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Dog (Canine) Polyclonal PRTFDC1 Primary Antibody for WB - ABIN2773930
Suzuki, Imoto, Pimkhaokham, Nakagawa, Kamata, Kozaki, Amagasa, Inazawa: PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. in Oncogene 2007
We found evidence for PRTFDC1 as a potential novel PTSD gene, a finding that awaits further replication.
These results demonstrate that PRTFDC1 is a genetic modifier of HPRT (show HPRT1 Antibodies)-deficiency in the mouse.
The PRTFDC1 structure has been determined at 1.7 A resolution with bound GMP (show NT5C2 Antibodies). The overall structure and GMP (show NT5C2 Antibodies) binding mode are very similar to that observed for HPRT (show HPRT1 Antibodies).
epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis.
Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.
phosphoribosyl transferase domain containing 1
, phosphoribosyltransferase domain-containing protein 1
, hypoxanthine phosphoribosyltransferase
, HHGP protein