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Human MTAP Protein expressed in Wheat germ - ABIN1311524
Yang, Gee, Gee, Zurita-Lopez, Khare, Clarke, Mamula: Lupus autoimmunity altered by cellular methylation metabolism. in Autoimmunity 2013
High MTAP expression is associated with prostate cancer.
Results indicate complex rearrangements involving CDKN2A locus and frequent occurrence of fusion transcripts involving methylthioadenosine phosphorylase (MTAP) and ANRIL genes.
The SNP rs7023954 of methylthioadenosine phosphorylase co-dominantly expressed alleles revealed no difference in the conversion rate of 5'-methylthioadenosine to adenine and 5-methylthioribose-1-phosphate, indicating that this known enzymatic activity does not modulate the tumor suppressive function of methylthioadenosine phosphorylase.
Data demonstrate that MTAP deficiency leads to accumulation of MTA (show DNMT1 Proteins) inducing deregulation of central cellular pathways that control cell fate and contributes to the onset of a proliferative and antiapoptotic phenotype in the liver.
methionine adenosyltransferase II alpha (MAT2A (show MAT2A Proteins)), and the arginine methyltransferase, PRMT5 (show PRMT5 Proteins), as vulnerable enzymes in cells with MTAP deletion.
MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors.
study to describe MTAP expression in a series of Pilocytic astrocytomas and relate it to the clinicopathological features of the patients; found MTAP expression is retained in Pilocytic astrocytomas and is not an outcome predictor for these tumors
MTAP deficiency was predictive of worse disease-specific survival and distant metastasis-free survival, suggesting its role in disease progression and as an independent prognostic biomarker of nasopharyngeal carcinoma
In the MTAP-deficient cases, the homozygous deletion of MTAP predicted adverse outcome. In MTAP-deficient cells, MTAP reexpression inhibited cell migration and invasion, proliferation and anchorage-independent colony formation and downregulated cyclin D1 (show CCND1 Proteins).
MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients.
Germline Mutations in Mtap is associated with lymphomagenesis.
MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB (show NFKB1 Proteins) activation and apoptosis in hepatic stellate cells.
Regulation of MTAP by reactive oxygen species might participate in the redox regulation of the methionine catabolic pathway in the liver
Studies show that Mtap is a tumor suppressor gene independent of CDKN2A and ARF.
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.
, MTA phosphorylase
, MeSAdo phosphorylase
, S-methyl-5'-thioadenosine phosphorylase
, methylthioadenosine phosphorylase
, methylthioadenosine phosphorylase L homeolog