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CD34(+) hematopoietic progenitors and granulocytes from patients with primary myelofibrosis showed decreased levels of ABI1 transcript as well as increased activity of Src family kinases , STAT3, and NF-kappaB.
The expression of ABI1 was suppressed by miR-181a/b, and ABI1 was validated as a direct target of miR-181a/b. miR-181a/b were significantly upregulated in aggressive neuroblastoma, which enhanced its tumorigenesis and progression by suppressing the expression of ABI1.
These studies demonstrate a requirement for human herpesvirus 5 pUL135 interactions with Abi-1 and CIN85 for regulation of EGFR and mechanistically link the regulation of EGFR to virus reactivation.
our findings indicated that ABI1 contributes to the development and progression of hepatocellular carcinoma (HCC) as an oncogene and may serve as a valuable prognostic marker for HCC patients.
these data indicate that HCV exploits host Abi1 protein via NS5A to modulate MEK/ERK signaling pathway for its own propagation.
Suggest that Abi1 acts as a tumor-promoting gene in epithelial ovarian cancer progression, which may lead to unfavorable prognosis.
These results indicate that the alpha4-Abi-1 signaling pathway may mediate acquisition of the drug-resistant phenotype of leukemic cells.
Our data indicate that phosphorylated Abi1 contributes to the invasive properties of colorectal cancer.
Abi1 is expressed at the invasive front of colorectal carcinomas and localizes to the leading edge of lamellipodia in cultured colorectal carcinoma cells.
Data indicate that Abi1 is activated by the c-Abl-Crk-associated substrate (CAS) pathway, and Abi1 reciprocally controls the activation of its upstream regulator c-Abl.
a possible role for Abi1 as a marker for early KRAS mutation in hyperplastic polyps
Breast tumors expressing high levels of Abi1 are significantly associated with early recurrence and worse survival on multivariate analysis.
Down-regulation of E3B1/ABI-1 expression in human carcinomas may play a critical role in tumor progression and in determining disease prognosis.
The phosphorylation and dephosphorylation cycle of VASP by the Abi-1-bridged mechanism regulates association of VASP with focal adhesions, which may regulate adhesion of Bcr-Abl-transformed leukaemic cells.
CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis
Expression of Abi1 is up-regulated in hepatocellular carcinoma tissues compared with corresponding para carcinomatous liver tissue, and is significantly correlated with tumor number, capsular formation, venous invasion, grade and prognosis.
Data show that disruption of phosphorylation sits Y398 and Y213 significantly weakens the binding of Abi-1 to c-Abl.
Study implicates that the integrity of SOS1/EPS8/ABI1 tri-complex is a determinant of ovarian cancer metastasis.
Downregulation of ABI1 expression in human gastric carcinoma may play a critical role in tumor progression and in determining patient prognosis.
Macropinocytosis is regulated by interactions between Abi1 pY213 and the C-terminal SH2 domain of p85-thereby linking Abl kinase signaling to p85-dependent regulation of macropinocytosis.
This study shows that bone marrow-specific deletion of Abi1 in a novel mouse model leads to development of an myeloproliferative neoplasms-like phenotype resembling human primary myelofibrosis. Abi1 loss resulted in a significant increase in the activity of the Src family kinases (SFKs), STAT3, and NF-kappaB signaling.
The expression of NESH/Abi-3 caused degradation of endogenous Abi-1, which led to the formation of a NESH/Abi-3-based WAVE2 complex.
sential role for Abi1 in embryonic survival and WAVE2 complex integrity
Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.
Abi1 (also known as E3b1) recruits PI3K, via p85, into a multimolecular signaling complex that includes Eps8 and Sos-1
Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins
Altogether these data identify a WAVE2-Abi1 complex crucial for the normal actin cytoskeleton reorganization and migration of macrophages in response to CSF-1.
c-Abl activates WAVE2 via tyrosine phosphorylation to promote actin remodeling in vivo; Abi-1 forms the crucial link between these two factors
These results show that the interaction between Abi-1 and betaPIX is involved in the formation of growth factor-induced membrane dorsal ruffles.
NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl.
The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading.
Abi1 scaffold protein is an essential regulator of cell movement processes required for normal eye development in Xenopus embryos and requires an Src homology 3 domain-dependent interaction with Wasp to regulate this complex morphogenetic process
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10\;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
Abelson interactor 1
, Abl-interactor protein 1 long
, abl interactor 1
, abl-binding protein 4
, eps8 SH3 domain-binding protein
, interactor protein AblBP4
, nap1 binding protein
, spectrin SH3 domain-binding protein 1
, abelson interactor 1
, eps8 binding protein
, eps8-binding protein
, spectrin SH3 domain binding protein 1
, eps8 binding protein (e3B1), alternatively spliced
, abl-interactor 1
, Abl-interactor 1
, Abl interactor 1
, abl interactor 1-like
, LOW QUALITY PROTEIN: abl interactor 1