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Human Polyclonal CD2BP2 Primary Antibody for ELISA, IHC - ABIN250400
Nishizawa, Freund, Li, Wagner, Reinherz: Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation. in Proceedings of the National Academy of Sciences of the United States of America 1999
Knockdown of CD2BP2 results in reduced miRNA levels. CD2BP2 stabilizes miRISC and mature miRNAs, maintaining them at levels necessary to properly regulate target gene expression.
CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments.
there is a function of the GYF domain of CD2BP2 in mediating protein-protein interactions within the spliceosome
interaction of CD2BP2 with a tri-snRNP bridging protein (Prp6), coupled with CD2BP2's absence from the tri-snRNP, suggests it might function in tri-snRNP assembly
findings indicate that CD2BP2 is not a constitutive binding partner or key regulator of CD2-mediated signaling events
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.
CD2 antigen (cytoplasmic tail) binding protein 2
, CD2 antigen cytoplasmic tail-binding protein 2
, CD2 cytoplasmic domain-binding protein 2
, U5 snRNP 52K protein
, protein phosphatase 1, regulatory subunit 59
, CD2 tail-binding protein 2