent mechanism.
Data suggest that in the absence of Tgif1, a persistent increase in TGFbeta (show TGFB1 Proteins) responsive transcription and a reduced ability to deal with hyperoxic stress result in premature senescence in primary MEFs.
Tgif1 expression and regulation of TGFbeta (show TGFB1 Proteins) signaling are implicated in the function of several types of stem cells, but this is the first demonstration that this regulatory network is necessary for regeneration of neurons.
Tgif is necessary for normal initiation of genes that control RA synthesis and degradation, resulting in defects in RA-dependent central nervous system patterning in Tgif-depleted embryos.
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005
5'-TG-3'-interacting factor 1
, TALE homeobox TG-interacting factor
, homeobox protein TGIF1
, transforming growth factor-beta-induced factor
, izumo sperm-egg fusion protein 1
, oocyte binding/fusion factor
, sperm-specific protein Izumo
, TALE family homeobox
, TG interacting factor 1
, TG interacting factor
, TGFB-induced factor (TALE family homeobox)
, avian knotted-related protein
, homeobox protein AKR
, homeodomain protein AKR
, TG-interacting factor
, TGFB-induced factor homeobox 1
, TG-interacting homeobox protein
, TGFB induced factor homeobox 1 S homeolog