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Data show that the binding sites on adenine nucleotide translocator 1 (ANT1 (show SLC25A4 Antibodies)) have an affinity for cardiolipin (CL).
an essential role for PRPF6 in cancer via splicing of distinct growth-related gene products.
Our results identify PRPF6 as the sixth gene involved in pre-mRNA splicing and dominant RP, corroborating the hypothesis that deficiencies in the spliceosome play an important role in the molecular pathology of this disease.
The authors provide evidence that PRP6 and PRP31 (show PRPF31 Antibodies) are directly phosphorylated by human PRP4 kinase (PRP4K (show PRPF4B Antibodies)) concomitant with their incorporation into B complexes.
identification as a coactivator for the androgen receptor (show AR Antibodies) [p102 U5 small nuclear ribonucleoprotein particle-binding protein]
The interaction of CD2BP2 (show CD2BP2 Antibodies) with a tri (show VANGL2 Antibodies)-snRNP (show LSM2 Antibodies) bridging protein (Prp6), coupled with CD2BP2 (show CD2BP2 Antibodies)'s absence from the tri (show VANGL2 Antibodies)-snRNP (show LSM2 Antibodies), suggests it might function in tri (show VANGL2 Antibodies)-snRNP (show LSM2 Antibodies) assembly
C20orf14 may have a role in progression of lymphoma
The existence of these functional domains may further support the idea that ANT-1 (show SLC25A4 Antibodies) can function as an AR-AF-1 (show Psmd4 Antibodies)-specific coactivator while mediating a transcription-splicing coupling.
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.
, PRP6 pre-mRNA processing factor 6 homolog
, U5 snRNP-associated 102 kDa protein
, U5-102 kDa protein
, androgen receptor N-terminal domain transactivating protein-1
, androgen receptor N-terminal domain-transactivating protein 1
, p102 U5 small nuclear ribonucleoprotein particle-binding protein
, pre-mRNA-processing factor 6
, putative mitochondrial outer membrane protein import receptor
, PRP6 pre-mRNA splicing factor 6 homolog