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Rpb1 CTD Products

(RNA Polymerase II CTD)


DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity). stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Recommended Rpb1 CTD Antibodies

Cat. No.
Reactivity Human, Mouse
Application ChIP, ICC, IF, WB
  • (5)
  • (4)
Cat. No. ABIN4889651
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ChIP-seq, ChIP, WB
  • (3)
  • (4)
Cat. No. ABIN2668520
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ChIP-seq, ChIP, WB
  • (4)
Cat. No. ABIN6972642
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Rpb1 CTD products

Cohen, Puget, Lin, Clouaire, Aguirrebengoa, Rocher, Pasero, Canitrot, Legube: "Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations." in: Nature communications, Vol. 9, Issue 1, pp. 533, (2018) (PubMed).

Varshney, Lombardi, Schweikert, Dunn, Suska, Cowling: "mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription." in: Cell reports, Vol. 23, Issue 5, pp. 1530-1542, (2018) (PubMed).

Young, Hillyer, Hokamp, Fitzpatrick, Konstantinov, Welty, Ness, Werner-Washburne, Fleming, Osley: "Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast." in: BMC genomics, Vol. 18, Issue 1, pp. 107, (2017) (PubMed).

Chung, Xu, Fuchs, Mund, Lange, Staege, Schubert, Bian, Dunkel, Eberharter, Regnard, Klinker, Meierhofer, Cozzuto, Winterpacht, Di Croce, Min, Will, Kinkley: "PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3." in: eLife, Vol. 5, (2016) (PubMed).

Harlen, Trotta, Smith, Mosaheb, Fuchs, Churchman: "Comprehensive RNA Polymerase II Interactomes Reveal Distinct and Varied Roles for Each Phospho-CTD Residue." in: Cell reports, Vol. 15, Issue 10, pp. 2147-2158, (2016) (PubMed).

Materne, Anandhakumar, Migeot, Soriano, Yague-Sanz, Hidalgo, Mignion, Quintales, Antequera, Hermand: "Promoter nucleosome dynamics regulated by signalling through the CTD code." in: eLife, Vol. 4, (2015) (PubMed).

Allepuz-Fuster, Martínez-Fernández, Garrido-Godino, Alonso-Aguado, Hanes, Navarro, Calvo: "Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation." in: Nucleic acids research, Vol. 42, Issue 22, pp. 13674-88, (2015) (PubMed).

Schubert, Weisshart: "Abundance and distribution of RNA polymerase II in Arabidopsis interphase nuclei." in: Journal of experimental botany, Vol. 66, Issue 6, pp. 1687-98, (2015) (PubMed).

Ramos, Wijetunga, McLellan, Suzuki, Greally: "DNA demethylation by 5-aza-2'-deoxycytidine is imprinted, targeted to euchromatin, and has limited transcriptional consequences." in: Epigenetics & chromatin, Vol. 8, pp. 11, (2015) (PubMed).

Catania, Pidoux, Allshire: "Sequence features and transcriptional stalling within centromere DNA promote establishment of CENP-A chromatin." in: PLoS genetics, Vol. 11, Issue 3, pp. e1004986, (2015) (PubMed).

Synonyms and alternative names related to Rpb1 CTD

RNA polymerase II 215kD subunit (RpII215), 5, 8WG16, CG1554, CTD, Dmel\\CG1554, dRPB1, dRpb1, H5, II, l(1)10Ca, l(1)DC912, l(1)DF912, l(1)G0040, l(1)L5, L5, POL, Pol-IIa, Pol II, PolII, pol II, polII, Pol II0[ser2], Pol II0[ser5], Pol IIa, Pol II CTD, Pol IIo, PolIIo, Pol IIo[Ser2], Pol IIo[ser2], Pol IIo[ser5], Pol II Ser5P, Pol II[ser2], RNAP, RNAP II, RNAPII, RNAPII0, RNAP II LS, RNApol2, RNA PolI 215, RNA Pol II, RNA PolII, RNA pol II, RNA polII, RNApolII, RNA Pol II CTD, RNA pol IIo, RPB1, Rpb1, RpII, RPII215, Rpll215, Ubl

Protein level used designations for Rpb1 CTD

  • CG1554-PA
  • Pol II CTD
  • Pol II large subunit
  • RNA Pol II
  • RNA polymerase II
  • RNA polymerase II large subunit
  • RNA polymerase IIo
  • RNA polymeraseII-215 kd subunit
  • RNA-polymerase II
  • RpII215-PA
  • Ultrabithorax-like
  • polymerase II CTD
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