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HBx activates NF-kappaB to promote the expression of miR1269b, which augments CDC40 expression, contributing to malignancy in hepatocellular cancer.
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.
pre-mRNA-processing factor 17
, cell division cycle 40 homolog
, hypothetical protein
, cell division cycle 40 homolog (S. cerevisiae)
, pre-mRNA-processing factor 17-like
, Pre-mRNA-processing factor 17
, splicing factor Prp17
, nuclear pre-mRNA splicing factor, component of the spliceosome
, mRNA splicing factor PRP17
, EH-binding protein 3
, PRP17 homolog
, pre-mRNA splicing factor 17