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Study findings show that the LRP/LR receptor is critically implicated in apoptosis and that LRP/LR down-regulation induces apoptosis in early and late stage colorectal cancer cells through both apoptotic pathways.
the work revealed that these lysine mutations still appear to be important and can impact the fate and function of 37 LR, by impairing half-life and steady state pre-mRNA levels. These results suggest that the Lys residues within putative SUMO motifs of 37 LR are important for 37 LR function.
Mutations in RPSA exons can affect the translated or untranslated regions and can underlie Isolated congenital asplenia with complete or incomplete penetrance.
The binding of laminin-1 to 67LR causes initial signaling through PKA and Epac, which causes the internalization of 67LR, along with signaling enzymes, such as adenylyl cyclase, into early endosomes. This causes sustained signaling for protection against neuronal cell death induced by serum withdrawal.
We suggest that PrP(C) and its interactor, LR/37/67 kDa, could be potential therapeutic targets for schwannomas and other Merlin-deficient tumours.
Our results suggest that hypoxia-elicited c-Jun/activator protein 1 regulates 37-kDa laminin receptor precursor expression, which modulates migration and invasion of lung adenocarcinoma cells
Increased LRP levels correlate with the increased invasive and adhesive potential in early and late stage melanoma cells.
A polysaccharide from Pinellia ternata inhibits cell proliferation and metastasis in human cholangiocarcinoma cells by targeting of Cdc42 and 67kDa Laminin Receptor
67LR plays a considerable role in the development of colon cancer multidrug resistance
37LRP regulates the metastasis of glioma cells in vitro and tumor growth in vivo.
Higher molecular weight Rpsa requires sumoylation to form.
Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity
High expression level of the laminin receptor is associated with Breast and Oesophageal Cancer.
Report discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasivness.
LR1 contributes to hypoxia-induced migration and invasion of trophoblast cells at least partly by mediating MMP-9
Mutations in the gene RPSA, which encodes ribosomal protein SA, cause more than half of the cases of isolated congenital asplenia. These disease-causing mutations lead to haploinsufficiency of RPSA. Review.
analysis of the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis
Studies indicate that the expression of 37/67-kDa immature laminin receptor protein (iLRP)iLRP in the rodent and human fetus is phase specific
Suggest role for 67LR/mitogen activated protein kinase/DUSP pathway in influencing glioma cell proliferation.
a biological marker in distinguishing squamous cell carcinoma: from adenocarcinoma, neuroendocrine carcinomas, and malignant mesothelioma
High 67-kDa laminin receptor expression is associated with obesity-induced inflammation.
Studies indicate that the expression of 37/67-kDa immature laminin receptor protein (iLRP)iLRP in the rodent and human fetus is phase specific.
Results indicate that MGr1-Ag/37LRP contributes to laminin-mediated cell adhesion-mediated drug resistance in gastric cancer cells.
a high plasticity of RPSA, which could be important for its multiple cellular localizations and functional interactions
Laminin receptor activation inhibits endothelial TF expression by impairing JNK phosphorylation
protective role of TGF-beta1-dependent up-regulation of the 37/67 LR in cardiomyocytes in cardiac remodelling with increased laminin expression
Reduced expression of the TLR4 signaling pathway involves both the 67-kDa laminin receptor and Toll-interacting protein Tollip, leading to consequent inflammatory responses.
laminin receptor precursor protein interacts with doppel
34/67 laminin receptor, carries stage-specific embryonic antigen-4 epitope defined by monoclonal antibody Raft.2
An N-terminally truncated laminin receptor mutant encompassing the extracellular domain reduces the binding of recombinant cellular huPrP to mouse neuroblastoma cells,and interferes with the PrP(Sc) propagation.
LamR plays a role in transduction by three other closely related serotypes (adeno-associated virus serotype 2 (AAV2), -3, and -9)
both eEF1A and MYPT1 have roles in EGCG signaling for cancer prevention through 67LR
The interactions of prion protein (PrP) and laminin receptor (LRP/LR) are not restricted to the cell surface but occur also in intracellular compartments suggesting a putative role of LRP/LR in the trafficking of PrP molecules.
Green tea (-)-epigallocatechin gallate inhibits insulin stimulation of 3T3-L1 preadipocyte mitogenesis via the 67-kDa laminin receptor pathway.
disruption or modulation of the interaction of bacterial adhesins with laminin receptor might engender unexpectedly broad protection against bacterial meningitis and may provide a therapeutic target for the prevention and treatment of disease
These results indicate that LamR is a cellular attachment receptor for classical Swine Fever virus.
Dengue virus serotypes 1, 2 and 3 all interact with the 37 kDa/67 kDa laminin receptor (LAMR1), a common non-integrin surface protein on many cell types.
isolated a ribosomal protein SA cDNA that consists of 1064 bp with an open reading frame of 885 bp encoding a 295 aa protein
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
37 kDa laminin receptor
, 37/67 kDa laminin receptor
, 67 kDa laminin receptor
, Laminin receptor 1
, Laminin-binding protein precursor p40
, ribosomal protein SA
, 40S ribosomal protein SA
, laminin-binding protein precursor p40
, colon carcinoma laminin-binding protein
, laminin receptor 1 (67kD, ribosomal protein SA)
, multidrug resistance-associated protein MGr1-Ag
, 37 kDa oncofetal antigen
, P40-3, functional
, P40-8, functional
, laminin receptor 1 (ribosomal protein SA)
, 37kD Laminin receptor
, laminin receptor 1
, laminin receptor 1 (ribosomal protein SA, 67 kDA)
, ribosomal protein SA pseudogene
, laminin receptor