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anti-Human DDX3X Antibodies:
anti-Mouse (Murine) DDX3X Antibodies:
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Human Polyclonal DDX3X Primary Antibody for ICC, IF - ABIN152330
Kang, Tsoi, Zhu, Su, Kay: Differential gene expression profiling in HELLP syndrome placentas. in Reproductive sciences (Thousand Oaks, Calif.) 2008
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Human Polyclonal DDX3X Primary Antibody for ICC, IF - ABIN4304628
Hagerstrand, Tong, Schumacher, Ilic, Shen, Cheung, Vazquez, Shrestha, Kim, Giacomelli, Rosenbluh, Schinzel, Spardy, Barbie, Mermel, Weir, Garraway, Tamayo, Mesirov, Beroukhim, Hahn: Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers. in Cancer discovery 2013
Show all 3 Pubmed References
Human Polyclonal DDX3X Primary Antibody for ICC, ELISA - ABIN1002200
Park, Lee, Kim, Song: Assignment of a human putative RNA helicase gene, DDX3, to human X chromosome bands p11.3-->p11.23. in Cytogenetics and cell genetics 1998
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Human Polyclonal DDX3X Primary Antibody for ICC, ELISA - ABIN1002199
Abdelhaleem: RNA helicases: regulators of differentiation. in Clinical biochemistry 2005
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Human Polyclonal DDX3X Primary Antibody for IF, WB - ABIN2451947
Sekiguchi, Iida, Fukumura, Nishimoto: Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation. in Experimental cell research 2004
Human Polyclonal DDX3X Primary Antibody for IHC (p), WB - ABIN388291
Ariumi, Kuroki, Abe, Dansako, Ikeda, Wakita, Kato: DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication. in Journal of virology 2007
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DDX3 regulates MTP (show MT1B Antibodies) gene expression and lipid homeostasis through interplay with HNF4 (show HNF4A Antibodies) and SHP (show LAMC1 Antibodies).
Through adopting the immunoprecipitation (IP), RNA immunoprecipitation (RIP), dual luciferase reporter assays, the authors illustrate that DDX3X could interact with Drosha/DGCR8 complex, elevate the processing activity of Drosha/DGCR8 complex on pri-miRNAs, and increase mature miRNA expression levels.
our study suggested that DDX3 prevents generation of cancer stem cells through epigenetically regulating a subset of tumor-suppressive miRNAs expressions, which strengthens tumor suppressor role of DDX3 in hepatocellular carcinoma.
this study shows that cancer-associated DDX3X mutations drive stress granule assembly and impair global translation
we demonstrated that DDX3 modulated the activity of PP2A (show PPP2R4 Antibodies) by controlling the phosphorylation of PP2A (show PPP2R4 Antibodies)-C, which might enable PP2A (show PPP2R4 Antibodies)-C to regulate NF-kappaB (show NFKB1 Antibodies) signal pathway by dephosphorylating IKK-beta (show IKBKB Antibodies).
Data suggest that L protein from LCMV interactions with host proteome, specifically DDX3X, NKRF (show NKRF Antibodies), and TRIM21 (show TRIM21 Antibodies). (LCMV = Lymphocytic choriomeningitis mammarenavirus; DDX3X = DEAD-box helicase 3; NKRF (show NKRF Antibodies) = NF-kappa-B-repressing factor (show NKRF Antibodies); TRIM21 (show TRIM21 Antibodies) = tripartite motif-containing protein-21 (show TRIM21 Antibodies))
DDX3 interacts extensively with RNA and ribosomal machinery to help remodel the translation landscape in response to stress, while cancer-related DDX3 variants adapt this response to selectively preserve translation
Mechanistically, increased KRAS expression induced ROS (show ROS1 Antibodies) production, which elevated HIF-1alpha (show HIF1A Antibodies) and YAP1 (show YAP1 Antibodies) expression. Increased HIF-1alpha (show HIF1A Antibodies) persistently promoted DDX3 expression via a KRAS/ROS (show ROS1 Antibodies)/HIF-1alpha (show HIF1A Antibodies) feedback loop.
Our study suggests that rottlerin exhibits its anti-cancer activity partly due to upregulation of DDX3 in hepatocellular carcinoma cells.
DDX3 may play an oncogenic role to promote tumor growth and invasion in colon cancer cells
This study demonstrated that DDX3 regulates the translation of both Prkaca (show PRKACA Antibodies) and Rac1 (show RAC1 Antibodies) mRNAs in neurons and therefore maintains the PKA-Rac1 (show RAC1 Antibodies) signaling axis at neurite terminals for both neurite outgrowth and dendritic spine formation.
Targeted Ddx3x ablation in the epiblast leads to widespread apoptosis and abnormal growth, which causes embryonic lethality in the Sox2 (show SOX2 Antibodies)-cre/+;Ddx3x(flox)/Y mutant around E11.5.These results have uncovered that mouse Ddx3x is essential for both embryo and extraembryonic development (show UBR5 Antibodies)
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. Alternative splicing results in multiple transcript variants.
ATP-dependent RNA helicase DDX3X
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
, DEAD box protein 3, X-chromosomal
, DEAD box, X isoform
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3
, DEAD/H box-3
, helicase like protein 2
, helicase-like protein 2
, D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3
, D1Pas1-related sequence 2
, DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3
, DEAD box RNA helicase DEAD3
, DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2)
, embryonic RNA helicase
, fibroblast growth factor inducible 14
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
, ATP-dependent RNA helicase DDX3X-like