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Human NPM1 Protein expressed in Wheat germ - ABIN1312882
Xu, Fang, Dhar, St Clair, Kasarskis, St Clair: The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene. in The Journal of biological chemistry 2007
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Studies indicate that nucleophosmin 1 (NPM1) has been considered as a promising target for the treatment of both haematologic and solid malignancies.
Work identifies the TP53 (show TP53 Proteins) tumor suppressor as a novel target through which NPM1-RARA (show RARA Proteins) impacts leukemogenesis.
These results suggested that relocation of NPM altered its interactional network and consequently disturbed the primary functions, including cell proliferation, adhesion, migration, and invasion. NPM plays a promotional role in cancer.
the consequence of mutations in NPM1 and possible mechanisms through which mutations lead to leukemogenesis (review0.
NPM1 mutation but not RUNX1 (show RUNX1 Proteins) mutation or multilineage dysplasia defines a prognostic subgroup within de novo acute myeloid leukemia (show BCL11A Proteins) lacking recurrent cytogenetic abnormalities
Nucleophosmin 1 (NPM1) mutations in chronic myelomonocytic leukemia and their prognostic relevance.
Multivariable analyses on time to relapse and OS revealed pre-transplant NPM1 MRD levels >1% as an independent prognostic factor for poor survival after allogeneic HSCT, whereas FLT3 (show FLT3 Proteins)-ITD had no impact. Notably, outcome of patients with pre-transplant NPM1 MRD positivity >1% was as poor as that of patients transplanted with RD.
Our results indicate that CD4 (show CD4 Proteins) expression and older age are adverse prognostic factors in wild-type NPM1, FLT3 (show FLT3 Proteins)-ITD-negative CN-AML (show RUNX1 Proteins).
NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (show CASP2 Proteins) activation cascade.
Data indicate that NPM-ALK was distributed in equal amounts between the cytoplasm and the nucleus.
Results suggest that some polymorphisms in NPM1 are associated with body weight at some ages and may be used as candidates for marker-assisted selection and management in beef cattle breeding programmes.
The NPM1 gene is a candidate gene for growth traits in cattle.
molecular complementarity underlies the higher frequency and significantly worse prognosis associated with NPM1c/FLT3 (show FLT3 Proteins)-internal tandem duplications vs NPM1 (show GJA1 Proteins)/NRAS (show NRAS Proteins)-G12D-mutant acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) and functionally confirm the role of HOXA genes in NPM1c-driven AML (show RUNX1 Proteins).
NPM1 (show GJA1 Proteins)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (show CASP2 Proteins) activation cascade.
NPM1 (show GJA1 Proteins) knockdown decreased NF-kappaB (show NFKB1 Proteins)-mediated transcription of selected target genes by decreasing the recruitment of NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) to the gene promoters.
study suggests that although neurons need NPM1 (show GJA1 Proteins) for survival, an increase in its expression beyond physiological levels and its translocation to the cytoplasm leads to death through abortive cell cycle induction.
The levels of B23 expression are directly regulated by EGR1 (show EGR1 Proteins).
IDH2 (show IDH2 Proteins) and NPM1 (show GJA1 Proteins) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Proteins) stem-like cells.
Lrrc34, a novel nucleolar protein (show MCRS1 Proteins), interacts with npm1 (show GJA1 Proteins) and ncl (show NCL Proteins) and has an impact on pluripotent stem cells
a function of NPM1 (show GJA1 Proteins) in the spatial organization of nucleolus-associated heterochromatin through DNA methyltransferase (show DNMT1 Proteins) DNMT3A (show DNMT3A Proteins)
The data presented here support a novel role for NPM1 (show GJA1 Proteins) as a multilevel modulator of the base excision repair pathway.
The mechanism of G-CSF's neuroprotection may be related in part to attenuating neuronal apoptosis by NPM1 (show GJA1 Proteins).
NLP is essential for the positioning of centromeres during cell division in Drosophila.
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
, nucleophosmin/nucleoplasmin, 4
, nucleolar protein NO38
, nucleophosmin/nucleoplasmin family, member 1
, nucleolar phosphoprotein B23
, nucleolar protein B23.1
, nucleophosmin 1
, chromatin decondensation protein 1