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Full name:: Methylthioadenosine phosphorylase Proteins (MTAP)

On www.antibodies-online.com are 18 Methylthioadenosine phosphorylase (MTAP) Proteins from 7 different suppliers available. Additionally we are shipping MTAP Antibodies (61) and MTAP Kits (13) and many more products for this protein. A total of 95 MTAP products are currently listed.

Synonyms:: 1300019I21Rik, BDMF, c86fus, Cc1-6, DMSFH, DMSMFH, LGMBF, MSAP, mtap, MTAPase, zgc:66012

list all proteins	Gene Name	GeneID	UniProt
	MTAP	4507	Q13126
Rat MTAP	MTAP	298227
	MTAP	66902	Q9CQ65
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MTAP Proteins (MTAP) by Origin

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Relevant Pathways for MTAP Proteins

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Top referenced MTAP Proteins

Human MTAP Protein expressed in Wheat germ - ABIN1311524 : Yang, Gee, Gee, Zurita-Lopez, Khare, Clarke, Mamula: Lupus autoimmunity altered by cellular methylation metabolism. in Autoimmunity 2013 (PubMed)

More Proteins for MTAP Interaction Partners

Human Methylthioadenosine phosphorylase (MTAP) interaction partners

High MTAP expression is associated with prostate cancer.
Results indicate complex rearrangements involving CDKN2A locus and frequent occurrence of fusion transcripts involving methylthioadenosine phosphorylase (MTAP) and ANRIL genes.
The SNP rs7023954 of methylthioadenosine phosphorylase co-dominantly expressed alleles revealed no difference in the conversion rate of 5'-methylthioadenosine to adenine and 5-methylthioribose-1-phosphate, indicating that this known enzymatic activity does not modulate the tumor suppressive function of methylthioadenosine phosphorylase.
Data demonstrate that MTAP deficiency leads to accumulation of MTA (show DNMT1 Proteins) inducing deregulation of central cellular pathways that control cell fate and contributes to the onset of a proliferative and antiapoptotic phenotype in the liver.
methionine adenosyltransferase II alpha (MAT2A (show MAT2A Proteins)), and the arginine methyltransferase, PRMT5 (show PRMT5 Proteins), as vulnerable enzymes in cells with MTAP deletion.
MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors.
study to describe MTAP expression in a series of Pilocytic astrocytomas and relate it to the clinicopathological features of the patients; found MTAP expression is retained in Pilocytic astrocytomas and is not an outcome predictor for these tumors
MTAP deficiency was predictive of worse disease-specific survival and distant metastasis-free survival, suggesting its role in disease progression and as an independent prognostic biomarker of nasopharyngeal carcinoma
In the MTAP-deficient cases, the homozygous deletion of MTAP predicted adverse outcome. In MTAP-deficient cells, MTAP reexpression inhibited cell migration and invasion, proliferation and anchorage-independent colony formation and downregulated cyclin D1 (show CCND1 Proteins).
MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients.

Mouse (Murine) Methylthioadenosine phosphorylase (MTAP) interaction partners

Germline Mutations in Mtap is associated with lymphomagenesis.
Data demonstrate that MTAP deficiency leads to accumulation of MTA (show DNMT1 Proteins) inducing deregulation of central cellular pathways that control cell fate and contributes to the onset of a proliferative and antiapoptotic phenotype in the liver.
MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB (show NFKB1 Proteins) activation and apoptosis in hepatic stellate cells.
Regulation of MTAP by reactive oxygen species might participate in the redox regulation of the methionine catabolic pathway in the liver
Studies show that Mtap is a tumor suppressor gene independent of CDKN2A and ARF.

MTAP Protein Profile

Protein Summary

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.

Alternative names and synonyms associated with MTAP

methylthioadenosine phosphorylase (MTAP)
methylthioadenosine phosphorylase (Mtap)
methylthioadenosine phosphorylase (mtaP)
methylthioadenosine phosphorylase (MMAH_RS04260)
5'-methylthioadenosine phosphorylase (TAGG_RS05050)
methylthioadenosine phosphorylase (Toce_0364)
5'-methylthioadenosine phosphorylase (VDIS_RS03165)
methylthioadenosine phosphorylase (MFER_RS02485)
methylthioadenosine phosphorylase (Intca_0886)
5'-methylthioadenosine phosphorylase (DESMU_RS05370)
methylthioadenosine phosphorylase (Dester_1490)
6-oxopurine nucleoside phosphorylase (ARCVE_RS05445)
methylthioadenosine phosphorylase (Mahau_1873)
methylthioadenosine phosphorylase (MZHIL_RS01440)
methylthioadenosine phosphorylase (mtap)
methylthioadenosine phosphorylase L homeolog (mtap.L)

1300019I21Rik protein
BDMF protein
c86fus protein
Cc1-6 protein
DMSFH protein
DMSMFH protein
LGMBF protein
MSAP protein
mtap protein
MTAPase protein
zgc:66012 protein

Protein level used designations for MTAP

5'-methylthioadenosine phosphorylase , MTA phosphorylase , MTAPase , MeSAdo phosphorylase , S-methyl-5'-thioadenosine phosphorylase , methylthioadenosine phosphorylase , CG4802-like , methylthioadenosine phosphorylase L homeolog

GENE ID	SPECIES
4507	Homo sapiens
298227	Rattus norvegicus
3230190	Dehalococcoides ethenogenes 195
8983006	Methanohalophilus mahii DSM 5219
9166038	Thermosphaera aggregans DSM 11486
9509999	Thermosediminibacter oceani DSM 16646
9751569	Vulcanisaeta distributa DSM 14429
9962213	Methanothermus fervidus DSM 2088
10083682	Intrasporangium calvum DSM 43043
10153764	Desulfurococcus mucosus DSM 2162
10270747	Desulfurobacterium thermolithotrophum DSM 11699
10394208	Archaeoglobus veneficus SNP6
10608635	Mahella australiensis 50-1 BON
10821877	Methanosalsum zhilinae DSM 4017
66902	Mus musculus
709020	Macaca mulatta
782907	Bos taurus
393526	Danio rerio
100729773	Cavia porcellus
735090	Xenopus laevis
474729	Canis lupus familiaris

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Show all Methylthioadenosine phosphorylase Proteins (MTAP) with Pubmed References

Human Methylthioadenosine phosphorylase (MTAP) interaction partners

Mouse (Murine) Methylthioadenosine phosphorylase (MTAP) interaction partners

Protein Summary

Alternative names and synonyms associated with MTAP

Protein level used designations for MTAP