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Data show that crooked neck activity appears essential as extracts depleted of hcrn fail to splice pre-mRNA. These and related data support the view that crooked neck is a phylogenetically conserved pre-mRNA splicing factor.
The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. This gene is similar in sequence to crn and encodes a protein which can localize to pre-mRNA splicing complexes in the nucleus. The encoded protein, which contains many tetratricopeptide repeats, is required for pre-mRNA splicing.
Crn, crooked neck-like 1
, SYF3 pre-mRNA-splicing factor
, crooked neck homolog
, crooked neck-like 1
, crooked neck-like protein 1
, crooked neck-like 1 protein
, crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
, crooked neck-like protein 1-like
, Crooked neck homolog
, Crooked neck protein
, crooked neck pre-mRNA splicing factor-like 1
, crooked neck-like 1 protein-like