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EIF3C overexpression was correlated to age and tumor stage in prostate cancer patients and indicated poor survival. The proliferation, migration, and invasiveness of PC3 cells were all inhibited after EIF3C knockdown. Phosphorylation level of PI3K and Akt and total NF-kappaB and Myc decreased after EIF3C knockdown. Therefore, EIF3C at least partially regulates the activity of PI3K/Akt/NF-kappaB signaling pathway in PC3...
In EIF3C-positive tumors, 32 out of 42 showed significantly higher frequencies of high grade group by immunoreactivity.
High eIF3c expression is positively associated with KRAS.
These findings suggest that eIF3c is overexpressed in human gliomas and essential for their proliferation and survival.
eIF3a and eIF3c control abundance and assembly of the entire eIF3 and thus represent its crucial scaffolding elements critically required for formation of preinitiation complexes.
eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome.
Collectively, eIF3c deletion effectively reduced the survival of colon cancer cells and could be used as a therapeutic tool for colon cancer therapy.
These results indicate that the interaction between Hsp90 and eIF3c may play an important role in hepatitis C virus internal ribosome entry site-mediated translation.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (By similarity).
eukaryotic translation initiation factor 3 subunit 8
, eukaryotic translation initiation factor 3 subunit C
, eukaryotic translation initiation factor 3, subunit 8, 110kDa
, eIF3 p110
, Eukaryotic translation initiation factor 3 subunit 8
, eIF3-S8 protein
, Eukaryotic translation initiation factor 3 subunit C
, cell migration-inducing protein 17
, eukaryotic translation initiation factor 3, subunit 8 (110kD)
, NIPI-like protein
, eukaryotic translation initiation factor 3, subunit 8 (110 kDa)
, extra-toes spotting
, eukaryotic translation initiation factor 3, subunit C