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Human GEMIN5 Protein expressed in HEK-293 Cells - ABIN2721790
Francisco-Velilla, Fernandez-Chamorro, Ramajo, Martinez-Salas: The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation. in Nucleic acids research 2016
the WD40 domain (show DCAF12L2 Proteins) of Gemin5 is both necessary and sufficient for binding the Sm site of pre-snRNAs
provide mechanistic understandings of Gemin5's snRNA-binding specificity as well as valuable insights into the molecular mechanism of RNA binding by WD40 (show DCAF12L2 Proteins) repeat proteins in general.
These results reveal the ribosome-binding capacity of the N-ter (show TECR Proteins) moiety, enabling Gemin5 to control global protein synthesis.
Gemin5 is dispensable for snRNA identification and snRNP (show LSM2 Proteins) assembly.
This work both reveals a new autoregulatory pathway governing SMN (show STMN1 Proteins) expression, and identifies a new mechanism through which SMN (show STMN1 Proteins) can modulate specific mRNA expression via Gemin5.
The C-terminal region of Gemin5 bears two non-canonical bipartite RNA-binding sites.
The Gemin5's function in delivering pre-snRNAs as substrates for Sm core assembly and processing.
gemin5 has a role as a novel cap-binding protein (show EIF4E Proteins) and WD repeat domains are involved in m(7)G recognition
we report the identification of an additional component of the SMN (show STMN1 Proteins) complex, a novel WD repeat protein termed Gemin5. Gemin5 binds SMN (show STMN1 Proteins) directly and is a component of the SMN (show STMN1 Proteins) complex
Gemin5 is the snRNA binding protein of the SMN (show STMN1 Proteins) complex, binding directly and specifically to the unique features of snRNAs and is the factor that allows the SMN (show STMN1 Proteins) complex to distinguish snRNAs from other cellular RNAs for snRNP (show LSM2 Proteins) biogenesis
This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
gem-associated protein 5