Browse our SNRPE Proteins (SNRPE)

Full name:: Small Nuclear Ribonucleoprotein Polypeptide E Proteins (SNRPE)

On www.antibodies-online.com are 12 Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE) Proteins from 7 different suppliers available. Additionally we are shipping SNRPE Antibodies (160) and SNRPE Kits (11) and many more products for this protein. A total of 197 SNRPE products are currently listed.

Synonyms:: 9930012E13Rik, AA120551, AA387315, AA473386, AL022645, b-raf, B-RAF1, Braf-2, BRAF1, Braf2, C76690, C87398, C230098H17, D6Ertd631e, HYPT11, NS7, RAFB1, sm-e, SmE, snRNP-E, zgc:56682

list all proteins	Gene Name	GeneID	UniProt
	SNRPE	673	P15056
	SNRPE	109880	P28028
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Human Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE) interaction partners

BRAF (show BRAF Proteins) mutations more frequently affected individuals younger than 61 with phototype II. In contrast, NRAS (show NRAS Proteins) mutations were more frequent in phototype III cases. Mutations of both genes were more frequent in cases with satellitosis in the first melanoma, and in cases with ulceration in the subsequent lesions.
Identification of KRAS/NRAS/BRAF (show BRAF Proteins) mutation status is crucial to predict the therapeutic effect and determine individual therapeutic strategies for patients with colorectal cancer.
we did not observe GNAS (show GNAS Proteins) or BRAF (show BRAF Proteins) mutations in urachal adenocarcinomas
Study finds infrequent BRAF (show BRAF Proteins) alterations but enriched FGFR (show FGFR2 Proteins) alterations in adults as compared with that reported in pediatric pilocytic astrocytomas. In addition, coexistent BRAF (show BRAF Proteins) and FGFR (show FGFR2 Proteins) alterations and a significant association of FGFR (show FGFR2 Proteins) alterations with age and tumor location were noted.
a low frequency of BRAF or KRAS mutation in Chinese patients with low-grade serous carcinoma of the ovary
genetic association studies in population in China: Data suggest that, in patients with unilateral papillary thyroid carcinoma, a mutation in BRAF (show BRAF Proteins) (V600E) plus multi-focality are both independently and synergically associated with CLNM (central lymph node metastasis) in the population studied.
RHEB (show RHEB Proteins) Y35N expressing cells undergo cancer transformation due to decreased interaction between RHEB (show RHEB Proteins) and BRAF (show BRAF Proteins) resulting in overactive RAF (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) signaling. Taken together with the previously established function of RHEB (show RHEB Proteins) to activate mTORC1 signaling, it appears that RHEB (show RHEB Proteins) performs a dual function; one is to suppress the RAF (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) signaling and the other is to activate mTORC1 signaling.
The MLH1 (show MLH1 Proteins)-93 AA genotype is significantly associated with promoter hypermethylation and MLH1 (show MLH1 Proteins) loss in the context of Sessile serrated adenoma of dysplasia. BRAF (show BRAF Proteins) mutant microsatellite stable colorectal cancers with the AA genotype most likely arise in traditional serrated adenomas since the A allele does not predispose to methylation in this context.
Knowing the mutation status of KRAS, BRAF (show BRAF Proteins) or PIK3CA (show PIK3CA Proteins) in stage II colorectal cancer can significantly improve the accuracy of prognoses.
Mutated Liquid-based FNAs BRAF (show BRAF Proteins), N/HRAS (show HRAS Proteins) and TERT (show TERT Proteins) mutations were significantly associated with malignancy regardless of the cytological classification

