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Full name:: Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Proteins (NPM1)

On www.antibodies-online.com are 24 Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) Proteins from 10 different suppliers available. Additionally we are shipping Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Antibodies (410) and Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Kits (11) and many more products for this protein. A total of 459 Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) products are currently listed.

Synonyms:: B23, B23NP, CG7917, Crp1, Dmel\\CG7917, dNLP, dNLP-S, NO38, Npm, npm4, p22

list all proteins	Gene Name	GeneID	UniProt
	NPM1	4869	P06748
	NPM1	25498	P13084
	NPM1	18148	Q61937
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Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Proteins (NPM1) by Origin

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Top referenced Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Proteins

Human NPM1 Protein expressed in Wheat germ - ABIN1312882 : Xu, Fang, Dhar, St Clair, Kasarskis, St Clair: The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene. in The Journal of biological chemistry 2007 (PubMed)
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Human Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) interaction partners

Nucleoplasmic translocation of NPM1 is a prerequisite for stress-induced activation of p53 (show TP53 Proteins).
NPM1 gene B type mutation enhanced the proliferation and invasion of THP-1 AML (show RUNX1 Proteins) cells through the regulation of TIMP-2 (show TIMP2 Proteins), MMP-2 (show MMP2 Proteins), Ang-1 (show ANGPT1 Proteins), c-myc (show MYC Proteins) and CCND1 (show CCND1 Proteins)
In this study, FLT3 (show FLT3 Proteins) and NPM1 mutations were evaluated in adult Iranian patients with de novo cytogenetically normal acute myeloid leukemia (show BCL11A Proteins) and its correlations with clinical and laboratory parameters were also assessed.
These observations demonstrated that the expression and localization of NPM affected the homeostatic balance of oxidative stress in tumor cells via PRDX6 (show PRDX6 Proteins) protein. The regulation axis of NPM/PRDX/ROS (show ROS1 Proteins) may provide a novel therapeutic target for cancer treatment.
ese results enhance our understanding of the molecular mechanisms that govern nucleoli formation by demonstrating that PPM1D regulates nucleolar formation by regulating NPM phosphorylation status through a novel signalling pathway, PPM1D-CDC25C-CDK1-PLK1
Data suggest that the direct interaction of several regions of nucleophosmin 1 (NPM1) C-terminal domain (CTD) with cellular membranes could be implicated in diseases where NPM1 is mutated and/or where its overexpression is cytoxic.
Mechanically, mutant NPM1 interacted with PML (show PML Proteins) and mediated its delocalization as well as stabilization contributing to elevated autophagic activity and leukemic cell survival in vitro.
Mutation analysis in NPM1 in acute myeloid leukemia (show BCL11A Proteins).
We conclude that the degradation of NPM1 and HEXIM1 (show HEXIM1 Proteins) through autophagy in certain AML (show RUNX1 Proteins) subsets contributes to the activation of the BET pathway in these cells.
miR (show MLXIP Proteins)-10b exerts its effects by repressing the translation of KLF4 (show KLF4 Proteins) and that NPM1-mA inhibits myeloid differentiation through the miR (show MLXIP Proteins)-10b/KLF4 (show KLF4 Proteins) axis.

Cow (Bovine) Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) interaction partners

Depletion of B23 expression inhibits virus production by BIV-infected cells, indicating that B23 plays an important role in BIV replication.
Results suggest that some polymorphisms in NPM1 are associated with body weight at some ages and may be used as candidates for marker-assisted selection and management in beef cattle breeding programmes.
The NPM1 gene is a candidate gene for growth traits in cattle.

Mouse (Murine) Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) interaction partners

In the current study, we demonstrate the existence of a negative feedback loop through which an increased B23 expression suppresses ERalpha (show ESR1 Proteins). Because suppression of ERalpha (show ESR1 Proteins) expression is a late event during estrogen-dependent endometrial tumorigenesis, the inhibition of nucleophisminmay represent a strategy to promote ERalpha (show ESR1 Proteins) re-expression that ultimately restores tumor sensitivity to hormonal therapy
molecular complementarity underlies the higher frequency and significantly worse prognosis associated with NPM1c/FLT3 (show FLT3 Proteins)-internal tandem duplications vs NPM1 (show GJA1 Proteins)/NRAS (show NRAS Proteins)-G12D-mutant acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) and functionally confirm the role of HOXA genes in NPM1c-driven AML (show RUNX1 Proteins).
NPM1 (show GJA1 Proteins)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (show CASP2 Proteins) activation cascade.
NPM1 (show GJA1 Proteins) knockdown decreased NF-kappaB (show NFKB1 Proteins)-mediated transcription of selected target genes by decreasing the recruitment of NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) to the gene promoters.
study suggests that although neurons need NPM1 (show GJA1 Proteins) for survival, an increase in its expression beyond physiological levels and its translocation to the cytoplasm leads to death through abortive cell cycle induction.
The levels of B23 expression are directly regulated by EGR1 (show EGR1 Proteins).
IDH2 (show IDH2 Proteins) and NPM1 (show GJA1 Proteins) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Proteins) stem-like cells.
Lrrc34, a novel nucleolar protein (show MCRS1 Proteins), interacts with npm1 (show GJA1 Proteins) and ncl (show NCL Proteins) and has an impact on pluripotent stem cells
a function of NPM1 (show GJA1 Proteins) in the spatial organization of nucleolus-associated heterochromatin through DNA methyltransferase (show DNMT1 Proteins) DNMT3A (show DNMT3A Proteins)
The data presented here support a novel role for NPM1 (show GJA1 Proteins) as a multilevel modulator of the base excision repair pathway.

Fruit Fly (Drosophila melanogaster) Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) interaction partners

NLP is essential for the positioning of centromeres during cell division in Drosophila.

Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) Protein Profile

Protein Summary

This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1)

nucleophosmin 1 (NPM1)
nucleophosmin 1b (npm1b)
Nucleophosmin (npm)
nucleophosmin (nucleolar phosphoprotein B23, numatrin) L homeolog (npm1.L)
nucleophosmin (NPM1)
nucleophosmin 1 (Npm1)
nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1)
Nucleoplasmin (Nlp)

B23 protein
B23NP protein
CG7917 protein
Crp1 protein
Dmel\\CG7917 protein
dNLP protein
dNLP-S protein
NO38 protein
Npm protein
npm4 protein
p22 protein

Protein level used designations for NPM1

nucleophosmin , nucleophosmin/nucleoplasmin, 4 , Nucleophosmin , nucleolar protein NO38 , nucleophosmin/nucleoplasmin family, member 1 , NPM , nucleolar phosphoprotein B23 , nucleoplasmin , numatrin , nucleolar protein B23.1 , nucleophosmin 1 , CG7917-PA , CG7917-PB , Nlp-PA , Nlp-PB , Nucleoplasmin-like , chromatin decondensation protein 1 , nucleoplasmin-1

GENE ID	SPECIES
100059112	Equus caballus
553507	Danio rerio
100195119	Salmo salar
4869	Homo sapiens
379194	Xenopus laevis
396203	Gallus gallus
25498	Rattus norvegicus
479292	Canis lupus familiaris
614028	Bos taurus
100328693	Oryctolagus cuniculus
740704	Pan troglodytes
18148	Mus musculus
100525313	Sus scrofa
43560	Drosophila melanogaster

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Show all Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Proteins (NPM1) with Pubmed References