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Human Polyclonal PTBP2 Primary Antibody for ELISA, WB - ABIN566177
Rolland, Evrard, Guitton, Lavigne, Calvel, Couvet, Jégou, Pineau: Two-dimensional fluorescence difference gel electrophoresis analysis of spermatogenesis in the rat. in Journal of proteome research 2007
Show all 6 Pubmed References
Human Monoclonal PTBP2 Primary Antibody for ELISA, WB - ABIN566178
Xue, Zhou, Wu, Zhu, Ji, Kwon, Zhang, Yeo, Black, Sun, Fu, Zhang: Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. in Molecular cell 2010
Show all 2 Pubmed References
Human Polyclonal PTBP2 Primary Antibody for ELISA - ABIN262285
Boutz, Stoilov, Li, Lin, Chawla, Ostrow, Shiue, Ares, Black: A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. in Genes & development 2007
Cow (Bovine) Polyclonal PTBP2 Primary Antibody for WB - ABIN2776545
Tateiwa, Gotoh, Ichikawa, Kikuchi, Yoshimura: Molecular cloning and characterization of human PTB-like protein: a possible retinal autoantigen of cancer-associated retinopathy. in Journal of neuroimmunology 2001
the study revealed that PTBP1 (show PTBP1 Antibodies) facilitates colorectal cancer migration and invasion activities by inclusion of cortactin (show CTTN Antibodies) exon 11
Results showed the expression level of PTBP1 (show PTBP1 Antibodies) were increased in bladder cancer (BC) patients and that its expression is negatively regulated by MIR (show MLXIP Antibodies)-145.
PTBP1 (show PTBP1 Antibodies) is a novel regulator of MCL1 (show MCL1 Antibodies) mRNA by which it controls apoptotic response to antitubulin chemotherapeutics.
PTB (show PTBP1 Antibodies) interacts specifically with 3'UTR (show UTS2R Antibodies) of p53 (show TP53 Antibodies) mRNA and positively regulates expression of p53 (show TP53 Antibodies) isoforms. PTB (show PTBP1 Antibodies) showed some overlapping binding regions in the p53 (show TP53 Antibodies) 3'UTR (show UTS2R Antibodies) with miR (show MLXIP Antibodies)-1285. Knockdown of miR (show MLXIP Antibodies)-1285 as well as expression of p53 (show TP53 Antibodies) 3'UTR (show UTS2R Antibodies) with mutated miR (show MLXIP Antibodies)-1285 binding sites resulted in enhanced association of PTB (show PTBP1 Antibodies) with the 3'UTR (show UTS2R Antibodies), which provides mechanistic insights of this interplay.
It has been established that PTBP1 (show PTBP1 Antibodies) and PTBP2 are members of a family of cryptic exon repressors.
These results demonstrate that during early stages of splicing, exon RNP (show RNPC3 Antibodies) complexes are highly dynamic with many proteins failing to bind during PTBP1 (show PTBP1 Antibodies) arrest.
Studied interactions of polypyrimidine tract-binding protein (show PTBP1 Antibodies) (PTBP1 (show PTBP1 Antibodies)), pyruvate kinase M2 (PKM2 (show PKM2 Antibodies)), and STAT3 (signal transducer and activator of transcription 3 (show STAT3 Antibodies)) in oncogenesis of anaplastic large cell lymphoma (ALCL). Results show that in ALCL cells, PTBP1 (show PTBP1 Antibodies) is crucial for PKM2 (show PKM2 Antibodies) phosphorylation of STAT3 (show STAT3 Antibodies) in the nucleus.
Expression of ATG10 (show ATG10 Antibodies) negatively regulated by PTBP1 (show PTBP1 Antibodies) and is associated with metastasis of colorectal cancer cells.
Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm.
follow-up molecular analyses of one splicing factor (show SLU7 Antibodies) PTBP1 (show PTBP1 Antibodies) revealed its impact on disease-associated splicing patterns in Huntington's disease (HD). Collectively, our data provide genomic evidence for widespread splicing dysregulation in HD brains, and suggest the role of aberrant alternative splicing in the pathogenesis of HD
splicing regulation by Ptbp2 is critical for germ cell communication with Sertoli cells
In round spermatids, MRG15 (show MORF4L1 Antibodies) colocalizes with splicing factors PTBP1 (show PTBP1 Antibodies) and PTBP2 at H3K36me3 sites between the exons and single intron of transition nuclear protein (show HEMGN Antibodies) 2 (Tnp2 (show TNP2 Antibodies)). Thus, our results reveal that MRG15 (show MORF4L1 Antibodies) is essential for pre-mRNA splicing during spermatogenesis and that epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorder
This knockin Ptbp1 (show PTBP1 Antibodies) rescued a forebrain-specific, but not a pan (show SUPT6H Antibodies)-neuronal, Ptbp2 knockout, demonstrating both redundant and distinct roles for the proteins. Many developmentally regulated exons exhibited different sensitivities to PTBP1 (show PTBP1 Antibodies) and PTBP2.
Ptbp2 is an essential factor in heat stress-induced sperm cell injury and non-obstructive azoospermia.
Ptbp2 ablation results in germ cell loss due to increased apoptosis of meiotic spermatocytes and postmeiotic arrest of spermatid differentiation.
These results define a new genetic regulatory program, where PTBP2 acts to temporarily repress expression of adult protein isoforms until the final maturation of the neuron.
Thus, Ptbp2 inhibition of a discrete set of adult neuronal exons underlies early brain development prior to neuronal differentiation and is essential for postnatal survival.
The expression of PSD-95 (show DLG4 Antibodies) during early neural development is controlled at the RNA level by two PTB (show PTBP1 Antibodies) proteins whose sequential downregulation is necessary for synapse maturation.
The present study provides evidence that alternative neuronal nPTB and Fox-1 (show A2BP1 Antibodies)/Fox-2 (show RBM9 Antibodies) isoforms are also produced in lenses
Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 (show CACNA1C Antibodies) calcium channel transcript by polypyrimidine tract-binding protein (show PTBP1 Antibodies).
Two stretches of polypyrimidine tracts designated PPT1 and PPT2 which influence the IRES activity of cx55.5 protein were identified; deletion of PPT2 results in a complete loss of the IRES activity
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
, neural polypyrimidine tract binding protein
, neural polypyrimidine tract-binding protein
, neurally-enriched homolog of PTB
, polypyrimidine tract-binding protein 2
, splicing regulator
, 57 kDa RNA-binding protein PPTB-1
, RNA-binding protein
, heterogeneous nuclear ribonucleoprotein I
, heterogeneous nuclear ribonucleoprotein polypeptide I
, hnRNP I
, polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
, polypyrimidine tract-binding protein 1
, RRM-type RNA-binding protein brPTB
, brain-enriched PTB
, brain-enriched polypyrimidine tract-binding protein
, polypyrimidine tract binding protein 2
, polypyrimidine tract-binding protein 2-like