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Identification and characterization a novel protein component of the survival of motor neurons complex termed Gemin7 using native purified SMN (show STMN1 Proteins) complexes and peptide sequencing by mass spectrometry
Unrip (show STRAP Proteins) is recruited to the active SMN (show STMN1 Proteins) complex via a stable interaction with Gemin7
Gemin8 (show GEMIN8 Proteins) has an essential role in the proper structural organization of the SMN (show STMN1 Proteins) complex and the involvement of the heteromeric subunit containing Gemin6 (show GEMIN6 Proteins), Gemin7, Gemin8 (show GEMIN8 Proteins), and Unrip (show STRAP Proteins) in the recruitment of Sm proteins to the snRNP (show LSM2 Proteins) assembly pathway
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear 'gems' (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.
gem-associated protein 7
, gemin 7
, gem (nuclear organelle) associated protein 7