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Full name:: Dihydropyrimidine Dehydrogenase Proteins (DPYD)

On www.antibodies-online.com are 8 Dihydropyrimidine Dehydrogenase (DPYD) Proteins from 5 different suppliers available. Additionally we are shipping DPYD Antibodies (62) and DPYD Kits (53) and many more products for this protein. A total of 125 DPYD products are currently listed.

Synonyms:: 14.t00017, AI315208, DDBDRAFT_0189681, DDBDRAFT_0231100, DDB_0189681, DDB_0231100, dhp, dhpdhase, dpd, dpyd, E330028L06Rik, zgc:77205

list all proteins	Gene Name	GeneID	UniProt
Rat DPYD	DPYD	81656	O89000
	DPYD	99586	Q8CHR6
	DPYD	1806	Q12882
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DPYD Proteins (DPYD) by Origin

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Relevant Pathways for DPYD Proteins

Ribonucleoside Biosynthetic Process

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Pig (Porcine) Dihydropyrimidine Dehydrogenase (DPYD) interaction partners

Data show that dihydropyrimidine dehydrogenase residue H673 is required for active site closure, while S670 is important for substrate recognition.

Mouse (Murine) Dihydropyrimidine Dehydrogenase (DPYD) interaction partners

DPD gene expression is regulated first at the mRNA level when the hepatocytes enter the cell cycle. There is little regulation at the translational level. Cell proliferation rate is influences the enzyme activity modification.

Human Dihydropyrimidine Dehydrogenase (DPYD) interaction partners

Results still showed UGT1A1 (show UGT1A1 Proteins)*6 and UGT1A1 (show UGT1A1 Proteins)*28 to be partially associated with irinotecan-induced toxicity and clinical response. An examination of more UGT1A (show UGT1A1 Proteins) loci, except for UGT1A1 (show UGT1A1 Proteins)*6 and UGT1A1 (show UGT1A1 Proteins)*28, was not helpful to improve the predictive value of irinotecan-based toxicity and efficacy. An examination of DPYD*5 assisted in the prediction of severe diarrhea.
The present study suggests that the SNP rs1801160 and the "IISt" haplotype in the DPYD gene may also have a role in colorectal cancer risk.
Low DPYD expression is associated with colorectal cancer.
*6 rs1801160 and *2A rs3918290 DPYD variant alleles were significantly associated with time to neutropenia in colon cancer.
Results have shown crosstalk among the EGFR (show EGFR Proteins) cascade and Sp1 (show PSG1 Proteins) and DPD expressions in EGFR (show EGFR Proteins) mutant non-small-cell lung cancer cell lines. EGF (show EGF Proteins)-induced Sp1 (show PSG1 Proteins) up-regulation resulted in both DPYD mRNA and DPD protein expressions.
Carriers of the rare allelic variants DPYD*2A, DPYD*13, and DPYD D949V are more likely to experience severe adverse reactions during fluoropyrimidine-based therapy.
Exploring an extended set of deleterious DPYD variants improves the performance of DPYD genotyping for predicting both grade 3-4 and grade 4 toxicities (digestive and/or neurologic and/or hematotoxicities) related to capecitabine, as compared to conventional genotyping restricted to consensual variants *2A, *13 and D949V
Combined expression analyses of hENT1, TS, and DPD may predict long-term outcomes in patients with borderline resectable pancreatic cancer after neoadjuvant chemoradiotherapy
We demonstrated that real-time DPYD genotyping using TaqMan probes is cost effective in all fluoropyrimidine-based treatments
In pancreatic neuroendocrine neoplasms, biochemical response (p = 0.005) and high dihydropyrimidine-dehydrogenase expression (p = 0.018) were predictive markers of response to 5-FU-based chemotherapy. Thymidylate-Synthase (show TYMS Proteins) deficiency was an independent risk factor for shorter progression-free survival.

DPYD Protein Profile

Protein Summary

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with DPYD

dihydropyrimidine dehydrogenase (DPYD)
dihydropyrimidine dehydrogenase (Dpyd)
dihydropyrimidine dehydrogenase b (dpydb)
dihydropyrimidine dehydrogenase L homeolog (dpyd.L)
dihydropyrimidine dehydrogenase (EHI_012980)
dihydropyrimidine dehydrogenase [NADP(+)] (LOC5573038)
dihydropyrimidine dehydrogenase (EDI_044620)
dihydropyrimidine dehydrogenase (pyd1)

14.t00017 protein
AI315208 protein
DDBDRAFT_0189681 protein
DDBDRAFT_0231100 protein
DDB_0189681 protein
DDB_0231100 protein
dhp protein
dhpdhase protein
dpd protein
dpyd protein
E330028L06Rik protein
zgc:77205 protein

Protein level used designations for DPYD

DHPDHase , DPD , dihydropyrimidine dehydrogenase [NADP(+)] , dihydrothymine dehydrogenase , dihydrouracil dehydrogenase , dihydropyrimidine dehydrogenase

GENE ID	SPECIES
397109	Sus scrofa
100173131	Pongo abelii
457047	Pan troglodytes
429083	Gallus gallus
715672	Macaca mulatta
100057177	Equus caballus
479935	Canis lupus familiaris
281124	Bos taurus
81656	Rattus norvegicus
405829	Danio rerio
99586	Mus musculus
1806	Homo sapiens
447312	Xenopus laevis
3410647	Entamoeba histolytica HM-1:IMSS
5573038	Aedes aegypti
5882869	Entamoeba dispar SAW760
8616259	Dictyostelium discoideum AX4
100604410	Nomascus leucogenys
100727906	Cavia porcellus
100356889	Oryctolagus cuniculus
101109311	Ovis aries

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