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the S. pombe ICln protein is required for optimal production of the spliceosomal snRNPs and for efficient splicing in vivo
functional interaction between ICln and HSPC038
RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.
revealed an increase of ICln in the mesothelioma cell membrane under hypotonic conditions, an event possibly related to the activation of Cl(-) channels
ICln interacts with integrin alphaIIbbeta3 and regulates platelet activation.
Data show that ICln159, a truncated ICln mutant, belongs to the pleckstrin homology (PH) domain family of proteins and interacts with LSm4, a protein involved in splicing and mRNA degradation.
Lsm10 and Lsm11, which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln in vitro and in vivo without receiving sDMA modifications and with PRMT5 and SMN complexes
ICln associates with the cell membrane after cell swelling
1st demonstration of VSOR Cl- channel expression in somatosensory pyramidal neurons. It is the major anionic pathway for varicosity recovery after NMDA & for persistent NMDA-induced varicosity formation leading to necrosis in cortical neurons.
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6.
chloride channel regulatory protein
, chloride channel, nucleotide sensitive 1A
, chloride conductance regulatory protein ICln
, chloride ion current inducer protein
, methylosome subunit pICln
, reticulocyte pICln
, reticulocyte protein ICln
, chloride channel current inducer
, chloride channel regulator
, Clns 1a
, chloride channel, nucleotide-sensitive, 1A
, swelling-induced chloride conductance regulatory protein
, swelling dependent chloride channel