Mouse (Murine) Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE) interaction partners

mosaic expression of BRAF (show BRAF Proteins)(V600E) in mouse erythro-myeloid progenitors results in clonal expansion of tissue-resident macrophages and a severe late-onset neurodegenerative disorder
CDX2 (show CDX2 Proteins)(Null)/BRAF (show BRAF Proteins)(V600E) expression in adult mouse intestinal epithelium led to serrated morphology tumors (including carcinomas) and BRAF (show BRAF Proteins)(V600E) potently interacted with CDX2 (show CDX2 Proteins) silencing to alter gene expression. Like human serrated lesions, CDX2 (show CDX2 Proteins)(Null)/BRAF (show BRAF Proteins)(V600E)-mutant epithelium expressed gastric markers.
expression of an endogenous Braf (show BRAF Proteins)(D631A) kinase-inactive isoform in mice (corresponding to the human BRAF (show BRAF Proteins)(D594A) mutation) triggers lung adenocarcinoma in vivo, indicating that BRAF (show BRAF Proteins)-inactivating mutations are initiating events in lung oncogenesis
TTM (show SLITRK1 Proteins) reduces copper levels and MAPK (show MAPK1 Proteins) signaling, thereby inhibiting BRAF (show BRAF Proteins)(V600E)-driven melanoma tumor growth.
BRAF (show BRAF Proteins) and ROKalpha (show ROCK2 Proteins) form independent RAF1 (show RAF1 Proteins) complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (show EGF Proteins)).
Braf (show BRAF Proteins)(V600E) expression, coupled with simultaneous p53 (show TP53 Proteins) ablation, permits bypass of senescence and progression to lung adenocarcinoma.
These results provide support for the role of BRAF (show BRAF Proteins)(V600E) in metastasis.
Mechanistically, BRAF (show BRAF Proteins) and RAF1 (show RAF1 Proteins) operate independently to balance MAPK (show MAPK1 Proteins) signaling: BRAF (show BRAF Proteins) promotes ERK (show EPHB2 Proteins) activation, while RAF1 (show RAF1 Proteins) dims stress kinase activation.
Mass spectrometry based screening for potential interaction partners revealed that BRAF (show BRAF Proteins) interacts and phosphorylates PAX3 (show PAX3 Proteins).
Using a conditional allele for Braf (show BRAF Proteins)(V600E) , a mutation observed in clinical cases of GIST, authors observed that Braf (show BRAF Proteins)(V600E) activation was sufficient to drive ICC hyperplasia but not GIST tumorigenesis.

SNRPE Protein Profile

Protein Summary

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

Alternative names and synonyms associated with SNRPE

B-Raf proto-oncogene, serine/threonine kinase (BRAF)
small nuclear ribonucleoprotein polypeptide E (SNRPE)
small nuclear ribonucleoprotein polypeptide E L homeolog (snrpe.L)
Braf transforming gene (Braf)
small nuclear ribonucleoprotein E (Snrpe)
small nuclear ribonucleoprotein polypeptide E (snrpe)
small nuclear ribonucleoprotein polypeptide E (Snrpe)

9930012E13Rik protein
AA120551 protein
AA387315 protein
AA473386 protein
AL022645 protein
b-raf protein
B-RAF1 protein
Braf-2 protein
BRAF1 protein
Braf2 protein
C76690 protein
C87398 protein
C230098H17 protein
D6Ertd631e protein
HYPT11 protein
NS7 protein
RAFB1 protein
sm-e protein
SmE protein
snRNP-E protein
zgc:56682 protein

Protein level used designations for SNRPE

94 kDa B-raf protein , B-Raf proto-oncogene serine/threonine-protein kinase (p94) , murine sarcoma viral (v-raf) oncogene homolog B1 , proto-oncogene B-Raf , serine/threonine-protein kinase B-raf , v-raf murine sarcoma viral oncogene homolog B1 , sm protein E , small nuclear ribonucleoprotein E , snRNP-E , small nuclear ribonucleoprotein polypeptide E , SmE protein , sm-E , smE

GENE ID	SPECIES
673	Homo sapiens
6635	Homo sapiens
443996	Xenopus laevis
478934	Canis lupus familiaris
741566	Pan troglodytes
109880	Mus musculus
396180	Gallus gallus
100038330	Sus scrofa
531493	Bos taurus
20643	Mus musculus
393979	Danio rerio
100724868	Cavia porcellus

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