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Human Polyclonal NCBP1 Primary Antibody for WB - ABIN1881565
Hwang, Sato, Tang, Matsuda, Maquat: UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. in Molecular cell 2010
Show all 5 Pubmed References
Human Polyclonal NCBP1 Primary Antibody for WB - ABIN6138009
Shi, Zhang, Wu, He, Wang, Yin, Tian, Li, Cheng: ALYREF mainly binds to the 5' and the 3' regions of the mRNA in vivo. in Nucleic acids research 2017
Data show that Cbp80 knockdown not only led to the upregulation of transposons, but also to delocalization of Piwi, Aub and Ago3, key factors in the piRNA biosynthesis pathway.
Sgf11 interacts with the cap-binding protein 80 (Cbp80) component of the cap-binding complex, and that Cbp80 knockdown interferes with Sgf11 recruitment on the hsp70 promoter.
Study proposes the existence of an alternative cap-binding complex involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis.
Results suggest that rev protein, HIV-1 (Rev) regulates the association of nuclear cap-binding protein NCBP 80 kDa subunit (CBP80) and eukaryotic translation initiation factor 4A1 (eIF4AI) with the unspliced mRNA in the cytoplasm and the nucleus, respectively, during HIV-1 replication.
down-regulation of CTIF using a small interfering RNA causes a redistribution of CBP80 from polysome fractions to subpolysome fractions, without significant consequence to eIF4E distribution
Cellular processes by which CBP80-CBP20 -bound messenger ribonucleoproteins (mRNPs) are remodeled to eIF4E-bound mRNPs, are overviewed.
Viral mRNA associates with the influenza virus A NS1 and the cellular NCBP1 of the nuclear cap-binding complex.
UPF1 binds PTC-containing mRNA more efficiently than the corresponding PTC-free mRNA in a way that is promoted by the UPF1-CBP80 interaction.
crystal structure at 2.1 A resolution of CBP20 and CBP80 bound to an m(7)GpppG cap analogue
Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
The organization of the CBP80-CBP20 complex suggests how the activity of eIF4G in translation initiation could be regulated through a dynamic network of overlapping intra- and intermolecular interactions.
During nonsense-mediated mRNA decay, CBP80 interacts with Upf1 and promotes the interaction of Upf1 with Upf2 but not with Stau1.
Association of CBC with PARN might have importance in the regulated recruitment of PARN to the nonsense-mediated decay pathway during the pioneer round of translation.
We show that NELF interacts with the nuclear cap binding complex (CBC), a heterodimeric, multifunctional factor that plays important roles in several mRNA processing steps, and the two factors together participate in the 3' end processing of histone mRNAs
The authors could distinguish two tyrosines, Y43 and Y20, in stabilization of the cap inside the cap-binding complex binding pocket.
a new MIF4G domain-containing protein, CTIF (CBP80/20-dependent translation initiation factor) that interacts directly with CBP80 and is part of the CBP80/20-dependent translation initiation complex
resolution X-ray structure for a cap-binding complex (CBC)-importin-alpha complex that provides a detailed picture for how importin-alpha binds to the CBP80 subunit of the CBC.
the identification of new genes involved in ABA-dependent abiotic stresses using Arabidopsis suppressor mutants of abh1 hypersensitivity to ABA during seed germination.
Data suggest that CBP20 and CBP80 (ABH1) have synergistic roles during the salt stress response.
SERRATE, CAP BINDING PROTEIN20 (CBP20), and CBP80 are regulators of lincRNA expression and biogenesis. RT-PCR experiments confirmed these three proteins are also needed for splicing of a small group of intron-containing lincRNAs.
This intron suppression of transgene silencing requires efficient intron splicing and is dependent on ABH1.
ABH1 (CBP80) encodes a large subunit of CBC (CAP BINDING COMPLEX) and the abh1 mutant is drought-tolerant and hypersensitive to ABA during seed germination.
The cbp80(abh1) and cbp20/80 mutants had many more changes in alternative splicing in common than did cbp20 and cbp20/80 suggesting that CBP80 plays a more significant role in alternative splicing than CBP20.
Abh1 lesion affects several developmental processes, perhaps because the processing of certain mRNAs.
CBP20 and CBP80 function in miRNA biogenesis by binding to pri-miRNA transcripts, and are stabilized by ABA by a post-translational mechanism.
AtCBP80 is required for the stability of AtCBP20 in the plant cell.
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay.
, Cap-binding protein 80
, nuclear cap-binding protein subunit 1
, NCBP 80 kDa subunit
, 80 kDa nuclear cap-binding protein
, nuclear cap-binding protein subunit 1-B
, nuclear cap binding protein subunit 1, 80kDa
, nuclear cap-binding protein subunit 1-like
, nuclear cap-binding protein subunit 1-A